Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on: June 15,2024

Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on:June 15,2024

Scientists discover two cellular defects appear to drive disease in lupus

byNorthwestern UniversityCredit: Pixabay/CC0 Public DomainNorthwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic im

Updated on: July 11,2024

Scientists discover two cellular defects appear to drive disease in lupus

byNorthwestern UniversityCredit: Pixabay/CC0 Public DomainNorthwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic im

Updated on:July 11,2024

Possible new biomarker for better detection of numerous inflammatory diseases

by Kiel UniversityTryptophan concentrations in the blood were significantly reduced in 9 of 13 chronic inflammatory diseases examined. Credit: S. Klahn, Exzellenzcluster PMITryptophan is an essen

Updated on: March 30,2024

Possible new biomarker for better detection of numerous inflammatory diseases

by Kiel UniversityTryptophan concentrations in the blood were significantly reduced in 9 of 13 chronic inflammatory diseases examined. Credit: S. Klahn, Exzellenzcluster PMITryptophan is an essen

Updated on:March 30,2024

Evolutionary study links subtle modifications in the morphology of the bipedal knee to osteoarthritis later in life

by Harvard UniversityA visual riff on the classic illustration, "March of Progress," highlighting the evolution of knee osteoarthritis. Credit: Tasha McAbee, Department of Orthopedics a

Updated on: May 08,2024

Evolutionary study links subtle modifications in the morphology of the bipedal knee to osteoarthritis later in life

by Harvard UniversityA visual riff on the classic illustration, "March of Progress," highlighting the evolution of knee osteoarthritis. Credit: Tasha McAbee, Department of Orthopedics a

Updated on:May 08,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on: October 10,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on:October 10,2024

Gender, high DAS28-P index predictive of pain in early RA

(HealthDay) -- For patients with rheumatoid arthritis (RA), female gender and having a high proportion of disease activity score (DAS28) attributable to patient-reported components (joint tenderness a

Updated on: April 08,2024

Gender, high DAS28-P index predictive of pain in early RA

(HealthDay) -- For patients with rheumatoid arthritis (RA), female gender and having a high proportion of disease activity score (DAS28) attributable to patient-reported components (joint tenderness a

Updated on:April 08,2024

SARS-CoV-2 curtails immune response in the gut

by European Molecular Biology LaboratoryThe researchers were able to monitor the virus's growth in organoids derived from human intestinal cells. Pink and red show areas of SARS-CoV-2 infecti

Updated on: April 22,2024

SARS-CoV-2 curtails immune response in the gut

by European Molecular Biology LaboratoryThe researchers were able to monitor the virus's growth in organoids derived from human intestinal cells. Pink and red show areas of SARS-CoV-2 infecti

Updated on:April 22,2024

With or without allergies, outcomes similar for hospitalized patients with COVID-19

byAmerican College of Allergy, Asthma, and ImmunologyDuring the COVID-19 pandemic, attention has been focused on how those with both allergies and asthma might be affected should they become ill

Updated on: March 05,2024

With or without allergies, outcomes similar for hospitalized patients with COVID-19

byAmerican College of Allergy, Asthma, and ImmunologyDuring the COVID-19 pandemic, attention has been focused on how those with both allergies and asthma might be affected should they become ill

Updated on:March 05,2024

How a plant-based diet can ease rheumatoid arthritis

by Nancy ClantonCredit: CC0 Public DomainSwitching to a plant-based diet can alleviate the pain caused by rheumatoid arthritis, a new study shows.Rheumatoid arthritis is a type of inflammatory polyart

Updated on: March 26,2024

How a plant-based diet can ease rheumatoid arthritis

by Nancy ClantonCredit: CC0 Public DomainSwitching to a plant-based diet can alleviate the pain caused by rheumatoid arthritis, a new study shows.Rheumatoid arthritis is a type of inflammatory polyart

Updated on:March 26,2024

OM85: How bacteria in a capsule could protect us from coronavirus and other respiratory infections

by Peter Sly,The ConversationCredit: AI-generated imageScientists around the world are continuing to test countless vaccines and drugs in the hope of finding effective ways to prevent and treat

Updated on: April 20,2024

OM85: How bacteria in a capsule could protect us from coronavirus and other respiratory infections

by Peter Sly,The ConversationCredit: AI-generated imageScientists around the world are continuing to test countless vaccines and drugs in the hope of finding effective ways to prevent and treat

Updated on:April 20,2024

Weekly leflunomide effective for early rheumatoid arthritis

(HealthDay)—A higher, weekly dose of leflunomide shows similar benefits to a daily dose for the treatment of mild-to-moderate early rheumatoid arthritis (ERA), according to a study published online Au

Updated on: April 08,2024

Weekly leflunomide effective for early rheumatoid arthritis

(HealthDay)—A higher, weekly dose of leflunomide shows similar benefits to a daily dose for the treatment of mild-to-moderate early rheumatoid arthritis (ERA), according to a study published online Au

Updated on:April 08,2024

Study investigates rates of adverse events for common rheumatoid arthritis drug

by Brigham and Women's HospitalCredit: CC0 Public DomainMethotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is

Updated on: June 17,2024

Study investigates rates of adverse events for common rheumatoid arthritis drug

by Brigham and Women's HospitalCredit: CC0 Public DomainMethotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is

Updated on:June 17,2024