Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis

by Johns Hopkins University School of MedicineThe proposed binding site of the PAD4-activating antibody. The PAD4 enzyme is composed of two pieces (light gray and dark gray) that are connected in

Updated on: June 06,2024

Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis

by Johns Hopkins University School of MedicineThe proposed binding site of the PAD4-activating antibody. The PAD4 enzyme is composed of two pieces (light gray and dark gray) that are connected in

Updated on:June 06,2024

How the body's immune response to bacterial infections could cause detrimental inflammation

byNanyang Technological UniversityA. Representative images of A549-ASC-GFP-NLRP1 (upper panel) or ZAKɑ KO A549-ASCGFP-NLRP1 (lower panel) reporter cells Images of GFP and DAPI fluorescence were

Updated on: March 27,2024

How the body's immune response to bacterial infections could cause detrimental inflammation

byNanyang Technological UniversityA. Representative images of A549-ASC-GFP-NLRP1 (upper panel) or ZAKɑ KO A549-ASCGFP-NLRP1 (lower panel) reporter cells Images of GFP and DAPI fluorescence were

Updated on:March 27,2024

Researchers find genetic association for interstitial lung disease

by University of TsukubaMUC5B risk allele carrier frequency in ANCA-associated vasculitis (AAV) with and without interstitial lung disease (ILD) as well as in healthy controls in the Japanese pop

Updated on: May 19,2024

Researchers find genetic association for interstitial lung disease

by University of TsukubaMUC5B risk allele carrier frequency in ANCA-associated vasculitis (AAV) with and without interstitial lung disease (ILD) as well as in healthy controls in the Japanese pop

Updated on:May 19,2024

Study reveals new role for inflammatory protein in fat tissue

byKarolinska InstitutetMicroscope image of fat cells. Credit: Kaisa HofwimmerA new studypublishedinNature Communicationsshows that the inflammatory protein IL-1β has an i

Updated on: October 30,2024

Study reveals new role for inflammatory protein in fat tissue

byKarolinska InstitutetMicroscope image of fat cells. Credit: Kaisa HofwimmerA new studypublishedinNature Communicationsshows that the inflammatory protein IL-1β has an i

Updated on:October 30,2024

Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies

by Brigham and Women's HospitalMultiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+synovial CD8 T cell (white arro

Updated on: July 03,2024

Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies

by Brigham and Women's HospitalMultiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+synovial CD8 T cell (white arro

Updated on:July 03,2024

New therapy shown to be effective in women with fibromyalgia and depression

by Universitat Oberta de CatalunyaCONSORT Diagram of participants flow in this randomized controlled trial. Credit:International Journal of Clinical and Health Psychology(2022). DOI: 10.10

Updated on: June 15,2024

New therapy shown to be effective in women with fibromyalgia and depression

by Universitat Oberta de CatalunyaCONSORT Diagram of participants flow in this randomized controlled trial. Credit:International Journal of Clinical and Health Psychology(2022). DOI: 10.10

Updated on:June 15,2024

Early combined treatment with biologic and conventional DMARDs could be effective for polyarticular juvenile arthritis

by American College of RheumatologyCredit: CC0 Public DomainNew research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, found that patients sta

Updated on: March 28,2024

Early combined treatment with biologic and conventional DMARDs could be effective for polyarticular juvenile arthritis

by American College of RheumatologyCredit: CC0 Public DomainNew research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, found that patients sta

Updated on:March 28,2024

AI model can quantify radiographic joint damage in rheumatoid arthritis

An international competition resulted in the development of algorithms that provide feasible, quick, and accurate methods to quantify joint damage in rheumatoid arthritis (RA), according to a study pu

Updated on: June 26,2024

AI model can quantify radiographic joint damage in rheumatoid arthritis

An international competition resulted in the development of algorithms that provide feasible, quick, and accurate methods to quantify joint damage in rheumatoid arthritis (RA), according to a study pu

Updated on:June 26,2024

Is metabolic syndrome a modifiable risk factor for gout?

by WileyCredit: Pixabay/CC0 Public DomainIn a study published inArthritis & Rheumatologythat included nearly 1.3 million men aged 20–39 years who participated in three serial heal

Updated on: June 01,2024

Is metabolic syndrome a modifiable risk factor for gout?

by WileyCredit: Pixabay/CC0 Public DomainIn a study published inArthritis & Rheumatologythat included nearly 1.3 million men aged 20–39 years who participated in three serial heal

Updated on:June 01,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on: October 10,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on:October 10,2024

Key type of immune cell 'self-renews' in humans, new study finds

by Cardiff UniversityCredit: CC0 Public DomainA team of scientists has shown that a key type of immune cell "self-renews" in humans.It is an unexpected discovery, as it was previously t

Updated on: April 24,2024

Key type of immune cell 'self-renews' in humans, new study finds

by Cardiff UniversityCredit: CC0 Public DomainA team of scientists has shown that a key type of immune cell "self-renews" in humans.It is an unexpected discovery, as it was previously t

Updated on:April 24,2024

Is it brain infection or cancer? A new rapid test could hold the answer

by Thomas Jefferson UniversityGram stain of meningococci from a culture showing Gram negative (pink) bacteria, often in pairs. Credit: public domainWhen patients present with neurologic symptoms

Updated on: April 16,2024

Is it brain infection or cancer? A new rapid test could hold the answer

by Thomas Jefferson UniversityGram stain of meningococci from a culture showing Gram negative (pink) bacteria, often in pairs. Credit: public domainWhen patients present with neurologic symptoms

Updated on:April 16,2024