Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on: June 15,2024

Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on:June 15,2024

Rituximab retreatment at clinical relapse cost-effective in RA

(HealthDay)—Rituximab retreatment at clinical relapse is at least as cost-effective as a more intensive regimen in longstanding rheumatoid arthritis (RA), according to a study published in the July is

Updated on: April 08,2024

Rituximab retreatment at clinical relapse cost-effective in RA

(HealthDay)—Rituximab retreatment at clinical relapse is at least as cost-effective as a more intensive regimen in longstanding rheumatoid arthritis (RA), according to a study published in the July is

Updated on:April 08,2024

A small mutation can make Zika virus even more dangerous

by La Jolla Institute for ImmunologyRepeatedly switching back and forth between mosquito cells and mice provided scientists with a window into how Zika virus naturally evolves as it encounters mo

Updated on: April 24,2024

A small mutation can make Zika virus even more dangerous

by La Jolla Institute for ImmunologyRepeatedly switching back and forth between mosquito cells and mice provided scientists with a window into how Zika virus naturally evolves as it encounters mo

Updated on:April 24,2024

Over 40 genetic links to rheumatoid arthritis discovered

by The Mount Sinai HospitalThe results of the largest international study to date into the genetic basis of rheumatoid arthritis, published in the journal Nature, shed light on the biology of the

Updated on: March 24,2024

Over 40 genetic links to rheumatoid arthritis discovered

by The Mount Sinai HospitalThe results of the largest international study to date into the genetic basis of rheumatoid arthritis, published in the journal Nature, shed light on the biology of the

Updated on:March 24,2024

Potentially predictive humoral immune response markers in COVID-19 patients

by Massachusetts General HospitalCredit: CC0 Public DomainGalit Alter, Ph.D., Group Leader at the Ragon Institute of MGH, MIT and Harvard and Professor of Medicine at Harvard Medical School, and

Updated on: April 10,2024

Potentially predictive humoral immune response markers in COVID-19 patients

by Massachusetts General HospitalCredit: CC0 Public DomainGalit Alter, Ph.D., Group Leader at the Ragon Institute of MGH, MIT and Harvard and Professor of Medicine at Harvard Medical School, and

Updated on:April 10,2024

Boosting CAR-T cell therapies from under the skin

by Benjamin Boettner,Harvard UniversityT-cell enhancing scaffolds can be locally injected under the skin following CAR-T cell therapy, and allowcirculating CAR-T cells to infiltrate their 3-dime

Updated on: June 15,2024

Boosting CAR-T cell therapies from under the skin

by Benjamin Boettner,Harvard UniversityT-cell enhancing scaffolds can be locally injected under the skin following CAR-T cell therapy, and allowcirculating CAR-T cells to infiltrate their 3-dime

Updated on:June 15,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on: October 10,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on:October 10,2024

Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies

by Brigham and Women's HospitalMultiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+synovial CD8 T cell (white arro

Updated on: July 03,2024

Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies

by Brigham and Women's HospitalMultiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+synovial CD8 T cell (white arro

Updated on:July 03,2024

X chromosome gene may explain why women are more prone to autoimmune diseases

by Alice Walton,University of California, Los Angeles(A) Using the high-throughput sequencing approach, sexually biased X chromosome genes in CD4+T cells were determined for C57BL/6J naive

Updated on: May 05,2024

X chromosome gene may explain why women are more prone to autoimmune diseases

by Alice Walton,University of California, Los Angeles(A) Using the high-throughput sequencing approach, sexually biased X chromosome genes in CD4+T cells were determined for C57BL/6J naive

Updated on:May 05,2024

Key type of immune cell 'self-renews' in humans, new study finds

by Cardiff UniversityCredit: CC0 Public DomainA team of scientists has shown that a key type of immune cell "self-renews" in humans.It is an unexpected discovery, as it was previously t

Updated on: April 24,2024

Key type of immune cell 'self-renews' in humans, new study finds

by Cardiff UniversityCredit: CC0 Public DomainA team of scientists has shown that a key type of immune cell "self-renews" in humans.It is an unexpected discovery, as it was previously t

Updated on:April 24,2024

Paradigm shift: How a risk-based program is changing health care use and outcomes for children with high-risk asthma

by Le Bonheur Children's HospitalCredit: Pixabay/CC0 Public DomainLe Bonheur Children's Hospital's risk-based innovation program Changing High-Risk Asthma in Memphis through Partnership (C

Updated on: March 07,2024

Paradigm shift: How a risk-based program is changing health care use and outcomes for children with high-risk asthma

by Le Bonheur Children's HospitalCredit: Pixabay/CC0 Public DomainLe Bonheur Children's Hospital's risk-based innovation program Changing High-Risk Asthma in Memphis through Partnership (C

Updated on:March 07,2024

New device monitors levels of inflammation-associated C-reactive protein in real time

byPolish Academy of SciencesGraphical abstract. Credit:ACS Sensors(2024). DOI: 10.1021/acssensors.4c00249As inflammation is the body's natural immune response to disease or infec

Updated on: September 02,2024

New device monitors levels of inflammation-associated C-reactive protein in real time

byPolish Academy of SciencesGraphical abstract. Credit:ACS Sensors(2024). DOI: 10.1021/acssensors.4c00249As inflammation is the body's natural immune response to disease or infec

Updated on:September 02,2024