Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on: January 11,2025

Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on:January 11,2025

Enhanced stability of tristetraprolin found to promote bone health and reduce frailty

by International Association for Dental, Oral, and Craniofacial ResearchCredit: Unsplash/CC0 Public DomainA study used a novel transgenic mouse model (TTP knock-in—TTPKI) that has a moderate elevation

Updated on: March 27,2024

Enhanced stability of tristetraprolin found to promote bone health and reduce frailty

by International Association for Dental, Oral, and Craniofacial ResearchCredit: Unsplash/CC0 Public DomainA study used a novel transgenic mouse model (TTP knock-in—TTPKI) that has a moderate elevation

Updated on:March 27,2024

Versatile antibody technology allows design of long-acting antibodies with tailored target-dependent mode of actions

by University of OsloREW enhances phagocytosis of gram-positive and killing of gram-negative bacteria. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-46321-9Antibody ther

Updated on: March 19,2024

Versatile antibody technology allows design of long-acting antibodies with tailored target-dependent mode of actions

by University of OsloREW enhances phagocytosis of gram-positive and killing of gram-negative bacteria. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-46321-9Antibody ther

Updated on:March 19,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on: May 07,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on:May 07,2024

Rheumatoid arthritis linked to peripheral artery disease

by Lori SolomonThere may be an association between rheumatoid arthritis (RA) and peripheral artery disease (PAD), according to a review published online Nov. 30 inRheumatology International.Tays

Updated on: June 26,2024

Rheumatoid arthritis linked to peripheral artery disease

by Lori SolomonThere may be an association between rheumatoid arthritis (RA) and peripheral artery disease (PAD), according to a review published online Nov. 30 inRheumatology International.Tays

Updated on:June 26,2024

Trimethoprim-induced aseptic meningitis described

(HealthDay)—Drug-induced aseptic meningitis following trimethoprim use has been described in a research letter published online Nov. 20 in theInternational Journal of Rheumatic Diseases.Gayathir

Updated on: March 24,2024

Trimethoprim-induced aseptic meningitis described

(HealthDay)—Drug-induced aseptic meningitis following trimethoprim use has been described in a research letter published online Nov. 20 in theInternational Journal of Rheumatic Diseases.Gayathir

Updated on:March 24,2024

Some severe COVID-19 cases linked to genetic mutations or antibodies that attack the body

by Howard Hughes Medical InstituteInfection with the novel coronavirus (gold spheres) can cause a range of symptoms. Some people with severe cases of COVID-19 have genetic mutations in key immuni

Updated on: May 08,2024

Some severe COVID-19 cases linked to genetic mutations or antibodies that attack the body

by Howard Hughes Medical InstituteInfection with the novel coronavirus (gold spheres) can cause a range of symptoms. Some people with severe cases of COVID-19 have genetic mutations in key immuni

Updated on:May 08,2024

How gum disease aggravates chronic obstructive pulmonary disease

by American Society for MicrobiologyCredit: CC0 Public DomainSevere gum disease has been linked to the progression of chronic obstructive pulmonary disease, or COPD, but an understanding of how t

Updated on: March 07,2024

How gum disease aggravates chronic obstructive pulmonary disease

by American Society for MicrobiologyCredit: CC0 Public DomainSevere gum disease has been linked to the progression of chronic obstructive pulmonary disease, or COPD, but an understanding of how t

Updated on:March 07,2024

Respiratory disease may increase risk for rheumatoid arthritis

(HealthDay)—Respiratory diseases increase the risk for rheumatoid arthritis, according to a study published online Aug. 16 inArthritis & Rheumatology.Vanessa L. Kronzer, M.D., from the Mayo

Updated on: July 02,2024

Respiratory disease may increase risk for rheumatoid arthritis

(HealthDay)—Respiratory diseases increase the risk for rheumatoid arthritis, according to a study published online Aug. 16 inArthritis & Rheumatology.Vanessa L. Kronzer, M.D., from the Mayo

Updated on:July 02,2024

Running, even in excess, doesn't lead to more osteoarthritis and hip replacements

by Dan Krotz,Lawrence Berkeley National LaboratoryCredit: Berkeley Lab photographer Roy Kaltschmidt(Medical Xpress)—Need another reason to dust off those running shoes in the back of the closet?

Updated on: June 06,2024

Running, even in excess, doesn't lead to more osteoarthritis and hip replacements

by Dan Krotz,Lawrence Berkeley National LaboratoryCredit: Berkeley Lab photographer Roy Kaltschmidt(Medical Xpress)—Need another reason to dust off those running shoes in the back of the closet?

Updated on:June 06,2024

A messenger substance considered to be inflammatory can alleviate asthma symptoms

by Friedrich–Alexander University Erlangen–NurnbergIntranasal rIL-3 application during challenge induces Treg cells. (A) Experimental design for lung ILC2 skewing. (B) After 5 days of in vitro IL

Updated on: May 06,2024

A messenger substance considered to be inflammatory can alleviate asthma symptoms

by Friedrich–Alexander University Erlangen–NurnbergIntranasal rIL-3 application during challenge induces Treg cells. (A) Experimental design for lung ILC2 skewing. (B) After 5 days of in vitro IL

Updated on:May 06,2024

Potential biomarkers identified for neuropsychiatric symptoms of lupus

by Laurie Fickman,University of HoustonCredit: CC0 Public DomainA globally renowned expert in autoimmune diseases and systemic lupus erythematosus (SLE) at the University of Houston has identifi

Updated on: June 06,2024

Potential biomarkers identified for neuropsychiatric symptoms of lupus

by Laurie Fickman,University of HoustonCredit: CC0 Public DomainA globally renowned expert in autoimmune diseases and systemic lupus erythematosus (SLE) at the University of Houston has identifi

Updated on:June 06,2024