Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on: January 11,2025

Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on:January 11,2025

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on: May 07,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on:May 07,2024

CAR-T therapy modifications provide new promise for cancer immunotherapies

by King's College LondonCredit: CC0 Public DomainNew research led by Dr. John Maher, from the School of Cancer & Pharmaceutical Sciences, working for Leucid Bio and with biotech company L

Updated on: April 09,2024

CAR-T therapy modifications provide new promise for cancer immunotherapies

by King's College LondonCredit: CC0 Public DomainNew research led by Dr. John Maher, from the School of Cancer & Pharmaceutical Sciences, working for Leucid Bio and with biotech company L

Updated on:April 09,2024

Rheumatoid arthritis linked to peripheral artery disease

by Lori SolomonThere may be an association between rheumatoid arthritis (RA) and peripheral artery disease (PAD), according to a review published online Nov. 30 inRheumatology International.Tays

Updated on: June 26,2024

Rheumatoid arthritis linked to peripheral artery disease

by Lori SolomonThere may be an association between rheumatoid arthritis (RA) and peripheral artery disease (PAD), according to a review published online Nov. 30 inRheumatology International.Tays

Updated on:June 26,2024

Artificial intelligence detects osteoarthritis years before it develops

by University of PittsburghCredit: CC0 Public DomainResearchers at the University of Pittsburgh School of Medicine and Carnegie Mellon University College of Engineering have created a machine-lea

Updated on: May 13,2024

Artificial intelligence detects osteoarthritis years before it develops

by University of PittsburghCredit: CC0 Public DomainResearchers at the University of Pittsburgh School of Medicine and Carnegie Mellon University College of Engineering have created a machine-lea

Updated on:May 13,2024

Some severe COVID-19 cases linked to genetic mutations or antibodies that attack the body

by Howard Hughes Medical InstituteInfection with the novel coronavirus (gold spheres) can cause a range of symptoms. Some people with severe cases of COVID-19 have genetic mutations in key immuni

Updated on: May 08,2024

Some severe COVID-19 cases linked to genetic mutations or antibodies that attack the body

by Howard Hughes Medical InstituteInfection with the novel coronavirus (gold spheres) can cause a range of symptoms. Some people with severe cases of COVID-19 have genetic mutations in key immuni

Updated on:May 08,2024

Building tolerance helps kids with wheat allergy

(HealthDay)—Giving trace amounts of wheat to children with wheat allergy shows promise in treating the allergy, according to new research.The researchers started with 46 wheat-allergicchildren,

Updated on: April 08,2024

Building tolerance helps kids with wheat allergy

(HealthDay)—Giving trace amounts of wheat to children with wheat allergy shows promise in treating the allergy, according to new research.The researchers started with 46 wheat-allergicchildren,

Updated on:April 08,2024

How gum disease aggravates chronic obstructive pulmonary disease

by American Society for MicrobiologyCredit: CC0 Public DomainSevere gum disease has been linked to the progression of chronic obstructive pulmonary disease, or COPD, but an understanding of how t

Updated on: March 07,2024

How gum disease aggravates chronic obstructive pulmonary disease

by American Society for MicrobiologyCredit: CC0 Public DomainSevere gum disease has been linked to the progression of chronic obstructive pulmonary disease, or COPD, but an understanding of how t

Updated on:March 07,2024

Respiratory disease may increase risk for rheumatoid arthritis

(HealthDay)—Respiratory diseases increase the risk for rheumatoid arthritis, according to a study published online Aug. 16 inArthritis & Rheumatology.Vanessa L. Kronzer, M.D., from the Mayo

Updated on: July 02,2024

Respiratory disease may increase risk for rheumatoid arthritis

(HealthDay)—Respiratory diseases increase the risk for rheumatoid arthritis, according to a study published online Aug. 16 inArthritis & Rheumatology.Vanessa L. Kronzer, M.D., from the Mayo

Updated on:July 02,2024

Running, even in excess, doesn't lead to more osteoarthritis and hip replacements

by Dan Krotz,Lawrence Berkeley National LaboratoryCredit: Berkeley Lab photographer Roy Kaltschmidt(Medical Xpress)—Need another reason to dust off those running shoes in the back of the closet?

Updated on: June 06,2024

Running, even in excess, doesn't lead to more osteoarthritis and hip replacements

by Dan Krotz,Lawrence Berkeley National LaboratoryCredit: Berkeley Lab photographer Roy Kaltschmidt(Medical Xpress)—Need another reason to dust off those running shoes in the back of the closet?

Updated on:June 06,2024

Potential biomarkers identified for neuropsychiatric symptoms of lupus

by Laurie Fickman,University of HoustonCredit: CC0 Public DomainA globally renowned expert in autoimmune diseases and systemic lupus erythematosus (SLE) at the University of Houston has identifi

Updated on: June 06,2024

Potential biomarkers identified for neuropsychiatric symptoms of lupus

by Laurie Fickman,University of HoustonCredit: CC0 Public DomainA globally renowned expert in autoimmune diseases and systemic lupus erythematosus (SLE) at the University of Houston has identifi

Updated on:June 06,2024

Increased use of partial knee replacement could save the NHS £30 million per year

by University of OxfordCredit: NDORMSNew research from a randomised clinical trial published today inThe Lancetand funded by the National Institute for Health Research (NIHR) shows th

Updated on: March 28,2024

Increased use of partial knee replacement could save the NHS £30 million per year

by University of OxfordCredit: NDORMSNew research from a randomised clinical trial published today inThe Lancetand funded by the National Institute for Health Research (NIHR) shows th

Updated on:March 28,2024