The secret lives of T cells: They derive energy from a master regulator that has been poorly understood, until now

by Delthia Ricks , Medical XpressIn vitro modeling of Teff STAT5 responses. (A) WT CD4+ T cells were cultured with or without blocking anti-mouse IL-2/IL-2R antibodies and/or human IL-2. Flow cytometr

Updated on: May 06,2024

The secret lives of T cells: They derive energy from a master regulator that has been poorly understood, until now

by Delthia Ricks , Medical XpressIn vitro modeling of Teff STAT5 responses. (A) WT CD4+ T cells were cultured with or without blocking anti-mouse IL-2/IL-2R antibodies and/or human IL-2. Flow cytometr

Updated on:May 06,2024

TLK protein inhibition activates the innate immune system

by Institute for Research in Biomedicine - IRBCancer cells with TLK inhibition show replication intermediates (green) at chromosome ends (red). Credit: IRB BarcelonaTousled-like kinases (TLKs) are a p

Updated on: April 24,2024

TLK protein inhibition activates the innate immune system

by Institute for Research in Biomedicine - IRBCancer cells with TLK inhibition show replication intermediates (green) at chromosome ends (red). Credit: IRB BarcelonaTousled-like kinases (TLKs) are a p

Updated on:April 24,2024

Researchers link gut microbiome to rheumatoid arthritis prognosis

by Susan Murphy,Mayo ClinicCredit: Pixabay/CC0 Public DomainA significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in thei

Updated on: June 01,2024

Researchers link gut microbiome to rheumatoid arthritis prognosis

by Susan Murphy,Mayo ClinicCredit: Pixabay/CC0 Public DomainA significant indicator of whether a patient with rheumatoid arthritis will improve over the course of disease may lie in part in thei

Updated on:June 01,2024

AD most commonly used term in literature for atopic dermatitis

(HealthDay)—Atopic dermatitis (AD) is most commonly referred to as AD in the literature, according to a review published online July 8 inAllergy.Robert Kantor, from the Northwestern University F

Updated on: April 08,2024

AD most commonly used term in literature for atopic dermatitis

(HealthDay)—Atopic dermatitis (AD) is most commonly referred to as AD in the literature, according to a review published online July 8 inAllergy.Robert Kantor, from the Northwestern University F

Updated on:April 08,2024

A better test for the tumor-targeting of CAR-T therapies

by Ludwig Institute for Cancer ResearchCredit: CC0 Public DomainLudwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-r

Updated on: April 24,2024

A better test for the tumor-targeting of CAR-T therapies

by Ludwig Institute for Cancer ResearchCredit: CC0 Public DomainLudwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-r

Updated on:April 24,2024

Examining inflammatory bowel disease after a stem cell transplant

byUniversity of BaselColon sections of the index patient in active IBDvs. clinical remission (under infliximab therapy) were stained by immune histology for CD5 (a pan T cell marker) and f

Updated on: March 27,2024

Examining inflammatory bowel disease after a stem cell transplant

byUniversity of BaselColon sections of the index patient in active IBDvs. clinical remission (under infliximab therapy) were stained by immune histology for CD5 (a pan T cell marker) and f

Updated on:March 27,2024

CAR-T therapy modifications provide new promise for cancer immunotherapies

by King's College LondonCredit: CC0 Public DomainNew research led by Dr. John Maher, from the School of Cancer & Pharmaceutical Sciences, working for Leucid Bio and with biotech company L

Updated on: April 09,2024

CAR-T therapy modifications provide new promise for cancer immunotherapies

by King's College LondonCredit: CC0 Public DomainNew research led by Dr. John Maher, from the School of Cancer & Pharmaceutical Sciences, working for Leucid Bio and with biotech company L

Updated on:April 09,2024

COVID-19: Biomarkers linked to severe forms of the disease

by University of MontrealColorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample. Image captu

Updated on: April 13,2024

COVID-19: Biomarkers linked to severe forms of the disease

by University of MontrealColorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample. Image captu

Updated on:April 13,2024

Anti-cancer virus fits tumor receptor like a 'key in a lock'

by Okinawa Institute of Science and TechnologyA cryo-EM map of the receptor decorated capsid in which a single protomer was replaced with the atomic model. Seneca Valley Virus capsid proteins are

Updated on: April 08,2024

Anti-cancer virus fits tumor receptor like a 'key in a lock'

by Okinawa Institute of Science and TechnologyA cryo-EM map of the receptor decorated capsid in which a single protomer was replaced with the atomic model. Seneca Valley Virus capsid proteins are

Updated on:April 08,2024

COVID-19, MIS-C and Kawasaki disease share same immune response

by University of California - San DiegoUC San Diego researchers summarize the similarities and differences between COVID-19, MIS-C and Kawasaki disease, three conditions unified by the same immun

Updated on: April 09,2024

COVID-19, MIS-C and Kawasaki disease share same immune response

by University of California - San DiegoUC San Diego researchers summarize the similarities and differences between COVID-19, MIS-C and Kawasaki disease, three conditions unified by the same immun

Updated on:April 09,2024

Online therapy aids the isolated, immunosuppressed in pandemic

by Noah Fromson,University of MichiganCredit: CC0 Public DomainPeople with a rare autoimmune disease, who likely experience more serious isolation during a global pandemic, saw their anxiety and

Updated on: March 24,2024

Online therapy aids the isolated, immunosuppressed in pandemic

by Noah Fromson,University of MichiganCredit: CC0 Public DomainPeople with a rare autoimmune disease, who likely experience more serious isolation during a global pandemic, saw their anxiety and

Updated on:March 24,2024

TAp63: A new protein drug target for rheumatoid arthritis

by Chiba UniversityGraphical abstract. Credit:JCI Insight(2023). DOI: 10.1172/jci.insight.164778Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The

Updated on: May 08,2024

TAp63: A new protein drug target for rheumatoid arthritis

by Chiba UniversityGraphical abstract. Credit:JCI Insight(2023). DOI: 10.1172/jci.insight.164778Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The

Updated on:May 08,2024