m6A mRNA modification potentiates Th17 functions to inflame autoimmunity

by Science China PressLoss of METTL3 in Th17 cells facilitated SOCS family RNA stability, inhibited IL-6/STAT3 mediated IL-17A and CCR5 expression, which in turn impeding Th17 cells differentiati

Updated on: April 16,2024

m6A mRNA modification potentiates Th17 functions to inflame autoimmunity

by Science China PressLoss of METTL3 in Th17 cells facilitated SOCS family RNA stability, inhibited IL-6/STAT3 mediated IL-17A and CCR5 expression, which in turn impeding Th17 cells differentiati

Updated on:April 16,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on: April 17,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on:April 17,2024

OX40-positive follicular helper T cells control rheumatoid arthritis

by University of TsukubaCredit: CC0 Public DomainRheumatoid arthritis is a progressive autoimmune disease most frequently characterized by pain, swelling, and stiffness in joints. Increased numbe

Updated on: June 17,2024

OX40-positive follicular helper T cells control rheumatoid arthritis

by University of TsukubaCredit: CC0 Public DomainRheumatoid arthritis is a progressive autoimmune disease most frequently characterized by pain, swelling, and stiffness in joints. Increased numbe

Updated on:June 17,2024

High false negative rate with PFTs in scleroderma lung disease

(HealthDay)—Use of pulmonary function tests (PFTs) is associated with high false negative rates for detection of scleroderma-associated interstitial lung disease (SSc-ILD), according to a study publis

Updated on: March 24,2024

High false negative rate with PFTs in scleroderma lung disease

(HealthDay)—Use of pulmonary function tests (PFTs) is associated with high false negative rates for detection of scleroderma-associated interstitial lung disease (SSc-ILD), according to a study publis

Updated on:March 24,2024

Scientists discover how to improve vaccine response to potentially deadly bacterium

byTrinity College DublinScanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAIDResearchers from Trinity College Dublin have taken a leap forward in understanding how we might

Updated on: July 09,2024

Scientists discover how to improve vaccine response to potentially deadly bacterium

byTrinity College DublinScanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAIDResearchers from Trinity College Dublin have taken a leap forward in understanding how we might

Updated on:July 09,2024

BAY 2927088 demonstrates 'rapid, substantial and durable responses' in patients with HER2-mutant NSCLC

BAY 2927088 demonstrates 'rapid, substantial and durable responses' in patients with HER2-mutant NSCLCby International Association for the Study of Lung CancerCredit: Unsplash/CC0 Public Domai

Updated on: September 25,2024

BAY 2927088 demonstrates 'rapid, substantial and durable responses' in patients with HER2-mutant NSCLC

BAY 2927088 demonstrates 'rapid, substantial and durable responses' in patients with HER2-mutant NSCLCby International Association for the Study of Lung CancerCredit: Unsplash/CC0 Public Domai

Updated on:September 25,2024

T cells found to require rest and maintenance

by Bill Hathaway,Yale UniversityCredit: CC0 Public DomainT cells, biology textbooks teach us, are the soldiers of the immune system, constantly on the ready to respond to a variety of threats, f

Updated on: April 24,2024

T cells found to require rest and maintenance

by Bill Hathaway,Yale UniversityCredit: CC0 Public DomainT cells, biology textbooks teach us, are the soldiers of the immune system, constantly on the ready to respond to a variety of threats, f

Updated on:April 24,2024

Novel noninvasive molecular imaging for monitoring rheumatoid arthritis

by Society of Nuclear Medicine and Molecular ImagingComparison of Tc-99m tilmanocept radiopharmaceutical uptake on planar imaging in subjects with active RA (A: 200 μg tilmanocept / 10 mCi Tc-99m; B-C

Updated on: May 08,2024

Novel noninvasive molecular imaging for monitoring rheumatoid arthritis

by Society of Nuclear Medicine and Molecular ImagingComparison of Tc-99m tilmanocept radiopharmaceutical uptake on planar imaging in subjects with active RA (A: 200 μg tilmanocept / 10 mCi Tc-99m; B-C

Updated on:May 08,2024

Study upends understanding about joint injuries

by Cornell UniversityCredit: CC0 Public DomainAn injury to the anterior cruciate ligament (ACL) can lead to severe osteoarthritis in both animal and human patients. Now, a new interdisciplinary s

Updated on: March 28,2024

Study upends understanding about joint injuries

by Cornell UniversityCredit: CC0 Public DomainAn injury to the anterior cruciate ligament (ACL) can lead to severe osteoarthritis in both animal and human patients. Now, a new interdisciplinary s

Updated on:March 28,2024

New study questions the efficacy of many osteoarthritis treatments

by Lund UniversityCredit: Pixabay/CC0 Public DomainRecruiting osteoarthritis patients with a lot of pain to clinical studies may give incorrect results if the researcher does not account for the

Updated on: May 26,2024

New study questions the efficacy of many osteoarthritis treatments

by Lund UniversityCredit: Pixabay/CC0 Public DomainRecruiting osteoarthritis patients with a lot of pain to clinical studies may give incorrect results if the researcher does not account for the

Updated on:May 26,2024

Redundancies in T cells

by Fabio Bergamin,ETH ZurichCredit: AI-generated imageResearchers at ETH Zurich have discovered redundancies in the biochemical signalling pathways of immune cells. This finding has important im

Updated on: May 05,2024

Redundancies in T cells

by Fabio Bergamin,ETH ZurichCredit: AI-generated imageResearchers at ETH Zurich have discovered redundancies in the biochemical signalling pathways of immune cells. This finding has important im

Updated on:May 05,2024

An antibody-drug combo to combat cancer

by Tokyo Medical and Dental UniversityCredit: Tokyo Medical and Dental UniversityLeukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at

Updated on: May 05,2024

An antibody-drug combo to combat cancer

by Tokyo Medical and Dental UniversityCredit: Tokyo Medical and Dental UniversityLeukemias are debilitating cancers of the hematopoietic or blood-forming cells of the bone marrow. Now, researchers at

Updated on:May 05,2024