High-dose IV vitamin C plus chemotherapy found to double survival time in advanced pancreatic cancer

by Jennifer Brown,University of IowaGraphical abstract. Credit:Redox Biology(2024). DOI: 10.1016/j.redox.2024.103375Results from a randomized, phase 2 clinical trial show that adding

Updated on: December 01,2024 0

High-dose IV vitamin C plus chemotherapy found to double survival time in advanced pancreatic cancer

by Jennifer Brown,University of IowaGraphical abstract. Credit:Redox Biology(2024). DOI: 10.1016/j.redox.2024.103375Results from a randomized, phase 2 clinical trial show that adding

Updated on:December 01,2024 0

Novel selenium carrier protein regulates ferroptosis in tumors and the brain

byTohoku UniversityPRDX6 is a critical regulator of ferroptosis surveillance. As a selenium- acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosyn

Updated on: December 01,2024 0

Novel selenium carrier protein regulates ferroptosis in tumors and the brain

byTohoku UniversityPRDX6 is a critical regulator of ferroptosis surveillance. As a selenium- acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosyn

Updated on:December 01,2024 0

Research concentrates on genes that cause tumors in the Meibomian gland

byTufts UniversityDr. Cornelia Peterson calibrates a piece of equipment used to measure intraocular pressure during an ocular toxicity study in animals. Credit: Noah MossDr. Cornelia Peterson is

Updated on: December 01,2024 0

Research concentrates on genes that cause tumors in the Meibomian gland

byTufts UniversityDr. Cornelia Peterson calibrates a piece of equipment used to measure intraocular pressure during an ocular toxicity study in animals. Credit: Noah MossDr. Cornelia Peterson is

Updated on:December 01,2024 0

Scientists create an scRNA-seq atlas of the multiple myeloma immune microenvironment across disease stages

byVIB (the Flanders Institute for Biotechnology)The MM microenvironment is characterized by the presence of T cells with an exhausted phenotype. Credit:Journal of Hematology & Oncology

Updated on: December 02,2024 0

Scientists create an scRNA-seq atlas of the multiple myeloma immune microenvironment across disease stages

byVIB (the Flanders Institute for Biotechnology)The MM microenvironment is characterized by the presence of T cells with an exhausted phenotype. Credit:Journal of Hematology & Oncology

Updated on:December 02,2024 0

All in the blood: New way to detect drug resistance in ovarian cancer patients

byWalter and Eliza Hall InstituteThe "splicing" mechanism in cancer cells allows them to repair their DNA and avoid the cell death caused by PARP inhibitor therapy, resulting in drug r

Updated on: December 02,2024 0

All in the blood: New way to detect drug resistance in ovarian cancer patients

byWalter and Eliza Hall InstituteThe "splicing" mechanism in cancer cells allows them to repair their DNA and avoid the cell death caused by PARP inhibitor therapy, resulting in drug r

Updated on:December 02,2024 0

Innovative test that detects complex DNA patterns may improve mesothelioma detection rate in blood

by Susan Murphy,Mayo ClinicStudy design. Our study involved detecting junctions that result from chromosomal rearrangements, insertions and deletions in mesothelioma in Step 1, then designing pr

Updated on: December 02,2024 0

Innovative test that detects complex DNA patterns may improve mesothelioma detection rate in blood

by Susan Murphy,Mayo ClinicStudy design. Our study involved detecting junctions that result from chromosomal rearrangements, insertions and deletions in mesothelioma in Step 1, then designing pr

Updated on:December 02,2024 0

Jumping genes for early detection of gastric cancer

by Braulio Valdebenito-MaturanaExample of a transposable element following cancer development on spatially resolved data. In green the normal epithelium, in brown the serrated lesion, and in red the t

Updated on: December 02,2024 0

Jumping genes for early detection of gastric cancer

by Braulio Valdebenito-MaturanaExample of a transposable element following cancer development on spatially resolved data. In green the normal epithelium, in brown the serrated lesion, and in red the t

Updated on:December 02,2024 0

Genetic variation enhances cancer drug sensitivity in specific patient groups, study shows

byUppsala UniversityA graphical summary illustrates the strategy used to identify CYP2D6 as a target for collateral lethality, which is driven by the widespread occurrence of loss of heterozygos

Updated on: December 01,2024 0

Genetic variation enhances cancer drug sensitivity in specific patient groups, study shows

byUppsala UniversityA graphical summary illustrates the strategy used to identify CYP2D6 as a target for collateral lethality, which is driven by the widespread occurrence of loss of heterozygos

Updated on:December 01,2024 0

Neuro-oncology experts reveal how to use AI to improve brain cancer diagnosis, monitoring and treatment

byIndiana UniversityIU School of Medicine's Spyridon Bakas said the new recommendations are a much-needed update to the current standard of care in which individual radiologists measure tumo

Updated on: December 01,2024 0

Neuro-oncology experts reveal how to use AI to improve brain cancer diagnosis, monitoring and treatment

byIndiana UniversityIU School of Medicine's Spyridon Bakas said the new recommendations are a much-needed update to the current standard of care in which individual radiologists measure tumo

Updated on:December 01,2024 0

Mobile 'Man Van' spots prostate cancer more quickly and cheaply than via GPs

byInstitute of Cancer ResearchCredit: The Man Van and The Royal Marsden NHS Foundation TrustMobile testing "Man Van" can diagnose prostate cancer in at-risk groups earlier and more aff

Updated on: December 01,2024 0

Mobile 'Man Van' spots prostate cancer more quickly and cheaply than via GPs

byInstitute of Cancer ResearchCredit: The Man Van and The Royal Marsden NHS Foundation TrustMobile testing "Man Van" can diagnose prostate cancer in at-risk groups earlier and more aff

Updated on:December 01,2024 0

Why alarm is easing over a rise in pancreatic cancer among the young

by Robin FosterExperts have been concerned by rising rates of pancreatic cancer in young adults, but new research reveals the jump in cases has not been accompanied by any increase in deaths from the

Updated on: December 02,2024 0

Why alarm is easing over a rise in pancreatic cancer among the young

by Robin FosterExperts have been concerned by rising rates of pancreatic cancer in young adults, but new research reveals the jump in cases has not been accompanied by any increase in deaths from the

Updated on:December 02,2024 0

Novel CAR T-cell therapy demonstrates efficacy and safety in preclinical models of HER2-positive solid tumors

byVall d'Hebron Institute of OncologyGeneration and characterization of p95HER2.CART cells. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-53265-7One-third of

Updated on: December 02,2024 0

Novel CAR T-cell therapy demonstrates efficacy and safety in preclinical models of HER2-positive solid tumors

byVall d'Hebron Institute of OncologyGeneration and characterization of p95HER2.CART cells. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-53265-7One-third of

Updated on:December 02,2024 0