Researchers identify protein that controls CAR T cell longevity

byChildren's Hospital of PhiladelphiaLike a lightbulb, CAR T cells designed to kill cancer often burn out due to exhaustion and poor persistence. Doan et al. discovered that a transcription

Updated on: April 28,2024

Researchers identify protein that controls CAR T cell longevity

byChildren's Hospital of PhiladelphiaLike a lightbulb, CAR T cells designed to kill cancer often burn out due to exhaustion and poor persistence. Doan et al. discovered that a transcription

Updated on:April 28,2024

Potential therapeutic target for small cell lung cancer discovered

by Melissa Rohman,Northwestern UniversityGraphic model showing how POU2AF2 establishes the poised enhancer via SWI/SNF activity-dependent recruitment of the Polycomb complex in SCLC-P subtype ce

Updated on: April 28,2024

Potential therapeutic target for small cell lung cancer discovered

by Melissa Rohman,Northwestern UniversityGraphic model showing how POU2AF2 establishes the poised enhancer via SWI/SNF activity-dependent recruitment of the Polycomb complex in SCLC-P subtype ce

Updated on:April 28,2024

Study shines light on cancer survival and a key gene mutation

by University of TorontoScientists and doctors have known about the p53 gene for a long time, and that it plays a role in halting tumour growth. Credit: Hush Naidoo via UnsplashUniversity of Toro

Updated on: July 02,2024

Study shines light on cancer survival and a key gene mutation

by University of TorontoScientists and doctors have known about the p53 gene for a long time, and that it plays a role in halting tumour growth. Credit: Hush Naidoo via UnsplashUniversity of Toro

Updated on:July 02,2024

Gut bacteria engineered to act as tumor GPS for immunotherapies

byDana-Farber Cancer InstituteBacteria displaying hDR18 enhance anti-tumor responses of MSLN-CAR NK cells. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02418-6Immunothe

Updated on: October 10,2024

Gut bacteria engineered to act as tumor GPS for immunotherapies

byDana-Farber Cancer InstituteBacteria displaying hDR18 enhance anti-tumor responses of MSLN-CAR NK cells. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02418-6Immunothe

Updated on:October 10,2024

Many breast cancer survivors may be able to forgo mammograms in old age

by Denise MannOlder breast cancer survivors often have other medical issues and a shorter life expectancy than younger breast cancer survivors. What's more, their cancers are often slow-growing, a

Updated on: January 15,2024

Many breast cancer survivors may be able to forgo mammograms in old age

by Denise MannOlder breast cancer survivors often have other medical issues and a shorter life expectancy than younger breast cancer survivors. What's more, their cancers are often slow-growing, a

Updated on:January 15,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on: March 01,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on:March 01,2024

Subtyping of breast cancer cell lines reveals insights into cancer-relevant genes

by Manuela Schüngel, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbHWaterfall plot depicting recurrent non-synonymous mutations in BC cell lines. Mutations were calle

Updated on: March 30,2024

Subtyping of breast cancer cell lines reveals insights into cancer-relevant genes

by Manuela Schüngel, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbHWaterfall plot depicting recurrent non-synonymous mutations in BC cell lines. Mutations were calle

Updated on:March 30,2024

Scientists find core regulatory circuit controlling identity of aggressive leukemia

bySt. Jude Children's Research HospitalCo-corresponding author Brian J. Abraham, PhD, and co-author Kelsey Maher, PhD. Credit: St. Jude Children's Research HospitalA collaboration betwee

Updated on: March 30,2024

Scientists find core regulatory circuit controlling identity of aggressive leukemia

bySt. Jude Children's Research HospitalCo-corresponding author Brian J. Abraham, PhD, and co-author Kelsey Maher, PhD. Credit: St. Jude Children's Research HospitalA collaboration betwee

Updated on:March 30,2024

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

by University of Chicago Medical Center5-AZA-sensitive and 5-AZA-resistant leukemia cells have distinctly different chromatin structures. Credit: Jason ChengDrug resistance is a major obstacle to

Updated on: March 09,2024

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

by University of Chicago Medical Center5-AZA-sensitive and 5-AZA-resistant leukemia cells have distinctly different chromatin structures. Credit: Jason ChengDrug resistance is a major obstacle to

Updated on:March 09,2024

Researchers make next move in the fight against ovarian cancer

by University of Arizona College of EngineeringGraphic representation of falloposcope image resolution on the University of Arizona's "Block A." Credit: University of ArizonaOvarian canc

Updated on: June 04,2024

Researchers make next move in the fight against ovarian cancer

by University of Arizona College of EngineeringGraphic representation of falloposcope image resolution on the University of Arizona's "Block A." Credit: University of ArizonaOvarian canc

Updated on:June 04,2024

Researchers characterize mechanism of action of CAR T cells

by H. Lee Moffitt Cancer Center & Research InstituteScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDThe sci

Updated on: June 08,2024

Researchers characterize mechanism of action of CAR T cells

by H. Lee Moffitt Cancer Center & Research InstituteScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDThe sci

Updated on:June 08,2024

Expert second opinion improves reliability of melanoma diagnoses

by University of California, Los AngelesCredit: CC0 Public DomainGetting a reliable diagnosis of melanoma can be a significant challenge for pathologists. The diagnosis relies on a pathologist&#3

Updated on: April 07,2024

Expert second opinion improves reliability of melanoma diagnoses

by University of California, Los AngelesCredit: CC0 Public DomainGetting a reliable diagnosis of melanoma can be a significant challenge for pathologists. The diagnosis relies on a pathologist&#3

Updated on:April 07,2024