New technique adds to the expanding suite of TAPS capabilities

byLudwig Cancer ResearchDevelopment of wglrTAPS. (A) Schematic representation of the wglrTAPS. (B) Sequence length distribution of wglrTAPS HiFi read. (C) Conversion rate of wglrTAPS at methylat

Updated on: January 13,2024

New technique adds to the expanding suite of TAPS capabilities

byLudwig Cancer ResearchDevelopment of wglrTAPS. (A) Schematic representation of the wglrTAPS. (B) Sequence length distribution of wglrTAPS HiFi read. (C) Conversion rate of wglrTAPS at methylat

Updated on:January 13,2024

Researchers identify protein that controls CAR T cell longevity

byChildren's Hospital of PhiladelphiaLike a lightbulb, CAR T cells designed to kill cancer often burn out due to exhaustion and poor persistence. Doan et al. discovered that a transcription

Updated on: April 28,2024

Researchers identify protein that controls CAR T cell longevity

byChildren's Hospital of PhiladelphiaLike a lightbulb, CAR T cells designed to kill cancer often burn out due to exhaustion and poor persistence. Doan et al. discovered that a transcription

Updated on:April 28,2024

Potential therapeutic target for small cell lung cancer discovered

by Melissa Rohman,Northwestern UniversityGraphic model showing how POU2AF2 establishes the poised enhancer via SWI/SNF activity-dependent recruitment of the Polycomb complex in SCLC-P subtype ce

Updated on: April 28,2024

Potential therapeutic target for small cell lung cancer discovered

by Melissa Rohman,Northwestern UniversityGraphic model showing how POU2AF2 establishes the poised enhancer via SWI/SNF activity-dependent recruitment of the Polycomb complex in SCLC-P subtype ce

Updated on:April 28,2024

Gut bacteria engineered to act as tumor GPS for immunotherapies

byDana-Farber Cancer InstituteBacteria displaying hDR18 enhance anti-tumor responses of MSLN-CAR NK cells. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02418-6Immunothe

Updated on: October 10,2024

Gut bacteria engineered to act as tumor GPS for immunotherapies

byDana-Farber Cancer InstituteBacteria displaying hDR18 enhance anti-tumor responses of MSLN-CAR NK cells. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02418-6Immunothe

Updated on:October 10,2024

Few with CRC in sub-Saharan Africa receive guideline-concordant care

by Elana GotkineFewer than one in 20 patients diagnosed with colorectal cancer (CRC) in Sub-Saharan Africa (SSA) receive guideline-concordant treatment, according to a study published in the September

Updated on: April 22,2024

Few with CRC in sub-Saharan Africa receive guideline-concordant care

by Elana GotkineFewer than one in 20 patients diagnosed with colorectal cancer (CRC) in Sub-Saharan Africa (SSA) receive guideline-concordant treatment, according to a study published in the September

Updated on:April 22,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on: March 01,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on:March 01,2024

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment

by Jeff Hansen,University of Alabama at BirminghamMap of redlining in Birmingham, 1933. Credit: Public domain, Wikimedia CommonsA nationwide study of 196 cities shows that housing discrimination

Updated on: March 30,2024

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment

by Jeff Hansen,University of Alabama at BirminghamMap of redlining in Birmingham, 1933. Credit: Public domain, Wikimedia CommonsA nationwide study of 196 cities shows that housing discrimination

Updated on:March 30,2024

Increasing level of alcohol intake may raise risk for cancer

Adults who increase their alcohol consumption may have a higher risk for alcohol-related cancers and all cancers versus adults who had sustained quitting or reduced levels of drinking, according to a

Updated on: February 18,2024

Increasing level of alcohol intake may raise risk for cancer

Adults who increase their alcohol consumption may have a higher risk for alcohol-related cancers and all cancers versus adults who had sustained quitting or reduced levels of drinking, according to a

Updated on:February 18,2024

Study identifies a potential therapeutic target for triple-negative breast cancer in Black patients

by Adam Pope,University of Alabama at BirminghamProtein diversity due to alternative mRNA splicing or post-translational modifications (PTMs) plays a vital role in various cellular functions. Th

Updated on: February 18,2024

Study identifies a potential therapeutic target for triple-negative breast cancer in Black patients

by Adam Pope,University of Alabama at BirminghamProtein diversity due to alternative mRNA splicing or post-translational modifications (PTMs) plays a vital role in various cellular functions. Th

Updated on:February 18,2024

'Exhausted' immune cells in healthy women could be target for breast cancer prevention

byUniversity of CambridgeImmune cell exhaustion is observed in breast tissue from carriers of BRCA1 and BRCA2 mutations long before breast cancer develops. Credit: Sara Pensa/University of Cambr

Updated on: March 30,2024

'Exhausted' immune cells in healthy women could be target for breast cancer prevention

byUniversity of CambridgeImmune cell exhaustion is observed in breast tissue from carriers of BRCA1 and BRCA2 mutations long before breast cancer develops. Credit: Sara Pensa/University of Cambr

Updated on:March 30,2024

Can physical exercise enhance the effect of chemotherapy against breast cancer?

byKarolinska InstitutetSchematic presentation of published evidence regarding physical activity and breast cancer. Credit:PLOS ONE(2022). DOI: 10.1371/journal.pone.0274804Approximate

Updated on: January 07,2024

Can physical exercise enhance the effect of chemotherapy against breast cancer?

byKarolinska InstitutetSchematic presentation of published evidence regarding physical activity and breast cancer. Credit:PLOS ONE(2022). DOI: 10.1371/journal.pone.0274804Approximate

Updated on:January 07,2024

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

by University of Chicago Medical Center5-AZA-sensitive and 5-AZA-resistant leukemia cells have distinctly different chromatin structures. Credit: Jason ChengDrug resistance is a major obstacle to

Updated on: March 09,2024

Probing RNA epigenetics and chromatin structures to predict drug resistance in leukemia

by University of Chicago Medical Center5-AZA-sensitive and 5-AZA-resistant leukemia cells have distinctly different chromatin structures. Credit: Jason ChengDrug resistance is a major obstacle to

Updated on:March 09,2024