CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on: April 09,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on:April 09,2024

Study reveals secrets of "hot" and "cold" pancreatic cancer tumors

by Perelman School of Medicine at the University of PennsylvaniaT cell high tumor. T cell high tumor. All Cell/Tumor Cells/T Cells. Credit: Perelman School of Medicine at the University of Pennsy

Updated on: July 02,2024

Study reveals secrets of "hot" and "cold" pancreatic cancer tumors

by Perelman School of Medicine at the University of PennsylvaniaT cell high tumor. T cell high tumor. All Cell/Tumor Cells/T Cells. Credit: Perelman School of Medicine at the University of Pennsy

Updated on:July 02,2024

Newly discovered mechanism helps tumor cells evade the immune system early on

byTechnical University MunichDr. Jan Böttcher, group leader and TUM Junior Fellow at the Institute of Molecular Immunology at Klinikum rechts der Isar (left) and doctoral student Sebastian Lache

Updated on: April 28,2024

Newly discovered mechanism helps tumor cells evade the immune system early on

byTechnical University MunichDr. Jan Böttcher, group leader and TUM Junior Fellow at the Institute of Molecular Immunology at Klinikum rechts der Isar (left) and doctoral student Sebastian Lache

Updated on:April 28,2024

How conquering a rare leukemia in children revolutionized cancer care for millions

by Marie McculloughFifty years ago, children with an aggressive form of leukemia went from diagnosis to death in a few months, as the disease rampaged through their lymph nodes, spleens, livers, and n

Updated on: March 01,2024

How conquering a rare leukemia in children revolutionized cancer care for millions

by Marie McculloughFifty years ago, children with an aggressive form of leukemia went from diagnosis to death in a few months, as the disease rampaged through their lymph nodes, spleens, livers, and n

Updated on:March 01,2024

Adding metastasis-directed radiation therapy boosts progression-free survival in metastatic pancreatic cancer

byUniversity of Texas M. D. Anderson Cancer CenterCredit: Unsplash/CC0 Public DomainResearchers from The University of Texas MD Anderson Cancer Center have demonstrated that adding metastasis-di

Updated on: August 28,2024

Adding metastasis-directed radiation therapy boosts progression-free survival in metastatic pancreatic cancer

byUniversity of Texas M. D. Anderson Cancer CenterCredit: Unsplash/CC0 Public DomainResearchers from The University of Texas MD Anderson Cancer Center have demonstrated that adding metastasis-di

Updated on:August 28,2024

Team pioneers cancer treatment that targets bone metastases while sparing bone

by University of California, IrvineCredit: CC0 Public DomainUniversity of California, Irvine researchers have developed and tested on mice a therapeutic treatment that uses engineered stem cells

Updated on: May 27,2024

Team pioneers cancer treatment that targets bone metastases while sparing bone

by University of California, IrvineCredit: CC0 Public DomainUniversity of California, Irvine researchers have developed and tested on mice a therapeutic treatment that uses engineered stem cells

Updated on:May 27,2024

Double trouble for triple-negative breast cancer: Two-pronged strategy restores immunotherapy sensitivity

by Kimberly McGhee,Medical University of South CarolinaTumor-fighting immune cells in the tumor before (left) and after (right) combination therapy. After combination therapy, many more tumor-fi

Updated on: September 27,2024

Double trouble for triple-negative breast cancer: Two-pronged strategy restores immunotherapy sensitivity

by Kimberly McGhee,Medical University of South CarolinaTumor-fighting immune cells in the tumor before (left) and after (right) combination therapy. After combination therapy, many more tumor-fi

Updated on:September 27,2024

Moderate exercise helps colorectal cancer patients live longer by reducing inflammation and improving gut bacteria

by Heather Simonsen,University of UtahCredit: Pixabay/CC0 Public DomainRegular physical activity can extend colorectal cancer patients' lives. In a first-ever study, scientists looked at the

Updated on: January 04,2024

Moderate exercise helps colorectal cancer patients live longer by reducing inflammation and improving gut bacteria

by Heather Simonsen,University of UtahCredit: Pixabay/CC0 Public DomainRegular physical activity can extend colorectal cancer patients' lives. In a first-ever study, scientists looked at the

Updated on:January 04,2024

Team introduces new approach in cancer therapy with innovative mechanism-of-action for ferroptosis induction

byHelmholtz Zentrum MünchenFSP1 condensates in green induced by icFSP1 surrounding a blue nucleus. Credit: Toshitaka NakamuraA team of researchers led by Dr. Marcus Conrad from Helmholtz Munich

Updated on: January 08,2024

Team introduces new approach in cancer therapy with innovative mechanism-of-action for ferroptosis induction

byHelmholtz Zentrum MünchenFSP1 condensates in green induced by icFSP1 surrounding a blue nucleus. Credit: Toshitaka NakamuraA team of researchers led by Dr. Marcus Conrad from Helmholtz Munich

Updated on:January 08,2024

Tumor cells' response to chemotherapy is driven by randomness, shows study

byGarvan Institute of Medical ResearchNeuroblastoma cells (cyan) growing as a tumour and the surrounding collagen matrix (magenta). The cells are expressing a biosensor (JNK-KTR) that reads out

Updated on: January 23,2024

Tumor cells' response to chemotherapy is driven by randomness, shows study

byGarvan Institute of Medical ResearchNeuroblastoma cells (cyan) growing as a tumour and the surrounding collagen matrix (magenta). The cells are expressing a biosensor (JNK-KTR) that reads out

Updated on:January 23,2024

Researchers develop scalable synthesis of cancer-fighting compounds

byH. Lee Moffitt Cancer Center & Research InstituteCredit:Science Advances(2024). DOI: 10.1126/sciadv.adp9375Withanolides, a class of naturally occurring compounds found in plant

Updated on: July 08,2024

Researchers develop scalable synthesis of cancer-fighting compounds

byH. Lee Moffitt Cancer Center & Research InstituteCredit:Science Advances(2024). DOI: 10.1126/sciadv.adp9375Withanolides, a class of naturally occurring compounds found in plant

Updated on:July 08,2024

New computer platform helps match patients with cancer to trials of targeted therapy

byDana-Farber Cancer InstituteMatchMiner overview of data flow and modes of use. a) Data inputs from patients and trials are utilized by the MatchEngine to match patients to trials. b) Shown are

Updated on: January 12,2024

New computer platform helps match patients with cancer to trials of targeted therapy

byDana-Farber Cancer InstituteMatchMiner overview of data flow and modes of use. a) Data inputs from patients and trials are utilized by the MatchEngine to match patients to trials. b) Shown are

Updated on:January 12,2024