Tackling resistance to HIF2 drugs with an RNA-based therapy

byUT Southwestern Medical CenterDownregulation of HIF2α by ARO-HIF2 in patient tumor biopsies. Credit: Dr. Payal KapurExpected to be diagnosed in 2% of men and 1% of women in the U.S., kidney ca

Updated on: December 28,2023

Tackling resistance to HIF2 drugs with an RNA-based therapy

byUT Southwestern Medical CenterDownregulation of HIF2α by ARO-HIF2 in patient tumor biopsies. Credit: Dr. Payal KapurExpected to be diagnosed in 2% of men and 1% of women in the U.S., kidney ca

Updated on:December 28,2023

Interpreting and Commenting on the Role of Oct4 in M2 Macrophage Polarization and Tumor Progression in Lung Cancer

Updated on: October 01,2024

Interpreting and Commenting on the Role of Oct4 in M2 Macrophage Polarization and Tumor Progression in Lung Cancer

Updated on:October 01,2024

How oxygen deprivation causes cancer cells to spread

byLeiden UniversityCredit: Pixabay/CC0 Public DomainIn breast cancer, metastasis rather than the primary tumor is the cause of death. A lack of oxygen in the tumor cells promotes this metastasis

Updated on: January 02,2024

How oxygen deprivation causes cancer cells to spread

byLeiden UniversityCredit: Pixabay/CC0 Public DomainIn breast cancer, metastasis rather than the primary tumor is the cause of death. A lack of oxygen in the tumor cells promotes this metastasis

Updated on:January 02,2024

Enlarged genotype-phenotype correlation for a three-base pair deletion in neurofibromatosis type 1

by Jeff Hansen,University of Alabama at BirminghamLudwine Messiaen, Ph.D., left, and Magdalena Koczkowska, Ph.D. Credit: University of Alabama at BirminghamInternational collaborative research l

Updated on: March 14,2024

Enlarged genotype-phenotype correlation for a three-base pair deletion in neurofibromatosis type 1

by Jeff Hansen,University of Alabama at BirminghamLudwine Messiaen, Ph.D., left, and Magdalena Koczkowska, Ph.D. Credit: University of Alabama at BirminghamInternational collaborative research l

Updated on:March 14,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on: April 09,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on:April 09,2024

Many breast cancer survivors do not receive genetic testing, despite being eligible

by Nicole Fawcett,University of MichiganCredit: Unsplash/CC0 Public DomainAs cancer treatment and survivorship care relies more on understanding the genetic make-up of an individual's tumor,

Updated on: July 17,2024

Many breast cancer survivors do not receive genetic testing, despite being eligible

by Nicole Fawcett,University of MichiganCredit: Unsplash/CC0 Public DomainAs cancer treatment and survivorship care relies more on understanding the genetic make-up of an individual's tumor,

Updated on:July 17,2024

Wide variation in bowel cancer rates after colonoscopies in England

by British Medical JournalBowel cancer survivor John Barnes. Credit: University of LeedsSubstantial variation exists between colonoscopy providers in rates of bowel cancer up to three years after

Updated on: May 11,2024

Wide variation in bowel cancer rates after colonoscopies in England

by British Medical JournalBowel cancer survivor John Barnes. Credit: University of LeedsSubstantial variation exists between colonoscopy providers in rates of bowel cancer up to three years after

Updated on:May 11,2024

Subtypes of fibroblasts associated with skin cancer could lead to novel immunotherapies

byMedical University of ViennaSchematic summary of spatial distribution of distinct CAF subsets in human skin cancer. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-5390

Updated on: December 01,2024

Subtypes of fibroblasts associated with skin cancer could lead to novel immunotherapies

byMedical University of ViennaSchematic summary of spatial distribution of distinct CAF subsets in human skin cancer. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-5390

Updated on:December 01,2024

Trial shows improvements in several clinical outcomes for men with intermediate-risk prostate cancer

by NRG OncologyCredit: Unsplash/CC0 Public DomainResults from the phase 3 NRG Oncology RTOG 0815 clinical study comparing dose-escalated radiotherapy (RT) alone to dose-escalated RT with short-term an

Updated on: January 04,2024

Trial shows improvements in several clinical outcomes for men with intermediate-risk prostate cancer

by NRG OncologyCredit: Unsplash/CC0 Public DomainResults from the phase 3 NRG Oncology RTOG 0815 clinical study comparing dose-escalated radiotherapy (RT) alone to dose-escalated RT with short-term an

Updated on:January 04,2024

Research perspective: Cancer prevention with rapamycin

by Impact Journals LLCRapamycin prevents cancer by slowing tumor progression (hypothetical schema). (A) Rapamycin slows tumor progression and delays cancer and death from cancer. (B) Rapamycin slows t

Updated on: January 30,2024

Research perspective: Cancer prevention with rapamycin

by Impact Journals LLCRapamycin prevents cancer by slowing tumor progression (hypothetical schema). (A) Rapamycin slows tumor progression and delays cancer and death from cancer. (B) Rapamycin slows t

Updated on:January 30,2024

Novel late-stage colorectal cancer treatment proves effective in preclinical models

by Angel Mendez,University of Minnesota Medical SchoolThe low T cells are due to exosomal, immunosuppressive miRNAs that disrupt T cell function and loss of T cells in the tumor environment. Cre

Updated on: April 29,2024

Novel late-stage colorectal cancer treatment proves effective in preclinical models

by Angel Mendez,University of Minnesota Medical SchoolThe low T cells are due to exosomal, immunosuppressive miRNAs that disrupt T cell function and loss of T cells in the tumor environment. Cre

Updated on:April 29,2024

Possible therapeutic approach to fight incurable blood cancer

by Technical University MunichGraphical abstract. Credit:The EMBO Journal(2022). DOI: 10.15252/embj.2022110871Multiple myeloma (MM) is the second most common type of blood cancer. It

Updated on: January 30,2024

Possible therapeutic approach to fight incurable blood cancer

by Technical University MunichGraphical abstract. Credit:The EMBO Journal(2022). DOI: 10.15252/embj.2022110871Multiple myeloma (MM) is the second most common type of blood cancer. It

Updated on:January 30,2024