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Rapamycin prevents cancer by slowing tumor progression (hypothetical schema). (A) Rapamycin slows tumor progression and delays cancer and death from cancer. (B) Rapamycin slows tumor progression and delays cancer. A person dies from another cause (e.g., cardiovascular disease, CVD) before cancer developed. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28410

A new research perspective was published in Oncotarget entitled "Cancer prevention with rapamycin."

The mTOR (Target of Rapamycin) pathway is involved in both cancer and aging. Furthermore, common cancers are age-related diseases, and their incidence increases exponentially with age. In his new research perspective, Mikhail V. Blagosklonny, M.D., Ph.D., from Roswell Park Comprehensive Cancer Center discusses rapamycin and other rapalogs and their potential to delay cancer by targeting pre-cancerous cells and slowing down organismal aging.

"Rapamycin (sirolimus) and other rapalogs (everolimus) are anti-cancer and anti-aging drugs, which delay cancer by directly targeting pre-cancerous cells and, indirectly, by slowing down organism aging," state the researchers.

Cancer is an age-related disease and, figuratively, by slowing down time (and aging), rapamycin may delay cancer. In several dozen murine models, rapamycin robustly and reproducibly prevents cancer. Rapamycin slows cell proliferation and tumor progression, thus delaying the onset of cancer in carcinogen-treated, genetically cancer-prone and normal mice.

Credit: Impact Journals LLC

Data on the use of rapamycin and everolimus in organ-transplant patients are consistent with their cancer-preventive effects. Treatment with rapamycin was proposed to prevent lung cancer in smokers and former smokers. Clinical trials in high-risk populations are warranted.

"Currently, an increasing number of healthy people use rapamycin off-label to slow down aging. Perhaps in ten or twenty years from now, data will accumulate for retrospective analysis of cancer-prevention with rapamycin in humans," conclude the researchers.

More information: Mikhail V. Blagosklonny, Cancer prevention with rapamycin, Oncotarget (2023). DOI: 10.18632/oncotarget.28410

Journal information: Oncotarget 

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