Joint Symptoms Combined With Gastrointestinal Problems

By Carol Eustice 

 Medically reviewed by David Ozeri, MD

Enteropathic arthritis is an inflammatory condition affecting the spine and other joints that commonly occurs in the inflammatory bowel diseases – Crohn's disease and ulcerative colitis. Inflammatory arthritis associated with other enteropathic diseases, such as like celiac disease and Whipple's disease, are not generally included in "enteropathic arthritis."1

Enteropathic arthritis is classified as one of the spondyloarthropathies. Other spondyloarthropathies include ankylosing spondylitis, psoriatic arthritis, and reactive arthritis. "Enteropathy" refers to any disease related to the intestines.

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Paul Bradbury/OJO Images/Getty

Symptoms

Enteropathic arthritis may occur as axial arthritis, peripheral arthritis, or mixed. As axial arthritis, symptoms of back pain and stiffness resemble ankylosing spondylitis and may precede gastrointestinal symptoms. As peripheral arthritis, there is typically a pattern of pauciarticular (four or fewer joints involved) and asymmetric arthritis (affected joints are not on the same side of the body). The gastrointestinal problems can occur at the same time as arthritis or arthritis can occur before bowel disease.

Causes

In enteropathic arthritis, the arthritis symptoms can precede the gastrointestinal symptoms for a long period of time.

Until the gastrointestinal symptoms are apparent, the arthritis is often classified as Undifferentiated Spondyloarthritis. Most people with enteropathic arthritis, however, have already been diagnosed with one of the inflammatory bowel diseases.

Study results published in Clinical Rheumatology suggested that IL-23, a biomarker, is higher in people with inflammatory bowel disease, especially Crohn's disease, and it is higher in those with peripheral and/or axial arthritis compared to controls. More studies are needed, but it may be a significant finding that could lead to a new therapeutic target.2

Diagnosis

An open and honest discussion with your healthcare provider about all of your symptoms is the place to start. Typically healthcare providers do tests to look for:

  • Anemia

  • Elevated CRP and ESR indicative of inflammation

  • Characteristic changes on an X-ray of peripheral joints

  • Sacroiliac and spine X-rays that resemble ankylosing spondylitis

One study, published in Autoimmunity Reviews, assessed the performance of a Gastrointestinal and Rheumatologic Clinic. The study revealed that people with spondylitis had a higher prevalence of other autoimmune extra-intestinal manifestations and received more treatment with TNF blockers than people with inflammatory bowel disease.3

Those who had symptom onset of enteropathic spondylitis in the decade between 1980 to 1990 and 1991 to 2001 experienced a significant delay in diagnosis. It has improved considerably.

People who had disease onset of enteropathic spondylitis between 2002 to 2012 had reduced delay in diagnosis. It seems evident that clinics with a multidisciplinary approach, focusing on both the joint symptoms and gastrointestinal symptoms, is optimal for this particular diagnosis.

Treatment

Enteropathic arthritis is treated much the same as other spondyloarthropathies for joint symptoms. The problem is that both conditions must be dealt with—the arthritis as well as the bowel disease—but as NSAIDs may effectively treat arthritis, the drugs may make bowel disease worse.

TNF inhibitors, which include Remicade (infliximab), Humira (adalimumab) and Cimzia (certolizumab pegol) have been successfully used to treat inflammatory bowel disease. They are also effective for inflammatory arthritis.

Sources

Overview of Enteropathic Arthritis/Arthritis Associated With Inflammatory Bowel Disease. Spondylitis Association of America.

Gheita, TA. Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: preliminary results. Clinical Rheumatology. 2014 May;33(5):713-7. doi:10.1007/s10067-013-2469-y

Conigliaro P., et al. Impact of a multidisciplinary approach in enteropathic spondyloarthritis patients. Autoimmunity Reviews. 2016 Feb;15(2):184-90. doi:10.1016/j.autrev.2015.11.002

Additional Reading

Enteropathic Spondyloarthritis. Primer on the Rheumatic Diseases. Thirteenth edition. Published by Arthritis Foundation. doi:10.1007/978-0-387-68566-3


By Carol Eustice
Carol Eustice is a writer covering arthritis and chronic illness, who herself has been diagnosed with both rheumatoid arthritis and osteoarthritis.