by Queen Mary, University of London

Credit: CC0 Public Domain

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London.

The researchers show for the first time how mechanical forces experienced by cells in joints during exercise prevent cartilage degradation by suppressing the action of inflammatory molecules which cause osteoarthritis.

The study, published in the journal Osteoarthritis and Cartilage, demonstrates the benefits of exercise on the tissues that form our joints and how this is down to tiny hair-like structures called primary cilia found on living cells.

During exercise the cartilage in joints such as the hip and knee is squashed. This mechanical distortion is detected by the living cells in the cartilage which then block the action of inflammatory molecules associated with conditions such as arthritis.

The researchers show that this anti-inflammatory effect of physical activity is caused by activation of a particular protein, called HDAC6, which triggers changes in the proteins that form primary cilia.

Pharmaceutical drugs that blocked HDAC6 activation prevented the anti-inflammatory effects of physical activity, whilst other drug treatments were able to mimic the benefits of exercise.

Changes in length of the primary cilia, which are only a few 1000th of a millimetre, provided a biomarker of the level of inflammation. Cilia got longer during inflammation, but treatments that prevented this elongation successfully prevented inflammation.

Mr Su Fu, Ph.D. student at Queen Mary University of London and study author, said: "We have known for some time that healthy exercise is good for you—now we know the process through which exercise prevents cartilage degradation."

Professor Martin Knight, lead researcher of the study added: "These findings may also explain the anti-inflammatory effects of normal blood flow in arteries which is important for preventing arterial disease such as atherosclerosis and aneurism."

The researchers hope that these findings will help in the search for treatments for arthritis which affects over three million people in the UK causing stiff and painful joints.

The researchers suggest the results may lead to a whole new therapeutic approach known as mechano-medicine in which drugs simulate the effect of mechanical forces to prevent the damaging effects of inflammation and treat conditions such as arthritis.

More information: Su Fu (MD) et al, Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation, Osteoarthritis and Cartilage (2019). DOI: 10.1016/j.joca.2019.03.003

Provided by Queen Mary, University of London