by King's College London

Child offspring cardiovascular health benefits of preconception and antenatal lifestyle interventions in women with obesity. The impact of maternal obesity on child cardiovascular remodeling (A) and the protective effect of preconception and antenatal lifestyle interventions (B). Figure created with BioRender.com. Credit: International Journal of Obesity (2024). DOI: 10.1038/s41366-024-01536-0

Researchers from King's have identified evidence to suggest that lifestyle changes could offset the risk of some adult heart disorders that result from maternal obesity and changes in fetal heart development.

Obesity rates during pregnancy are increasing globally, with more than 50% of women who attend antenatal clinics in England and Wales being classified as having overweight (28.5%) or obesity (22.7%). Recent reviews have shown that maternal obesity can lead to complications for cardiovascular health and abnormal heart development in children.

In an article recently published in the International Journal of Obesity, researchers led by Dr. Samuel Burden undertook a systematic review of the existing data from studies that have investigated whether lifestyle interventions in maternal obesity, either before or during pregnancy, result in healthier hearts in children.

The team identified studies based on pre-determined criteria and included randomized trials of lifestyle interventions in pregnant women with obesity, such as antenatal exercise, diet, and physical activity.

The studies examined suggest that lifestyle interventions in women with obesity could prevent abnormal heart 'development' in children. This includes benefits which are all typically associated with better heart health such as reduced thickening of the heart walls, normal heart weight and less risk of elevated heart rates.

"We and others have shown that maternal obesity is linked with markers of unhealthy heart development in children.

"We reviewed the existing literature on whether diet and exercise interventions in women with obesity either before or during pregnancy can reduce the impact of this and found evidence that these interventions indeed protect against the degree of unhealthy heart development in their children.

"If these findings persist until adulthood, then these interventions could incur protection against the adverse cardiovascular outcomes experienced by adult offspring of women with obesity and inform public health strategies to improve the cardiovascular health of the next generation," says Dr. Samuel Burden, Research Associate, Department of Women & Children's Health.

Although there is evidence to suggest that lifestyle interventions in women with obesity may protect against cardiovascular risk in infants, further longitudinal studies with larger sample sizes and in older children are required to confirm these observations and to determine whether these changes persist to adulthood.

If confirmed in future studies, then the authors suggest that these findings will help to inform public health strategies to improve the cardiovascular health of the next generation.

More information: Samuel J. Burden et al, Maternal obesity and offspring cardiovascular remodelling — the effect of preconception and antenatal lifestyle interventions: a systematic review, International Journal of Obesity (2024). DOI: 10.1038/s41366-024-01536-0

Journal information: International Journal of Obesity 

Provided by King's College London