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New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

byThe Mount Sinai HospitalKiNet functionalities. Credit:npj Systems Biology and Applications(2024). DOI: 10.1038/s41540-024-00442-5Researchers from the Icahn School of Medicine at Mo

New web portal empowers drug discovery, systems-level analysis of critical kinase-substrate interactions

byThe Mount Sinai HospitalKiNet functionalities. Credit:npj Systems Biology and Applications(2024). DOI: 10.1038/s41540-024-00442-5Researchers from the Icahn School of Medicine at Mo
FDA Approves Lymphir: A New Hope for CTCL Patients

FDA Approves Lymphir: A New Hope for CTCL Patients

The U.S. Food and Drug Administration (FDA) had approved Lymphir (denileukin diftitox-cxdl), a novel immunotherapy for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.

FDA Approves Lymphir: A New Hope for CTCL Patients

The U.S. Food and Drug Administration (FDA) had approved Lymphir (denileukin diftitox-cxdl), a novel immunotherapy for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.
Better cancer trials could be around the corner

Better cancer trials could be around the corner

by Cold Spring Harbor LaboratoryCredit: Pixabay/CC0 Public DomainCold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led aCOVID-19 clinical trial&nbsp

Better cancer trials could be around the corner

by Cold Spring Harbor LaboratoryCredit: Pixabay/CC0 Public DomainCold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led aCOVID-19 clinical trial&nbsp
Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups

Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups

by Zara Abrams,Keck School of Medicine of USCCredit: CC0 Public DomainSmoking changes the way genes are expressed, which later contributes to the development of lung cancer and other smoking-rel

Large-scale study explores link between smoking and DNA changes across six racial and ethnic groups

by Zara Abrams,Keck School of Medicine of USCCredit: CC0 Public DomainSmoking changes the way genes are expressed, which later contributes to the development of lung cancer and other smoking-rel
Researchers define new subtypes of common brain disorder

Researchers define new subtypes of common brain disorder

by Mark Reynolds,Washington University School of MedicineAn MRI scan shows a Chiari type-1 malformation, in which the cerebellum extends beyond the gap in the skull where it connects to the spin

Researchers define new subtypes of common brain disorder

by Mark Reynolds,Washington University School of MedicineAn MRI scan shows a Chiari type-1 malformation, in which the cerebellum extends beyond the gap in the skull where it connects to the spin
Bridging diet, microbes, and metabolism: Implications for metabolic disorders

Bridging diet, microbes, and metabolism: Implications for metabolic disorders

FEBRUARY 20, 2024byBoyce Thompson InstituteTransgenic animals expressing a green fluorescent protein attached to the fatty acid desaturase, FAT-7. Green color represents the induction of FAT-7 i

Bridging diet, microbes, and metabolism: Implications for metabolic disorders

FEBRUARY 20, 2024byBoyce Thompson InstituteTransgenic animals expressing a green fluorescent protein attached to the fatty acid desaturase, FAT-7. Green color represents the induction of FAT-7 i
Scientists discover a potential way to repair synapses damaged in Alzheimer's disease

Scientists discover a potential way to repair synapses damaged in Alzheimer's disease

FEBRUARY 1, 2024by Buck Institute for Research on AgingThe art depicts the recovery of the functional plasticity at synapses on neurons despite tau-induced toxicity in the brain. Credit: Larissa Brown

Scientists discover a potential way to repair synapses damaged in Alzheimer's disease

FEBRUARY 1, 2024by Buck Institute for Research on AgingThe art depicts the recovery of the functional plasticity at synapses on neurons despite tau-induced toxicity in the brain. Credit: Larissa Brown
'It's the greatest living experiment': Pitt Men's Study marks 40 years of AIDS research

'It's the greatest living experiment': Pitt Men's Study marks 40 years of AIDS research

by Anya Sostek, Pittsburgh Post-GazetteCredit: Pixabay/CC0 Public DomainIn a Pittsburgh hospital in the early 1980s, Charles Rinaldo saw a young, previously healthy gay man critically ill with a virus

'It's the greatest living experiment': Pitt Men's Study marks 40 years of AIDS research

by Anya Sostek, Pittsburgh Post-GazetteCredit: Pixabay/CC0 Public DomainIn a Pittsburgh hospital in the early 1980s, Charles Rinaldo saw a young, previously healthy gay man critically ill with a virus
Researchers describe tools to better understand CaMKII, a protein involved in brain and heart disease

Researchers describe tools to better understand CaMKII, a protein involved in brain and heart disease

by CU Anschutz Medical CampusOptogenetic tools for monitoring and controlling CaMKII activation(A) Camui is a FRET-based sensor that detects conformational changes in CaMKII upon activation. An N

Researchers describe tools to better understand CaMKII, a protein involved in brain and heart disease

by CU Anschutz Medical CampusOptogenetic tools for monitoring and controlling CaMKII activation(A) Camui is a FRET-based sensor that detects conformational changes in CaMKII upon activation. An N
New study finds systematic biases at play in clinical trials

New study finds systematic biases at play in clinical trials

byMichigan State UniversityCredit: Pixabay/CC0 Public DomainRandomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical

New study finds systematic biases at play in clinical trials

byMichigan State UniversityCredit: Pixabay/CC0 Public DomainRandomized controlled trials, or RCTs, are believed to be the best way to study the safety and efficacy of new treatments in clinical