Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on: March 14,2024 16

Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on:March 14,2024 16

Study with over 11,000 individuals of African descent finds genetic variants linked to glaucoma

byCell PressDiscovery of known and previously undescribed loci from the discovery mega-analysis of African ancestry individuals. Credit: Cell/Verma et al.Glaucoma is the leading cause of irrever

Updated on: March 14,2024 12

Study with over 11,000 individuals of African descent finds genetic variants linked to glaucoma

byCell PressDiscovery of known and previously undescribed loci from the discovery mega-analysis of African ancestry individuals. Credit: Cell/Verma et al.Glaucoma is the leading cause of irrever

Updated on:March 14,2024 12

New insights on kidney disease in African Americans could lead to therapies

by Sarah Avery,Duke UniversityCredit:Journal of Clinical Investigation(2024). DOI: 10.1172/JCI172262In a finding that could help reduce the racial disparity in kidney disease, Duke H

Updated on: March 14,2024 3

New insights on kidney disease in African Americans could lead to therapies

by Sarah Avery,Duke UniversityCredit:Journal of Clinical Investigation(2024). DOI: 10.1172/JCI172262In a finding that could help reduce the racial disparity in kidney disease, Duke H

Updated on:March 14,2024 3

New insight into gene uncovers its link to incurable birth defect

byWalter and Eliza Hall Institute of Medical Researchimage shows neurons and their connections to each other in red and yellow, and the cell's DNA in blue. WEHI researchers have, for the fir

Updated on: March 14,2024 5

New insight into gene uncovers its link to incurable birth defect

byWalter and Eliza Hall Institute of Medical Researchimage shows neurons and their connections to each other in red and yellow, and the cell's DNA in blue. WEHI researchers have, for the fir

Updated on:March 14,2024 5

Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development

by Mario Aguilera,University of California - San DiegoChanging the instructions for development: Single-letter changes to genomes led to the formation of an extra digit (right). Credit: Fabian L

Updated on: March 14,2024 5

Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development

by Mario Aguilera,University of California - San DiegoChanging the instructions for development: Single-letter changes to genomes led to the formation of an extra digit (right). Credit: Fabian L

Updated on:March 14,2024 5

COPD and the effect of low-dose cadmium, a highly toxic metal, on airway epithelial cells

FEBRUARY 2, 2024 Editors' notesby Jeff Hansen,University of Alabama at BirminghamCredit: Pixabay/CC0 Public DomainCigarette smoke exposure is associated with the development and severity of

Updated on: March 14,2024 12

COPD and the effect of low-dose cadmium, a highly toxic metal, on airway epithelial cells

FEBRUARY 2, 2024 Editors' notesby Jeff Hansen,University of Alabama at BirminghamCredit: Pixabay/CC0 Public DomainCigarette smoke exposure is associated with the development and severity of

Updated on:March 14,2024 12

CRISPR and other new technologies open doors for drug development, but which diseases get prioritized?

DECEMBER 14, 2023 Editors' notesby C. Michael White,The ConversationCredit: Pixabay/CC0 Public DomainPrescription drugs and vaccines revolutionized health care, dramatically decreasing death

Updated on: March 14,2024 22

CRISPR and other new technologies open doors for drug development, but which diseases get prioritized?

DECEMBER 14, 2023 Editors' notesby C. Michael White,The ConversationCredit: Pixabay/CC0 Public DomainPrescription drugs and vaccines revolutionized health care, dramatically decreasing death

Updated on:March 14,2024 22

How does HIV get into the cell's center to kickstart infection?

JANUARY 24, 2024 Editors' notesbyUniversity of New South WalesIntact HIV-1 CLPs penetrate Nup98 condensates via FG-binding pocket. Credit:Nature(2024). DOI: 10.1038/s41586-023-06

Updated on: March 14,2024 11

How does HIV get into the cell's center to kickstart infection?

JANUARY 24, 2024 Editors' notesbyUniversity of New South WalesIntact HIV-1 CLPs penetrate Nup98 condensates via FG-binding pocket. Credit:Nature(2024). DOI: 10.1038/s41586-023-06

Updated on:March 14,2024 11

HIV: Early treatment is one key to remission

JANUARY 23, 2024 Editors' notesbyPasteur InstituteThe anti-SIV antibody levels after treatment interruption are associated with the magnitude of antigen stimulation. Kinetics of plasma anti-

Updated on: March 14,2024 11

HIV: Early treatment is one key to remission

JANUARY 23, 2024 Editors' notesbyPasteur InstituteThe anti-SIV antibody levels after treatment interruption are associated with the magnitude of antigen stimulation. Kinetics of plasma anti-

Updated on:March 14,2024 11

Netflix's 'You Are What You Eat' uses a twin study. Why studying twins is so important for science

by Nathan Kettlewell,The ConversationStill from "You Are What You Eat." Credit: NetflixA new Netflix documentary, "You Are What You Eat," showcases sets of identical twins as

Updated on: March 14,2024 5

Netflix's 'You Are What You Eat' uses a twin study. Why studying twins is so important for science

by Nathan Kettlewell,The ConversationStill from "You Are What You Eat." Credit: NetflixA new Netflix documentary, "You Are What You Eat," showcases sets of identical twins as

Updated on:March 14,2024 5

Case study: Drug-resistant bacteria responds to phage-antibiotic combo therapy

FEBRUARY 14, 2024 Editors' notesbyUniversity of PittsburghCredit: CC0 Public DomainIt was a last-ditch effort. For years doctors had tried to keep a patient's recurrent drug-resistant ba

Updated on: March 14,2024 11

Case study: Drug-resistant bacteria responds to phage-antibiotic combo therapy

FEBRUARY 14, 2024 Editors' notesbyUniversity of PittsburghCredit: CC0 Public DomainIt was a last-ditch effort. For years doctors had tried to keep a patient's recurrent drug-resistant ba

Updated on:March 14,2024 11

FDA's plan to ban hair relaxer chemical called too little, too late

FEBRUARY 13, 2024 Editors' notesby Ronnie Cohen, KFF Health NewsCredit: Pixabay/CC0 Public DomainIn April, a dozen years after a federal agency classified formaldehyde a human carcinogen, the Food

Updated on: March 15,2024 12

FDA's plan to ban hair relaxer chemical called too little, too late

FEBRUARY 13, 2024 Editors' notesby Ronnie Cohen, KFF Health NewsCredit: Pixabay/CC0 Public DomainIn April, a dozen years after a federal agency classified formaldehyde a human carcinogen, the Food

Updated on:March 15,2024 12