Study reveals new insights on tissue-dependent roles of JAK signaling in inflammation

byThe Mount Sinai HospitalMice engineered with a patient gene (JAK1 GOF: Neuron) show less lung inflammation, fewer immune cells, and reduced mucous production compared to controls. Credit: Kim

Updated on: December 26,2023 20

Study reveals new insights on tissue-dependent roles of JAK signaling in inflammation

byThe Mount Sinai HospitalMice engineered with a patient gene (JAK1 GOF: Neuron) show less lung inflammation, fewer immune cells, and reduced mucous production compared to controls. Credit: Kim

Updated on:December 26,2023 20

Research offers new insights into how breakdown of omega-6 fatty acids influences metabolism

by Eva Maria Wellnitz, Universitätsmedizin MannheimGeneration and validation of aldh9a1b−/- zebrafish line using CRISPR/Cas9 technology (A) Neighbor-joining phylogenetic bootstrap tree of amino acid s

Updated on: December 26,2023 8

Research offers new insights into how breakdown of omega-6 fatty acids influences metabolism

by Eva Maria Wellnitz, Universitätsmedizin MannheimGeneration and validation of aldh9a1b−/- zebrafish line using CRISPR/Cas9 technology (A) Neighbor-joining phylogenetic bootstrap tree of amino acid s

Updated on:December 26,2023 8

Plastic particles harm gut health and immunity in mice, study shows

by Zhang Nannan,Chinese Academy of SciencesEffect of PS-MNPs on the intestinal structure of mice. Representative images of H&E staining of mouse intestinal tissue. (A) Intestine of mice afte

Updated on: December 26,2023 15

Plastic particles harm gut health and immunity in mice, study shows

by Zhang Nannan,Chinese Academy of SciencesEffect of PS-MNPs on the intestinal structure of mice. Representative images of H&E staining of mouse intestinal tissue. (A) Intestine of mice afte

Updated on:December 26,2023 15

Brain cell discovery sparks hope for fertility treatments

byNagoya UniversityResearchers demonstrated kisspeptin neurons with dynorphin receptors in the brain affects the release of hormones that affect reproductive function in females. Credit: Mayuko

Updated on: December 26,2023 16

Brain cell discovery sparks hope for fertility treatments

byNagoya UniversityResearchers demonstrated kisspeptin neurons with dynorphin receptors in the brain affects the release of hormones that affect reproductive function in females. Credit: Mayuko

Updated on:December 26,2023 16

Mysterious morel mushrooms at center of food poisoning outbreak

by Keely Larson, KFF Health NewsCredit: Unsplash/CC0 Public DomainA food poisoning outbreak that killed two people and sickened 51, stemming from a Montana restaurant, has highlighted just how little

Updated on: December 26,2023 20

Mysterious morel mushrooms at center of food poisoning outbreak

by Keely Larson, KFF Health NewsCredit: Unsplash/CC0 Public DomainA food poisoning outbreak that killed two people and sickened 51, stemming from a Montana restaurant, has highlighted just how little

Updated on:December 26,2023 20

New anti-tumor drug TR128 approved for clinical trial

by Zhang Nannan,Chinese Academy of SciencesCredit: Pixabay/CC0 Public DomainTR128 capsule, a new drug for the treatment of advanced malignant solid tumors, has been approved by the National Medi

Updated on: December 27,2023 9

New anti-tumor drug TR128 approved for clinical trial

by Zhang Nannan,Chinese Academy of SciencesCredit: Pixabay/CC0 Public DomainTR128 capsule, a new drug for the treatment of advanced malignant solid tumors, has been approved by the National Medi

Updated on:December 27,2023 9

Scientists discover surprise anticancer properties of common lab molecule

by UNC HealthIncorporation of thymidine analogs into the human genome and removal of EdU by nucleotide excision repair. (A) Chemical structure of thymidine analogs used in this study. (B) Slot blot as

Updated on: December 27,2023 10

Scientists discover surprise anticancer properties of common lab molecule

by UNC HealthIncorporation of thymidine analogs into the human genome and removal of EdU by nucleotide excision repair. (A) Chemical structure of thymidine analogs used in this study. (B) Slot blot as

Updated on:December 27,2023 10

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on: December 27,2023 12

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on:December 27,2023 12

French pharma firm ordered to pay millions over deadly diabetes drug

Credit: Unsplash/CC0 Public DomainA French appeals court on Wednesday ordered pharmaceutical firm Servier to pay more than $460 million in damages over a scandal involving a diabetes drug linked to hu

Updated on: December 28,2023 5

French pharma firm ordered to pay millions over deadly diabetes drug

Credit: Unsplash/CC0 Public DomainA French appeals court on Wednesday ordered pharmaceutical firm Servier to pay more than $460 million in damages over a scandal involving a diabetes drug linked to hu

Updated on:December 28,2023 5

Common drug for cardiac failure may interfere with debated blood test for Alzheimer's disease

byUniversity of GothenburgChanges in Aβ blood biomarkers following sacubitril/valsartan treatment. Credit:JAMA Neurology(2023). DOI: 10.1001/jamaneurol.2023.4719Researchers from the

Updated on: December 28,2023 10

Common drug for cardiac failure may interfere with debated blood test for Alzheimer's disease

byUniversity of GothenburgChanges in Aβ blood biomarkers following sacubitril/valsartan treatment. Credit:JAMA Neurology(2023). DOI: 10.1001/jamaneurol.2023.4719Researchers from the

Updated on:December 28,2023 10

Researchers develop novel method to improve disease prediction across diverse ancestries

byThe Mount Sinai HospitalBridgePRS improves prediction of African ancestry individuals in the New York BioMe cohort. Credit: Icahn School of Medicine at Mount SinaiA team of scientists from Ica

Updated on: December 28,2023 13

Researchers develop novel method to improve disease prediction across diverse ancestries

byThe Mount Sinai HospitalBridgePRS improves prediction of African ancestry individuals in the New York BioMe cohort. Credit: Icahn School of Medicine at Mount SinaiA team of scientists from Ica

Updated on:December 28,2023 13

Sirtuin 6 activation rescues the age-related decline in DNA damage repair in chondrocytes: Study

by Impact Journals LLCExperimental design for the results shown in Figures 3 and 4. Credit: 2023 Copp et al.A newresearch papertitled "Sirtuin 6 activation rescues the age-related dec

Updated on: December 28,2023 7

Sirtuin 6 activation rescues the age-related decline in DNA damage repair in chondrocytes: Study

by Impact Journals LLCExperimental design for the results shown in Figures 3 and 4. Credit: 2023 Copp et al.A newresearch papertitled "Sirtuin 6 activation rescues the age-related dec

Updated on:December 28,2023 7