Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Updated on: March 28,2024 0

Autophagy-tethering compounds may open new directions in targeted drug discovery

byScience China Press(A) Molecular glue ATTECs are targeting polyQ proteins in neurodegenerative disorders. (B) Bifunctional ATTECs targeting oncoprotein BRD4. (C) Bifunctional ATTECs targeting

Updated on:March 28,2024 0

Shared digital NHS prescribing record could avoid nearly 1 million annual drug errors

byBritish Medical JournalCredit: Pixabay/CC0 Public DomainImplementing a single shared digital prescribing record across the NHS in England could avoid nearly 1 million drug errors every year, s

Updated on: March 28,2024 0

Shared digital NHS prescribing record could avoid nearly 1 million annual drug errors

byBritish Medical JournalCredit: Pixabay/CC0 Public DomainImplementing a single shared digital prescribing record across the NHS in England could avoid nearly 1 million drug errors every year, s

Updated on:March 28,2024 0

FDA approves oral Duvyzat for Duchenne muscular dystrophy

by Lori SolomonThe U.S. Food and Drug Administration has approved Duvyzat (givinostat) as an oral medication for the treatment of Duchenne muscular dystrophy (DMD) in patients six years of age and old

Updated on: March 28,2024 0

FDA approves oral Duvyzat for Duchenne muscular dystrophy

by Lori SolomonThe U.S. Food and Drug Administration has approved Duvyzat (givinostat) as an oral medication for the treatment of Duchenne muscular dystrophy (DMD) in patients six years of age and old

Updated on:March 28,2024 0

Demystifying a key receptor in substance use and neuropsychiatric disorders

byThe Mount Sinai HospitalMount Sinai Icahn scientists took detailed pictures of how drugs can bind to the TAAR1 receptor using CryoEM. They also discovered that an antipsychotic drug, asenapine

Updated on: January 09,2024 9

Demystifying a key receptor in substance use and neuropsychiatric disorders

byThe Mount Sinai HospitalMount Sinai Icahn scientists took detailed pictures of how drugs can bind to the TAAR1 receptor using CryoEM. They also discovered that an antipsychotic drug, asenapine

Updated on:January 09,2024 9

Treating tuberculosis when antibiotics no longer work

byUniversity of CologneCredit:Cell Chemical Biology(2024). DOI: 10.1016/j.chembiol.2023.12.007Researchers have identified new antibiotic molecules that target Mycobacterium tuberculo

Updated on: January 26,2024 20

Treating tuberculosis when antibiotics no longer work

byUniversity of CologneCredit:Cell Chemical Biology(2024). DOI: 10.1016/j.chembiol.2023.12.007Researchers have identified new antibiotic molecules that target Mycobacterium tuberculo

Updated on:January 26,2024 20

The double-edge sword of CRISPR application for in vivo studies

by Impact Journals LLCWorkflow illustration. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28459A new editorial paper titled "The double-edge sword of CRISPR application for in vi

Updated on: January 02,2024 8

The double-edge sword of CRISPR application for in vivo studies

by Impact Journals LLCWorkflow illustration. Credit:Oncotarget(2023). DOI: 10.18632/oncotarget.28459A new editorial paper titled "The double-edge sword of CRISPR application for in vi

Updated on:January 02,2024 8

Study confirms how RNA chemical modifications benefit HIV-1

by Emily Caldwell,The Ohio State UniversityHIV-1 Virus. Credit: J Roberto Trujillo/WikipediaA chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate

Updated on: April 28,2024 0

Study confirms how RNA chemical modifications benefit HIV-1

by Emily Caldwell,The Ohio State UniversityHIV-1 Virus. Credit: J Roberto Trujillo/WikipediaA chemical modification in the HIV-1 RNA genome whose function has been a matter of scientific debate

Updated on:April 28,2024 0

Scientists have figured out how to see through mice—could humans be next?

Scientists have figured out how to see through mice—could humans be next?by Timothy Hearn,The ConversationHow tartrazine made mice see-through under certain light. Credit:ScienceImagine be

Updated on: October 09,2024 0

Scientists have figured out how to see through mice—could humans be next?

Scientists have figured out how to see through mice—could humans be next?by Timothy Hearn,The ConversationHow tartrazine made mice see-through under certain light. Credit:ScienceImagine be

Updated on:October 09,2024 0

Simnotrelvir shortens time to resolution of symptoms in COVID-19

by Elana GotkineFor adults with mild-to-moderate COVID-19, early administration of simnotrelvir plus ritonavir shortens the time to sustained resolution of symptoms, according to a study published in

Updated on: March 21,2024 19

Simnotrelvir shortens time to resolution of symptoms in COVID-19

by Elana GotkineFor adults with mild-to-moderate COVID-19, early administration of simnotrelvir plus ritonavir shortens the time to sustained resolution of symptoms, according to a study published in

Updated on:March 21,2024 19

The dual role of YAP/TAZ in tissue senescence and fibrosis

Updated on: June 05,2024 0

The dual role of YAP/TAZ in tissue senescence and fibrosis

Updated on:June 05,2024 0

Novel compound AC102 restores hearing in preclinical models of sudden hearing loss

by AudioCure Pharma GmbHThe effect of AC102 on OHC survival after noise exposure in vivo. (A) Schematic of OHCs and IHCs within the cochlea. (B) Quantification of OHCs 14 d after noise exposure reveal

Updated on: April 06,2024 0

Novel compound AC102 restores hearing in preclinical models of sudden hearing loss

by AudioCure Pharma GmbHThe effect of AC102 on OHC survival after noise exposure in vivo. (A) Schematic of OHCs and IHCs within the cochlea. (B) Quantification of OHCs 14 d after noise exposure reveal

Updated on:April 06,2024 0

‘Harvard Thinking’: Plastics are everywhere, even in our bodies

Updated on: October 29,2024 0

‘Harvard Thinking’: Plastics are everywhere, even in our bodies

Updated on:October 29,2024 0