Alzheimer's risk gene disrupts endocytosis, but another disease-linked gene could help

by Massachusetts Institute of TechnologyAPOE4 Astrocytes showed an increase in endocytosis after overexpression of PICALM. In the bottom row, astrocytes (labeled blue), have taken up more of a pr

Updated on: April 07,2024 18

Alzheimer's risk gene disrupts endocytosis, but another disease-linked gene could help

by Massachusetts Institute of TechnologyAPOE4 Astrocytes showed an increase in endocytosis after overexpression of PICALM. In the bottom row, astrocytes (labeled blue), have taken up more of a pr

Updated on:April 07,2024 18

New insights into Niemann-Pick type C: A form of childhood dementia

by Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)Bone marrow-derived macrophages (BMDMs) share key molecular and functional alterations observed in NPC1-deficient microglia. Credit:&

Updated on: December 17,2024 0

New insights into Niemann-Pick type C: A form of childhood dementia

by Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)Bone marrow-derived macrophages (BMDMs) share key molecular and functional alterations observed in NPC1-deficient microglia. Credit:&

Updated on:December 17,2024 0

Scientists uncover new biallelic repeat expansion leading to mitochondrial encephalopathy

by Juntendo University Research Promotion CenterCredit:npj Genomic Medicine(2024). DOI: 10.1038/s41525-024-00429-5Mitochondrial diseases are among the most prevalent hereditary metabolic d

Updated on: November 22,2024 0

Scientists uncover new biallelic repeat expansion leading to mitochondrial encephalopathy

by Juntendo University Research Promotion CenterCredit:npj Genomic Medicine(2024). DOI: 10.1038/s41525-024-00429-5Mitochondrial diseases are among the most prevalent hereditary metabolic d

Updated on:November 22,2024 0

Cognitive flexibility: How neural variability shapes decision-making in different brains

by Tejasri Gururaj , Medical XpressNeural computations underlying flexible decision-making in rats. Credit: Dr. Marino PaganResearchpublishedinNaturehas revealed that neural co

Updated on: January 14,2025 0

Cognitive flexibility: How neural variability shapes decision-making in different brains

by Tejasri Gururaj , Medical XpressNeural computations underlying flexible decision-making in rats. Credit: Dr. Marino PaganResearchpublishedinNaturehas revealed that neural co

Updated on:January 14,2025 0

New pathway in Alzheimer's disease provides earlier target for potential therapies

by Case Western Reserve UniversityCredit: CC0 Public DomainResearchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's dis

Updated on: April 07,2024 16

New pathway in Alzheimer's disease provides earlier target for potential therapies

by Case Western Reserve UniversityCredit: CC0 Public DomainResearchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's dis

Updated on:April 07,2024 16

How experience shapes hippocampal place cell activity to create flexible cognitive maps

Updated on: May 15,2025 0

How experience shapes hippocampal place cell activity to create flexible cognitive maps

Updated on:May 15,2025 0

Atomic force microscopy in the characterization and clinical evaluation of neurological disorders

by Shanghai Jiao Tong University Journal CenterAFM has unique capabilities in neurobiology for detailed biomechanical analysis of brain tissues and cells, and also has clinical potential in diagnosing

Updated on: July 17,2024 0

Atomic force microscopy in the characterization and clinical evaluation of neurological disorders

by Shanghai Jiao Tong University Journal CenterAFM has unique capabilities in neurobiology for detailed biomechanical analysis of brain tissues and cells, and also has clinical potential in diagnosing

Updated on:July 17,2024 0

AI-generated content model applied to brain image computing for Alzheimer's disease analysis

by Liu Jia,Chinese Academy of SciencesCredit: Pixabay/CC0 Public DomainGenerative artificial intelligence (AI), utilizing deep learning to generate a patient's brain network from multimodal

Updated on: March 08,2024 15

AI-generated content model applied to brain image computing for Alzheimer's disease analysis

by Liu Jia,Chinese Academy of SciencesCredit: Pixabay/CC0 Public DomainGenerative artificial intelligence (AI), utilizing deep learning to generate a patient's brain network from multimodal

Updated on:March 08,2024 15

MouseGoggles offer immersive look into neural activity

MouseGoggles offer immersive look into neural activityby David Nutt,Cornell UniversityCornell researchers built miniature VR headsets to immerse mice more deeply in virtual environments that can

Updated on: January 18,2025 0

MouseGoggles offer immersive look into neural activity

MouseGoggles offer immersive look into neural activityby David Nutt,Cornell UniversityCornell researchers built miniature VR headsets to immerse mice more deeply in virtual environments that can

Updated on:January 18,2025 0

Alzheimer-linked enzyme complex 'buckles up' for safe trip through the cell

by VIB (the Flanders Institute for Biotechnology)Credit: Opabinia regalis, CC BY-SA 4.0A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protei

Updated on: April 10,2024 20

Alzheimer-linked enzyme complex 'buckles up' for safe trip through the cell

by VIB (the Flanders Institute for Biotechnology)Credit: Opabinia regalis, CC BY-SA 4.0A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protei

Updated on:April 10,2024 20

Singing is beneficial for memory and mood especially in early dementia

by IOS PressResearchers led by Dr. Teppo Särkämö at University of Helsinki, Finland have revealed that caregiver-implemented musical leisure activities, particularly singing, are cognitively and

Updated on: February 27,2024 15

Singing is beneficial for memory and mood especially in early dementia

by IOS PressResearchers led by Dr. Teppo Särkämö at University of Helsinki, Finland have revealed that caregiver-implemented musical leisure activities, particularly singing, are cognitively and

Updated on:February 27,2024 15

Psychiatric symptoms in Alzheimer´s disease

by Lund UniversityCredit: Pixabay/CC0 Public DomainIn addition to memory problems and other cognitive symptoms, most people with Alzheimer's disease also suffer from mental health issues. It

Updated on: April 07,2024 15

Psychiatric symptoms in Alzheimer´s disease

by Lund UniversityCredit: Pixabay/CC0 Public DomainIn addition to memory problems and other cognitive symptoms, most people with Alzheimer's disease also suffer from mental health issues. It

Updated on:April 07,2024 15