Potential Alzheimer's medication shows promise in mouse model of neurodegenerative disease

by JCI JournalsMemory loss and other cognitive symptoms of Alzheimer's disease are attributed, in part, to the degeneration of acetylcholine-producing neurons. Acetylcholinesterase inhibitors are

Updated on: March 07,2024

Potential Alzheimer's medication shows promise in mouse model of neurodegenerative disease

by JCI JournalsMemory loss and other cognitive symptoms of Alzheimer's disease are attributed, in part, to the degeneration of acetylcholine-producing neurons. Acetylcholinesterase inhibitors are

Updated on:March 07,2024

Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on: July 01,2024

Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on:July 01,2024

LSL60101 compound reduces neuroinflammation and improves cognition

by University of BarcelonaCredit: Pixabay/CC0 Public DomainThe LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies a

Updated on: March 30,2024

LSL60101 compound reduces neuroinflammation and improves cognition

by University of BarcelonaCredit: Pixabay/CC0 Public DomainThe LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies a

Updated on:March 30,2024

Risk for dementia reduced in association with antihypertensive use

by Elana GotkineAntihypertensive use is associated with a reduced risk for dementia compared with untreated hypertension, according to research published online Sept. 12 inJAMA Network Open.Matt

Updated on: March 02,2024

Risk for dementia reduced in association with antihypertensive use

by Elana GotkineAntihypertensive use is associated with a reduced risk for dementia compared with untreated hypertension, according to research published online Sept. 12 inJAMA Network Open.Matt

Updated on:March 02,2024

Could blood pressure drugs have a role in Alzheimer's disease treatment?

by Georgetown University Medical CenterDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.In laboratory neuronal cultures, an FDA-approved drug used to

Updated on: February 27,2024

Could blood pressure drugs have a role in Alzheimer's disease treatment?

by Georgetown University Medical CenterDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.In laboratory neuronal cultures, an FDA-approved drug used to

Updated on:February 27,2024

The way the brain processes speech could serve as a predictor of early dementia

by Baycrest Centre for Geriatric CareCredit: CC0 Public DomainEarly dementia is typically associated with memory and thinking problems; but older adults should also be vigilant about hearing and

Updated on: May 13,2024

The way the brain processes speech could serve as a predictor of early dementia

by Baycrest Centre for Geriatric CareCredit: CC0 Public DomainEarly dementia is typically associated with memory and thinking problems; but older adults should also be vigilant about hearing and

Updated on:May 13,2024

Prenatal pollution linked to lower cognitive scores in infants

by Lisa Marshall,University of Colorado at BoulderAssociations Between Prenatal PM10Exposure and Composite Cognitive, Motor, and Language Scores at 2 Years. Average prenatal exposure to PM

Updated on: February 03,2024

Prenatal pollution linked to lower cognitive scores in infants

by Lisa Marshall,University of Colorado at BoulderAssociations Between Prenatal PM10Exposure and Composite Cognitive, Motor, and Language Scores at 2 Years. Average prenatal exposure to PM

Updated on:February 03,2024

Tau does not stabilize microtubules, challenges approach to treating Alzheimer's

by Drexel UniversityThis image represents the role of tau and MAP6 in regulating the stable (green) and dynamic (red) parts of a neuron's microtubules. Depleting tau from cultured rat neurons

Updated on: April 02,2024

Tau does not stabilize microtubules, challenges approach to treating Alzheimer's

by Drexel UniversityThis image represents the role of tau and MAP6 in regulating the stable (green) and dynamic (red) parts of a neuron's microtubules. Depleting tau from cultured rat neurons

Updated on:April 02,2024

Mouse study finds sex-based differences in how brains handle threats

Mouse study finds sex-based differences in how brains handle threatsby Claire Loewen,McGill UniversityMales and females similarly acquire threat discrimination. Credit:Nature Neuroscience&

Updated on: September 23,2024

Mouse study finds sex-based differences in how brains handle threats

Mouse study finds sex-based differences in how brains handle threatsby Claire Loewen,McGill UniversityMales and females similarly acquire threat discrimination. Credit:Nature Neuroscience&

Updated on:September 23,2024

Alzheimer's missing link ID'd, answering what tips brain's decline

by Washington University School of MedicineIn Alzheimer's, amyloid clumps (blue) develop first in the brain, followed by tangles of the protein tau (red). Tau is associated with memory loss a

Updated on: April 20,2024

Alzheimer's missing link ID'd, answering what tips brain's decline

by Washington University School of MedicineIn Alzheimer's, amyloid clumps (blue) develop first in the brain, followed by tangles of the protein tau (red). Tau is associated with memory loss a

Updated on:April 20,2024

Yeast protein could offer clues to how Alzheimer's plaques form in the brain

by Anne Trafton,Massachusetts Institute of TechnologyMIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s dise

Updated on: February 26,2024

Yeast protein could offer clues to how Alzheimer's plaques form in the brain

by Anne Trafton,Massachusetts Institute of TechnologyMIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s dise

Updated on:February 26,2024

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on: April 16,2024

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on:April 16,2024