Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on: April 02,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on:April 02,2024

Machine-learning program reveals genes responsible for sex-specific differences in Alzheimer's disease progression

by Texas Children's HospitalThe top 98 EAML genes are connected to GWAS genes, dysregulated in AD patients, and capable of separating AD and healthy control samples. Credit:Nature Commu

Updated on: June 11,2024

Machine-learning program reveals genes responsible for sex-specific differences in Alzheimer's disease progression

by Texas Children's HospitalThe top 98 EAML genes are connected to GWAS genes, dysregulated in AD patients, and capable of separating AD and healthy control samples. Credit:Nature Commu

Updated on:June 11,2024

Dementia rates more than 20% higher among black adults than UK average

by University College LondonCrude dementia prevalence (95% CI) in those aged 65 and over, by ethnic group. Credit:Alzheimer's & Dementia(2022). DOI: 10.1002/alz.12774Dementia

Updated on: June 07,2024

Dementia rates more than 20% higher among black adults than UK average

by University College LondonCrude dementia prevalence (95% CI) in those aged 65 and over, by ethnic group. Credit:Alzheimer's & Dementia(2022). DOI: 10.1002/alz.12774Dementia

Updated on:June 07,2024

Researchers investigate roles of orexin in energy metabolism during sleep in humans

byUniversity of TsukubaEEG record during indirect calorimetry using a whole room metabolic chamber. Credit: University of TsukubaOrexin, named after its role in feeding regulation, is a potent e

Updated on: July 06,2024

Researchers investigate roles of orexin in energy metabolism during sleep in humans

byUniversity of TsukubaEEG record during indirect calorimetry using a whole room metabolic chamber. Credit: University of TsukubaOrexin, named after its role in feeding regulation, is a potent e

Updated on:July 06,2024

Genes expressed in the brain before birth may affect risk of childhood mental illness

by Massachusetts General HospitalCredit: Pixabay/CC0 Public DomainResearchers have identified various genes whose expression in the brain before birth may affect the risk of developing a range of

Updated on: February 03,2024

Genes expressed in the brain before birth may affect risk of childhood mental illness

by Massachusetts General HospitalCredit: Pixabay/CC0 Public DomainResearchers have identified various genes whose expression in the brain before birth may affect the risk of developing a range of

Updated on:February 03,2024

New tool can detect tiny protein clumps associated with neurodegenerative disorders

by University of CopenhagenInsulin proteins clumping together. Credit: Jacob Kæstel-HansenThe clumping of proteins is at the root of a wide range of neurodegenerative disorders that affect the br

Updated on: June 15,2024

New tool can detect tiny protein clumps associated with neurodegenerative disorders

by University of CopenhagenInsulin proteins clumping together. Credit: Jacob Kæstel-HansenThe clumping of proteins is at the root of a wide range of neurodegenerative disorders that affect the br

Updated on:June 15,2024

Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on: July 25,2024

Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on:July 25,2024

Big data analysis powers the fight against Alzheimer's

by Rita Steyn,Pacific Northwest National LaboratoryA PNNL technician studies a brain tissue sample. Credit: Andrea Starr / Pacific Northwest National LaboratoryAlzheimer's disease has always

Updated on: May 22,2024

Big data analysis powers the fight against Alzheimer's

by Rita Steyn,Pacific Northwest National LaboratoryA PNNL technician studies a brain tissue sample. Credit: Andrea Starr / Pacific Northwest National LaboratoryAlzheimer's disease has always

Updated on:May 22,2024

Researchers: Lifestyle changes can reduce dementia risk by maintaining brain plasticity, but the time to act is now

by Saskia Sivananthan and Laura Middleton,The ConversationCredit: CC0 Public DomainWalk 10,000 steps a day, cut back alcohol, get better sleep at night, stay socially active—we're told that

Updated on: February 24,2024

Researchers: Lifestyle changes can reduce dementia risk by maintaining brain plasticity, but the time to act is now

by Saskia Sivananthan and Laura Middleton,The ConversationCredit: CC0 Public DomainWalk 10,000 steps a day, cut back alcohol, get better sleep at night, stay socially active—we're told that

Updated on:February 24,2024

Genetic changes differed, increased in people with Alzheimer's disease

by Brigham and Women's HospitalCredit: Public DomainInside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer's disease, these errors—known as somatic mut

Updated on: June 14,2024

Genetic changes differed, increased in people with Alzheimer's disease

by Brigham and Women's HospitalCredit: Public DomainInside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer's disease, these errors—known as somatic mut

Updated on:June 14,2024

Imprinted genes in the 'parenting hub' of the brain determine if mice are good parents, new study finds

byPublic Library of ScienceCredit: Pixabay/CC0 Public DomainWhether a mouse is a good or bad parent can be traced back to imprinted genes in key neurons in the "parenting hub" in the b

Updated on: January 12,2024

Imprinted genes in the 'parenting hub' of the brain determine if mice are good parents, new study finds

byPublic Library of ScienceCredit: Pixabay/CC0 Public DomainWhether a mouse is a good or bad parent can be traced back to imprinted genes in key neurons in the "parenting hub" in the b

Updated on:January 12,2024

Tips to making your home safer for people with Alzheimer's

by Ernie MundellBright lights, loud sounds and trip hazards can make a person with Alzheimer's uncomfortable in the home and even pose real dangers.The Alzheimer's Foundation of America (AFA)

Updated on: June 15,2024

Tips to making your home safer for people with Alzheimer's

by Ernie MundellBright lights, loud sounds and trip hazards can make a person with Alzheimer's uncomfortable in the home and even pose real dangers.The Alzheimer's Foundation of America (AFA)

Updated on:June 15,2024