Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on: July 25,2024

Study finds siRNA ineffective in reducing mutant huntingtin gene mRNA in nucleus

byMary Ann Liebert, IncHuntingtin. Crystallographic structure of the N-terminal region of the human Huntingtin protein with an artificially attached Maltose-Binding protein used for crystallogra

Updated on:July 25,2024

How sensory neurons impact the gut

by The Scripps Research InstituteResearchers showed that PIEZO2 receptors in sensory neurons control the rate of gut transit. In this fluorescently stained microscopy image, nerve endings stemmin

Updated on: June 20,2024

How sensory neurons impact the gut

by The Scripps Research InstituteResearchers showed that PIEZO2 receptors in sensory neurons control the rate of gut transit. In this fluorescently stained microscopy image, nerve endings stemmin

Updated on:June 20,2024

How the brain coordinates speaking and breathing

by Massachusetts Institute of TechnologyCredit: Pixabay/CC0 Public DomainMIT researchers have discovered a brain circuit that drives vocalization and ensures that you talk only when you breathe o

Updated on: March 19,2024

How the brain coordinates speaking and breathing

by Massachusetts Institute of TechnologyCredit: Pixabay/CC0 Public DomainMIT researchers have discovered a brain circuit that drives vocalization and ensures that you talk only when you breathe o

Updated on:March 19,2024

Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease

by Heinrich-Heine University DuesseldorfCross section of the 3D model of an amyloid fibril against the backdrop of a cryo-electron microscopy recording. A PI3K SH3 domain is highlighted in yellow. Cre

Updated on: May 20,2024

Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease

by Heinrich-Heine University DuesseldorfCross section of the 3D model of an amyloid fibril against the backdrop of a cryo-electron microscopy recording. A PI3K SH3 domain is highlighted in yellow. Cre

Updated on:May 20,2024

New tool can detect tiny protein clumps associated with neurodegenerative disorders

by University of CopenhagenInsulin proteins clumping together. Credit: Jacob Kæstel-HansenThe clumping of proteins is at the root of a wide range of neurodegenerative disorders that affect the br

Updated on: June 15,2024

New tool can detect tiny protein clumps associated with neurodegenerative disorders

by University of CopenhagenInsulin proteins clumping together. Credit: Jacob Kæstel-HansenThe clumping of proteins is at the root of a wide range of neurodegenerative disorders that affect the br

Updated on:June 15,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on: April 02,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on:April 02,2024

Nanoscopic motor proteins in the brain build the physical structures of memory, study finds

by Albert HiuKa Fok,The ConversationCredit:Cell Reports(2024). DOI: 10.1016/j.celrep.2024.113906The puzzle of memory has intrigued philosophers and intellects for a very long time. P

Updated on: July 06,2024

Nanoscopic motor proteins in the brain build the physical structures of memory, study finds

by Albert HiuKa Fok,The ConversationCredit:Cell Reports(2024). DOI: 10.1016/j.celrep.2024.113906The puzzle of memory has intrigued philosophers and intellects for a very long time. P

Updated on:July 06,2024

Halloween can be a scary time for people with dementia. Here's how to help

by Cara MurezWhen there are suddenly creepy decorations and lots of knocks at the door from strangers, Halloween can be frightening for someone living withdementia.It is possible to keep a loved

Updated on: May 26,2024

Halloween can be a scary time for people with dementia. Here's how to help

by Cara MurezWhen there are suddenly creepy decorations and lots of knocks at the door from strangers, Halloween can be frightening for someone living withdementia.It is possible to keep a loved

Updated on:May 26,2024

Genetic changes differed, increased in people with Alzheimer's disease

by Brigham and Women's HospitalCredit: Public DomainInside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer's disease, these errors—known as somatic mut

Updated on: June 14,2024

Genetic changes differed, increased in people with Alzheimer's disease

by Brigham and Women's HospitalCredit: Public DomainInside brain cells, errors in DNA can accumulate as we age. But in patients with Alzheimer's disease, these errors—known as somatic mut

Updated on:June 14,2024

Study reveals how, when and where non-invasive brain stimulation influences neuronal activity and cognition

byMonash UniversityOverall response time modulations in humans and in monkeys. Credit:Brain(2024). DOI: 10.1093/brain/awae273Brain stimulation using electrodes placed on the head has

Updated on: September 23,2024

Study reveals how, when and where non-invasive brain stimulation influences neuronal activity and cognition

byMonash UniversityOverall response time modulations in humans and in monkeys. Credit:Brain(2024). DOI: 10.1093/brain/awae273Brain stimulation using electrodes placed on the head has

Updated on:September 23,2024

Neurosurgeon explains the difference in brain aneurysms

by Deb Balzer, Mayo Clinic News NetworkCredit: CC0 Public DomainEach year, nearly half a million people worldwide die from brain aneurysms. In the U.S., an estimated 6.7 million people have an unruptu

Updated on: March 28,2024

Neurosurgeon explains the difference in brain aneurysms

by Deb Balzer, Mayo Clinic News NetworkCredit: CC0 Public DomainEach year, nearly half a million people worldwide die from brain aneurysms. In the U.S., an estimated 6.7 million people have an unruptu

Updated on:March 28,2024

New studies suggest millions with mild cognitive impairment go undiagnosed, often until it's too late

by Soeren Mattke and Ying Liu,The ConversationCredit: Pixabay/CC0 Public DomainMild cognitive impairment—an early stage of dementia—is widely underdiagnosed in people 65 and older. That is the k

Updated on: March 28,2024

New studies suggest millions with mild cognitive impairment go undiagnosed, often until it's too late

by Soeren Mattke and Ying Liu,The ConversationCredit: Pixabay/CC0 Public DomainMild cognitive impairment—an early stage of dementia—is widely underdiagnosed in people 65 and older. That is the k

Updated on:March 28,2024