A new mechanism for crossing the blood–brain barrier

by Lori Dajose,California Institute of TechnologyCA-IV is required for the CNS potency of Car4-dependent AAV. (A) Immunostaining for CA-IV in the brains of WT/WT and KO/KO Car4 mice. Magnified r

Updated on: February 05,2024 18

A new mechanism for crossing the blood–brain barrier

by Lori Dajose,California Institute of TechnologyCA-IV is required for the CNS potency of Car4-dependent AAV. (A) Immunostaining for CA-IV in the brains of WT/WT and KO/KO Car4 mice. Magnified r

Updated on:February 05,2024 18

Alzheimer's disease risk gene APOE4 impairs function of brain immune cells

by University of Eastern FinlandThe induced pluripotent stem cell (iPSC) -derived microglia demonstrate that apolipoprotein E4 (APOE4) has a profound impact on several functions of human brain im

Updated on: April 08,2024 18

Alzheimer's disease risk gene APOE4 impairs function of brain immune cells

by University of Eastern FinlandThe induced pluripotent stem cell (iPSC) -derived microglia demonstrate that apolipoprotein E4 (APOE4) has a profound impact on several functions of human brain im

Updated on:April 08,2024 18

Study discovers connection between between heart and brain in KBG syndrome

byUniversity of AlbertaAnkrd11is expressed in cardiac neural crest cells and ablated in theAnkrd11nckomouse model. Credit:Nature Communications(2024). DOI: 10.1038/

Updated on: July 05,2024 0

Study discovers connection between between heart and brain in KBG syndrome

byUniversity of AlbertaAnkrd11is expressed in cardiac neural crest cells and ablated in theAnkrd11nckomouse model. Credit:Nature Communications(2024). DOI: 10.1038/

Updated on:July 05,2024 0

Stimulating the hypothalamus can restore walking in paralyzed patients, study shows

byEcole Polytechnique Federale de LausanneDBSLHmediates immediate improvements in walking in humans with SCI. Credit:Nature Medicine(2024). DOI: 10.1038/s41591-024-03306-xResea

Updated on: December 18,2024 0

Stimulating the hypothalamus can restore walking in paralyzed patients, study shows

byEcole Polytechnique Federale de LausanneDBSLHmediates immediate improvements in walking in humans with SCI. Credit:Nature Medicine(2024). DOI: 10.1038/s41591-024-03306-xResea

Updated on:December 18,2024 0

Study associates reduced activity of a key enzyme with microcephaly in Zika-infected offspring

byFAPESPCredit:Journal of Neurochemistry(2023). DOI: 10.1111/jnc.15918Mice that were infected with Zika virus during pregnancy and developed microcephaly displayed less activity of N

Updated on: January 11,2024 9

Study associates reduced activity of a key enzyme with microcephaly in Zika-infected offspring

byFAPESPCredit:Journal of Neurochemistry(2023). DOI: 10.1111/jnc.15918Mice that were infected with Zika virus during pregnancy and developed microcephaly displayed less activity of N

Updated on:January 11,2024 9

Is Alzheimer's caused by disruptions to the brain's energy supply?

by Kira Shaw And Orla Bonnar,The ConversationCredit: AI-generated imageIt is well known that Alzheimer's disease, the most common form of dementia, involves the accumulation of sticky protei

Updated on: April 20,2024 0

Is Alzheimer's caused by disruptions to the brain's energy supply?

by Kira Shaw And Orla Bonnar,The ConversationCredit: AI-generated imageIt is well known that Alzheimer's disease, the most common form of dementia, involves the accumulation of sticky protei

Updated on:April 20,2024 0

Tips to making your home safer for people with Alzheimer's

by Ernie MundellBright lights, loud sounds and trip hazards can make a person with Alzheimer's uncomfortable in the home and even pose real dangers.The Alzheimer's Foundation of America (AFA)

Updated on: June 15,2024 5

Tips to making your home safer for people with Alzheimer's

by Ernie MundellBright lights, loud sounds and trip hazards can make a person with Alzheimer's uncomfortable in the home and even pose real dangers.The Alzheimer's Foundation of America (AFA)

Updated on:June 15,2024 5

New study reveals key role vision plays in sculpting brain development

by Jake Siegel,Allen Institute for Brain ScienceMara Rue, Ph.D., co-lead author and scientist at the Allen Institute for Brain Science. Credit: Peter Kim/Allen InstituteScientists have long know

Updated on: April 28,2024 0

New study reveals key role vision plays in sculpting brain development

by Jake Siegel,Allen Institute for Brain ScienceMara Rue, Ph.D., co-lead author and scientist at the Allen Institute for Brain Science. Credit: Peter Kim/Allen InstituteScientists have long know

Updated on:April 28,2024 0

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on: March 25,2024 18

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on:March 25,2024 18

ssResearchers identify key steps to toxic protein accumulation in Alzheimer's and other diseases

by Tamara Bhandari,Washington University School of Medicine in St. LouisStress granules (red) fill stem cell-derived neurons (nuclei shown in blue) from a person with a mutation in the tau gene.

Updated on: March 02,2024 18

ssResearchers identify key steps to toxic protein accumulation in Alzheimer's and other diseases

by Tamara Bhandari,Washington University School of Medicine in St. LouisStress granules (red) fill stem cell-derived neurons (nuclei shown in blue) from a person with a mutation in the tau gene.

Updated on:March 02,2024 18

Low-carb 'keto' diet ('Atkins-style') may modestly improve cognition in older adults

by Johns Hopkins University School of MedicineCredit: CC0 Public DomainIn a pilot study of 14 older adults with mild cognitive problems suggestive of early Alzheimer's disease, Johns Hopkins

Updated on: May 22,2024 8

Low-carb 'keto' diet ('Atkins-style') may modestly improve cognition in older adults

by Johns Hopkins University School of MedicineCredit: CC0 Public DomainIn a pilot study of 14 older adults with mild cognitive problems suggestive of early Alzheimer's disease, Johns Hopkins

Updated on:May 22,2024 8

Couples and young-onset dementia: Study of coping offers hope for new interventions

by Massachusetts General HospitalCredit: CC0 Public DomainResearchers from Massachusetts General Hospital (MGH) have used a couples-based framework to describe the experiences of individuals diag

Updated on: June 01,2024 5

Couples and young-onset dementia: Study of coping offers hope for new interventions

by Massachusetts General HospitalCredit: CC0 Public DomainResearchers from Massachusetts General Hospital (MGH) have used a couples-based framework to describe the experiences of individuals diag

Updated on:June 01,2024 5