Antibody therapy inspired by patient case reduces tau tangles in a preclinical model of Alzheimer's disease

by Mass General BrighamCredit: Pixabay/Pete Linforth.A team led by researchers from Mass General Brigham reports promising results for a monoclonal antibody that takes aim at a new target for Alz

Updated on: March 02,2024

Antibody therapy inspired by patient case reduces tau tangles in a preclinical model of Alzheimer's disease

by Mass General BrighamCredit: Pixabay/Pete Linforth.A team led by researchers from Mass General Brigham reports promising results for a monoclonal antibody that takes aim at a new target for Alz

Updated on:March 02,2024

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on: January 11,2024

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on:January 11,2024

How the discovery of an Alzheimer's tipping point could improve drug trials

by Robin Marks,University of California, San FranciscoDormant tau proteins in the brain's memory centers (red) are spurred to spread as amyloid beta (blue) develops in the neocortex. When th

Updated on: April 20,2024

How the discovery of an Alzheimer's tipping point could improve drug trials

by Robin Marks,University of California, San FranciscoDormant tau proteins in the brain's memory centers (red) are spurred to spread as amyloid beta (blue) develops in the neocortex. When th

Updated on:April 20,2024

'Not enough therapists': Georgia lawmakers aim to support mental health workforce

by Michelle Baruchman, The Atlanta Journal-ConstitutionCredit: Pixabay/CC0 Public DomainDuring the COVID-19 pandemic, more than 1,200 state psychiatric hospital employees left their positions, and jus

Updated on: March 19,2024

'Not enough therapists': Georgia lawmakers aim to support mental health workforce

by Michelle Baruchman, The Atlanta Journal-ConstitutionCredit: Pixabay/CC0 Public DomainDuring the COVID-19 pandemic, more than 1,200 state psychiatric hospital employees left their positions, and jus

Updated on:March 19,2024

Breaking stereotype: Brain models are not one-size-fits-all

by Yale UniversityCredit: Pixabay/CC0 Public DomainMachine learning has helped scientists understand how the brain gives rise to complex human characteristics, uncovering patterns of brain activi

Updated on: February 18,2024

Breaking stereotype: Brain models are not one-size-fits-all

by Yale UniversityCredit: Pixabay/CC0 Public DomainMachine learning has helped scientists understand how the brain gives rise to complex human characteristics, uncovering patterns of brain activi

Updated on:February 18,2024

Risk factors for Parkinson's disease: Study proves the protective function of the RIT2 gene

by Eurac ResearchIn vivo aSyn overexpression increases endogenous LRRK2 activity, which is prevented by Rit2 co-expression.aPLA analysis of AAV-GFP, AAV-A53T-aSyn and AAV-A53T-aSyn + AAV-R

Updated on: June 17,2024

Risk factors for Parkinson's disease: Study proves the protective function of the RIT2 gene

by Eurac ResearchIn vivo aSyn overexpression increases endogenous LRRK2 activity, which is prevented by Rit2 co-expression.aPLA analysis of AAV-GFP, AAV-A53T-aSyn and AAV-A53T-aSyn + AAV-R

Updated on:June 17,2024

Alzheimer's treatment holds promise for primary progressive aphasia patients

by Northwestern UniversityCredit: CC0 Public DomainNorthwestern Medicine scientists have discovered that an existing therapy frequently used to treat Alzheimer's disease might also work on pa

Updated on: April 08,2024

Alzheimer's treatment holds promise for primary progressive aphasia patients

by Northwestern UniversityCredit: CC0 Public DomainNorthwestern Medicine scientists have discovered that an existing therapy frequently used to treat Alzheimer's disease might also work on pa

Updated on:April 08,2024

Three-minute test detects common form of dementia that's hard to diagnose

by Florida Atlantic UniversityJames E. Galvin, M.D., M.P.H., one of the most prominent neuroscientists in the country, and a professor in FAU's Charles E. Schmidt College of Medicine and Chri

Updated on: February 26,2024

Three-minute test detects common form of dementia that's hard to diagnose

by Florida Atlantic UniversityJames E. Galvin, M.D., M.P.H., one of the most prominent neuroscientists in the country, and a professor in FAU's Charles E. Schmidt College of Medicine and Chri

Updated on:February 26,2024

Researchers discover a new face-detecting brain circuit

byNational Eye InstituteGongchen Yu, Ph.D., Leor Katz, Ph.D., and Richard Krauzlis, Ph.D. Credit: Dustin Hays, National Eye InstituteScientists at the National Institutes of Health (NIH) have un

Updated on: July 05,2024

Researchers discover a new face-detecting brain circuit

byNational Eye InstituteGongchen Yu, Ph.D., Leor Katz, Ph.D., and Richard Krauzlis, Ph.D. Credit: Dustin Hays, National Eye InstituteScientists at the National Institutes of Health (NIH) have un

Updated on:July 05,2024

Alzheimer's disease raises the risk of severe COVID-19 and death from this viral disease

by Elton Alisson,FAPESPPatients with dementia and especially Alzheimer’s run a threefold risk of dying as a result of infection by SARS-CoV-2. The risk is six times greater if they are over 80,

Updated on: April 16,2024

Alzheimer's disease raises the risk of severe COVID-19 and death from this viral disease

by Elton Alisson,FAPESPPatients with dementia and especially Alzheimer’s run a threefold risk of dying as a result of infection by SARS-CoV-2. The risk is six times greater if they are over 80,

Updated on:April 16,2024

Restoring brain function in mice with symptoms of Alzheimer's disease

by Johns Hopkins University School of MedicineCredit: CC0 Public DomainA study in mice shows that selectively removing cells that are no longer dividing from the brains of mice with a form of Alz

Updated on: June 11,2024

Restoring brain function in mice with symptoms of Alzheimer's disease

by Johns Hopkins University School of MedicineCredit: CC0 Public DomainA study in mice shows that selectively removing cells that are no longer dividing from the brains of mice with a form of Alz

Updated on:June 11,2024

Tau hot spots open new avenues of discovery into dementia

by Queensland Brain InstituteRepresentative diffraction-limited image of a neuroblastoma cell expressing Tau-mEos3.2 molecules acquired in the green channel before single-molecule imaging. Credit: Dr

Updated on: April 02,2024

Tau hot spots open new avenues of discovery into dementia

by Queensland Brain InstituteRepresentative diffraction-limited image of a neuroblastoma cell expressing Tau-mEos3.2 molecules acquired in the green channel before single-molecule imaging. Credit: Dr

Updated on:April 02,2024