New insights into the formation of toxic protein clumps in Alzheimer's disease

byForschungszentrum JuelichSmall Aβ oligomers (left: cryo-electron microscopy) are clumps consisting of just a few Aβ molecules. They cluster together to form short, worm-like structures known a

Updated on: April 18,2024

New insights into the formation of toxic protein clumps in Alzheimer's disease

byForschungszentrum JuelichSmall Aβ oligomers (left: cryo-electron microscopy) are clumps consisting of just a few Aβ molecules. They cluster together to form short, worm-like structures known a

Updated on:April 18,2024

Gene therapy using 'zinc fingers' may help treat Alzheimer's disease, animal study shows

by Massachusetts General HospitalCredit: Pixabay/CC0 Public DomainResearchers have used a genetic engineering strategy to dramatically reduce levels of tau—a key protein that accumulates and beco

Updated on: May 22,2024

Gene therapy using 'zinc fingers' may help treat Alzheimer's disease, animal study shows

by Massachusetts General HospitalCredit: Pixabay/CC0 Public DomainResearchers have used a genetic engineering strategy to dramatically reduce levels of tau—a key protein that accumulates and beco

Updated on:May 22,2024

Seizures in Alzheimer's mouse model disrupt adult neurogenesis

by Baylor College of MedicineDr. Jeannie Chin. Credit: Baylor College of MedicineMemory impairment and mood changes are typically observed in patients with Alzheimer's disease but what distur

Updated on: April 20,2024

Seizures in Alzheimer's mouse model disrupt adult neurogenesis

by Baylor College of MedicineDr. Jeannie Chin. Credit: Baylor College of MedicineMemory impairment and mood changes are typically observed in patients with Alzheimer's disease but what distur

Updated on:April 20,2024

Risk factors for Parkinson's disease: Study proves the protective function of the RIT2 gene

by Eurac ResearchIn vivo aSyn overexpression increases endogenous LRRK2 activity, which is prevented by Rit2 co-expression.aPLA analysis of AAV-GFP, AAV-A53T-aSyn and AAV-A53T-aSyn + AAV-R

Updated on: June 17,2024

Risk factors for Parkinson's disease: Study proves the protective function of the RIT2 gene

by Eurac ResearchIn vivo aSyn overexpression increases endogenous LRRK2 activity, which is prevented by Rit2 co-expression.aPLA analysis of AAV-GFP, AAV-A53T-aSyn and AAV-A53T-aSyn + AAV-R

Updated on:June 17,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on: April 02,2024

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease

by Elana GotkineFor patients with preclinical Alzheimer disease, solanezumab does not slow cognitive decline, according to a study published online July 17 in theNew England Journal of Medicine&

Updated on:April 02,2024

Chaperone protein imbalance promotes toxic tau buildup in the aging brain

by University of South FloridaTau pathology resembling that seen in Alzheimer's disease brains. Credit: Laura Blair's laboratory, USF Health/University of South FloridaChaperone protein i

Updated on: April 25,2024

Chaperone protein imbalance promotes toxic tau buildup in the aging brain

by University of South FloridaTau pathology resembling that seen in Alzheimer's disease brains. Credit: Laura Blair's laboratory, USF Health/University of South FloridaChaperone protein i

Updated on:April 25,2024

Altered brain morphology and functional connectivity in postmenopausal women

by Impact Journals LLCBetween-group comparison map (premenopausal women vs. postmenopausal women) of the left mOFC functional connectivity. Credit:Aging(2024). DOI: 10.18632/aging.205662A

Updated on: April 06,2024

Altered brain morphology and functional connectivity in postmenopausal women

by Impact Journals LLCBetween-group comparison map (premenopausal women vs. postmenopausal women) of the left mOFC functional connectivity. Credit:Aging(2024). DOI: 10.18632/aging.205662A

Updated on:April 06,2024

Dementia metaphors help describe the condition, but can also perpetuate stigma and hinder treatment

by Jasmine Mah and Kaitlin Sibbald,The ConversationCredit: AI-generated imageHalf a million Canadians are living with dementiaandone in five Canadians has cared for someone with deme

Updated on: May 06,2024

Dementia metaphors help describe the condition, but can also perpetuate stigma and hinder treatment

by Jasmine Mah and Kaitlin Sibbald,The ConversationCredit: AI-generated imageHalf a million Canadians are living with dementiaandone in five Canadians has cared for someone with deme

Updated on:May 06,2024

Depression best treated by nonpharmacological approaches in people living with dementia

by University of New South WalesCredit: Pixabay/CC0 Public DomainResearch led by UNSW Sydney's Center for Healthy Brain Aging (CHeBA) has confirmed treating symptoms of depression is most eff

Updated on: May 06,2024

Depression best treated by nonpharmacological approaches in people living with dementia

by University of New South WalesCredit: Pixabay/CC0 Public DomainResearch led by UNSW Sydney's Center for Healthy Brain Aging (CHeBA) has confirmed treating symptoms of depression is most eff

Updated on:May 06,2024

Clinical trial results for lecanemab are a significant step for Alzheimer's, but not a historic breakthrough

by University of New South WalesAmyloid plaques and neurofibrillary tangles occur in the brains of patients with Alzheimer's disease. Credit: Ian JosonPartner companies Eisai and Biogen recen

Updated on: March 30,2024

Clinical trial results for lecanemab are a significant step for Alzheimer's, but not a historic breakthrough

by University of New South WalesAmyloid plaques and neurofibrillary tangles occur in the brains of patients with Alzheimer's disease. Credit: Ian JosonPartner companies Eisai and Biogen recen

Updated on:March 30,2024

MRI method purported to detect neurons' rapid impulses produces its own misleading signals instead

by McGovern Institute for Brain ResearchCredit: Pixabay/CC0 Public DomainA new way of imaging the brain with magnetic resonance imaging (MRI) does not directly detect neural activity as originally rep

Updated on: March 30,2024

MRI method purported to detect neurons' rapid impulses produces its own misleading signals instead

by McGovern Institute for Brain ResearchCredit: Pixabay/CC0 Public DomainA new way of imaging the brain with magnetic resonance imaging (MRI) does not directly detect neural activity as originally rep

Updated on:March 30,2024

Neural activity study shows the brain processes direct speech and its echo separately

byPublic Library of ScienceSpeech processing in an echoic environment. Credit: Jiaxin Gao (CC-BY 4.0, creativecommons.org/licenses/by/4.0/)Echoes can make speech harder to understand, and tuning

Updated on: March 13,2024

Neural activity study shows the brain processes direct speech and its echo separately

byPublic Library of ScienceSpeech processing in an echoic environment. Credit: Jiaxin Gao (CC-BY 4.0, creativecommons.org/licenses/by/4.0/)Echoes can make speech harder to understand, and tuning

Updated on:March 13,2024