Researchers discover new molecular drug targets for progressive neurological disorder

by Lynda De Widt,Mayo ClinicSingle-nucleus RNAseq captures glial expression changes in PSP brains. a Nuclei in UMAP space colored by cluster number and grouped by its cell type. b Average expres

Updated on: January 10,2024

Researchers discover new molecular drug targets for progressive neurological disorder

by Lynda De Widt,Mayo ClinicSingle-nucleus RNAseq captures glial expression changes in PSP brains. a Nuclei in UMAP space colored by cluster number and grouped by its cell type. b Average expres

Updated on:January 10,2024

Bench-to-bedside drug design could lead to new Alzheimer's disease treatments

by University of GlasgowCredit: CC0 Public DomainAn international team of scientists and pharmaceutical collaborators has made a breakthrough "bench to bedside" discovery, ten years in

Updated on: May 13,2024

Bench-to-bedside drug design could lead to new Alzheimer's disease treatments

by University of GlasgowCredit: CC0 Public DomainAn international team of scientists and pharmaceutical collaborators has made a breakthrough "bench to bedside" discovery, ten years in

Updated on:May 13,2024

Erectile dysfunction drugs may be linked to reduced risk of Alzheimer's disease

by American Academy of NeurologyCredit: CC0 Public DomainThe drugs used to treat erectile dysfunction may also be associated with a reduced risk of Alzheimer's disease, according to a study p

Updated on: June 01,2024

Erectile dysfunction drugs may be linked to reduced risk of Alzheimer's disease

by American Academy of NeurologyCredit: CC0 Public DomainThe drugs used to treat erectile dysfunction may also be associated with a reduced risk of Alzheimer's disease, according to a study p

Updated on:June 01,2024

ALS and dementia attacked by an RNA-hunting compound that recruits cell's own virus fighter

by The Scripps Research InstituteTo study the effectiveness of their compounds, the scientists directed cells from patients with ALS to become stem cells and then specialize into nerve cells. Cre

Updated on: June 14,2024

ALS and dementia attacked by an RNA-hunting compound that recruits cell's own virus fighter

by The Scripps Research InstituteTo study the effectiveness of their compounds, the scientists directed cells from patients with ALS to become stem cells and then specialize into nerve cells. Cre

Updated on:June 14,2024

Cancer chemotherapy drug reverses Alzheimer's symptoms in mice

by University of British ColumbiaCredit: Pixabay/CC0 Public DomainA drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's d

Updated on: April 25,2024

Cancer chemotherapy drug reverses Alzheimer's symptoms in mice

by University of British ColumbiaCredit: Pixabay/CC0 Public DomainA drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's d

Updated on:April 25,2024

Aging reduces the ability of regulatory T cells to enhance myelin regeneration, study finds

byMiguel Hernandez University of ElcheA Diagram explaining the experimental design of in vivo Treg depletion, Treg adoptive transfer and spinal cord demyelination. Representative images of immun

Updated on: March 28,2024

Aging reduces the ability of regulatory T cells to enhance myelin regeneration, study finds

byMiguel Hernandez University of ElcheA Diagram explaining the experimental design of in vivo Treg depletion, Treg adoptive transfer and spinal cord demyelination. Representative images of immun

Updated on:March 28,2024

Improved cellular recycling could benefit patients with neurodegenerative conditions

byThe Hospital for Sick ChildrenNon-functioning parts of the cell like damaged peroxisomes (pictured in yellow) are not recycled properly. On the right is an image from the Kim-Bandsma lab showi

Updated on: April 18,2024

Improved cellular recycling could benefit patients with neurodegenerative conditions

byThe Hospital for Sick ChildrenNon-functioning parts of the cell like damaged peroxisomes (pictured in yellow) are not recycled properly. On the right is an image from the Kim-Bandsma lab showi

Updated on:April 18,2024

Eli Lilly hopeful of Alzheimer's drug approval after promising results

Credit: Unsplash/CC0 Public DomainA second Alzheimer's drug proven to slow cognitive decline was a step closer to US approval on Monday after clinical trial results published in a top journal conf

Updated on: March 09,2024

Eli Lilly hopeful of Alzheimer's drug approval after promising results

Credit: Unsplash/CC0 Public DomainA second Alzheimer's drug proven to slow cognitive decline was a step closer to US approval on Monday after clinical trial results published in a top journal conf

Updated on:March 09,2024

How to boost your brain health

byRush University Medical CenterCredit: Kampus Production from PexelsCan simple diet and lifestyle changes keep your brain healthy? Do you have the power to prevent Alzheimer's disease and d

Updated on: February 05,2025

How to boost your brain health

byRush University Medical CenterCredit: Kampus Production from PexelsCan simple diet and lifestyle changes keep your brain healthy? Do you have the power to prevent Alzheimer's disease and d

Updated on:February 05,2025

Epigenetics blood markers can help understand dementia risk

byUniversity of ExeterOverview of the model generation. The model generation workflow consists of model training in the EXTEND and EMIF-AD cohorts using two different approaches. Credit:Al

Updated on: September 03,2024

Epigenetics blood markers can help understand dementia risk

byUniversity of ExeterOverview of the model generation. The model generation workflow consists of model training in the EXTEND and EMIF-AD cohorts using two different approaches. Credit:Al

Updated on:September 03,2024

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on: January 11,2024

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on:January 11,2024

Cooperation advances Alzheimer's disease prevention research

by GYMRThe future success of Alzheimer's prevention research could depend on the ability of researchers from different clinical trials to build collaborative relationships that facilitate the shar

Updated on: February 26,2024

Cooperation advances Alzheimer's disease prevention research

by GYMRThe future success of Alzheimer's prevention research could depend on the ability of researchers from different clinical trials to build collaborative relationships that facilitate the shar

Updated on:February 26,2024