First 'gene silencing' drug for Alzheimer's disease shows promise

by University College LondonEffect of MAPTRxon CSF concentrations of p-tau protein and tau/Aβ42. a, The mean percentage change from baseline in p-tau over time according to dose group. b, T

Updated on: March 30,2024

First 'gene silencing' drug for Alzheimer's disease shows promise

by University College LondonEffect of MAPTRxon CSF concentrations of p-tau protein and tau/Aβ42. a, The mean percentage change from baseline in p-tau over time according to dose group. b, T

Updated on:March 30,2024

Exploring how astrocytes respond to spinal cord injury or stroke-induced tissue damage

by Ingrid Fadelli , Medical XpressWound repair astrocytes (in green) form a border around the inflammatory cells (in white) that invade an area of brain tissue damaged by a small stroke. This astrocyt

Updated on: July 31,2024

Exploring how astrocytes respond to spinal cord injury or stroke-induced tissue damage

by Ingrid Fadelli , Medical XpressWound repair astrocytes (in green) form a border around the inflammatory cells (in white) that invade an area of brain tissue damaged by a small stroke. This astrocyt

Updated on:July 31,2024

New proteins involved in spinocerebellar ataxia provide insight into selective neuronal vulnerability

by Molly Chiu,Baylor College of MedicineGraphical abstract. Credit:Neuron(2022). DOI: 10.1016/j.neuron.2022.11.016Neurodegenerative disorders like Alzheimer's and Parkinson's

Updated on: February 05,2024

New proteins involved in spinocerebellar ataxia provide insight into selective neuronal vulnerability

by Molly Chiu,Baylor College of MedicineGraphical abstract. Credit:Neuron(2022). DOI: 10.1016/j.neuron.2022.11.016Neurodegenerative disorders like Alzheimer's and Parkinson's

Updated on:February 05,2024

The brain pulsates differently in people suffering from Alzheimer's disease

by University of OuluIn the magnetic resonance image, a healthy brain is higher and a lower one with Alzheimer's disease. Pulsations in the brain appear as red signals at the frequency of the hear

Updated on: April 20,2024

The brain pulsates differently in people suffering from Alzheimer's disease

by University of OuluIn the magnetic resonance image, a healthy brain is higher and a lower one with Alzheimer's disease. Pulsations in the brain appear as red signals at the frequency of the hear

Updated on:April 20,2024

Extra-large synapses could be a cause of schizophrenia

by RIKENExtra-strong synapses could play an important role in psychiatric disorders such as schizophrenia, a study by RIKEN researchers finds. Credit: Equinox Graphics/Science Photo LibrarySchizo

Updated on: February 03,2024

Extra-large synapses could be a cause of schizophrenia

by RIKENExtra-strong synapses could play an important role in psychiatric disorders such as schizophrenia, a study by RIKEN researchers finds. Credit: Equinox Graphics/Science Photo LibrarySchizo

Updated on:February 03,2024

A new breakthrough in Alzheimer's disease research: Visualizing reactive astrocyte-neuron interaction

by Institute for Basic ScienceFig. 1. Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acet

Updated on: April 16,2024

A new breakthrough in Alzheimer's disease research: Visualizing reactive astrocyte-neuron interaction

by Institute for Basic ScienceFig. 1. Augmentation of acetate uptake, mediated by MCT1, facilitates Aβ-induced GABA release in reactive astrocyte. A. Blockade effect of MCT1 inhibitor on 14C-acet

Updated on:April 16,2024

Dementia found to be the dominant risk factor for COVID in elderly care

by University of GothenburgHazard ratios (HR) and 95% Confidence intervals (CI) of the relationship between individual-level factors (age, sex, education, dementia, cardiovascular disease, lung d

Updated on: May 06,2024

Dementia found to be the dominant risk factor for COVID in elderly care

by University of GothenburgHazard ratios (HR) and 95% Confidence intervals (CI) of the relationship between individual-level factors (age, sex, education, dementia, cardiovascular disease, lung d

Updated on:May 06,2024

Successful Phase 2 clinical trial for neflamapimod in mild-to-moderate Lewy body dementia

by University of North Carolina at Chapel Hill School of MedicineCredit: CC0 Public DomainEIP Pharma announced on October 6 that a phase 2 study in patients with mild-to-moderate Lewy body dement

Updated on: April 01,2024

Successful Phase 2 clinical trial for neflamapimod in mild-to-moderate Lewy body dementia

by University of North Carolina at Chapel Hill School of MedicineCredit: CC0 Public DomainEIP Pharma announced on October 6 that a phase 2 study in patients with mild-to-moderate Lewy body dement

Updated on:April 01,2024

Understanding the genetic roots of rare mutations in Alzheimer's disease

byVIB (the Flanders Institute for Biotechnology)Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow). When the PSEN2 gene is absent or carries a familial

Updated on: December 11,2024

Understanding the genetic roots of rare mutations in Alzheimer's disease

byVIB (the Flanders Institute for Biotechnology)Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow). When the PSEN2 gene is absent or carries a familial

Updated on:December 11,2024

Molecular alterations in neuronal trophic regulation in Alzheimer's pathology

by Jason Clement,McGill UniversityCredit: Unsplash/CC0 Public DomainFor decades researchers have known that Alzheimer's disease (AD) causes the atrophy of a system of neurons and synapses hi

Updated on: April 02,2024

Molecular alterations in neuronal trophic regulation in Alzheimer's pathology

by Jason Clement,McGill UniversityCredit: Unsplash/CC0 Public DomainFor decades researchers have known that Alzheimer's disease (AD) causes the atrophy of a system of neurons and synapses hi

Updated on:April 02,2024

How invisible presences hijack the social counting brain in Parkinson's disease

by Ecole Polytechnique Federale de LausanneCredit: Pixabay/CC0 Public DomainIf you had to estimate the number of people in a room, without counting them one by one, by nature you would overcount

Updated on: March 19,2024

How invisible presences hijack the social counting brain in Parkinson's disease

by Ecole Polytechnique Federale de LausanneCredit: Pixabay/CC0 Public DomainIf you had to estimate the number of people in a room, without counting them one by one, by nature you would overcount

Updated on:March 19,2024

Depression best treated by nonpharmacological approaches in people living with dementia

by University of New South WalesCredit: Pixabay/CC0 Public DomainResearch led by UNSW Sydney's Center for Healthy Brain Aging (CHeBA) has confirmed treating symptoms of depression is most eff

Updated on: May 06,2024

Depression best treated by nonpharmacological approaches in people living with dementia

by University of New South WalesCredit: Pixabay/CC0 Public DomainResearch led by UNSW Sydney's Center for Healthy Brain Aging (CHeBA) has confirmed treating symptoms of depression is most eff

Updated on:May 06,2024