New proteins involved in spinocerebellar ataxia provide insight into selective neuronal vulnerability

by Molly Chiu,Baylor College of MedicineGraphical abstract. Credit:Neuron(2022). DOI: 10.1016/j.neuron.2022.11.016Neurodegenerative disorders like Alzheimer's and Parkinson's

Updated on: February 05,2024

New proteins involved in spinocerebellar ataxia provide insight into selective neuronal vulnerability

by Molly Chiu,Baylor College of MedicineGraphical abstract. Credit:Neuron(2022). DOI: 10.1016/j.neuron.2022.11.016Neurodegenerative disorders like Alzheimer's and Parkinson's

Updated on:February 05,2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets

by Ari Navetta,Broad Institute of MIT and HarvardEpilepsy genetic architecture from large-scale genetic association studies. Credit:Nature Neuroscience(2024). DOI: 10.1038/s41593-024

Updated on: October 09,2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets

by Ari Navetta,Broad Institute of MIT and HarvardEpilepsy genetic architecture from large-scale genetic association studies. Credit:Nature Neuroscience(2024). DOI: 10.1038/s41593-024

Updated on:October 09,2024

How gut neurons communicate with the brain to control thirst

by Lori Dajose,California Institute of TechnologyFig. 1: The vagus nerve responds to visceral osmolality changes. Credit: DOI: 10.1038/s41586-021-04359-5Drinking a glass of water is often suffic

Updated on: February 05,2024

How gut neurons communicate with the brain to control thirst

by Lori Dajose,California Institute of TechnologyFig. 1: The vagus nerve responds to visceral osmolality changes. Credit: DOI: 10.1038/s41586-021-04359-5Drinking a glass of water is often suffic

Updated on:February 05,2024

Microscopic blood vessel disease in the brain's white matter associated with worse cognition in Alzheimer's

by Medical College of Georgia at Augusta UniversityDr. Zsolt Bagi with coauthors Katie Anne Fopiano, AU graduate student, and Dr. Yanna Tian, who just earned her graduate degree from AU and has s

Updated on: April 20,2024

Microscopic blood vessel disease in the brain's white matter associated with worse cognition in Alzheimer's

by Medical College of Georgia at Augusta UniversityDr. Zsolt Bagi with coauthors Katie Anne Fopiano, AU graduate student, and Dr. Yanna Tian, who just earned her graduate degree from AU and has s

Updated on:April 20,2024

New alteration in the brains of people with Alzheimer's discovered

by Spanish National Research Council (CSIC)Credit: Unsplash/CC0 Public DomainDespite the important advances in research in recent years, the etiopathogenesis of Alzheimer's disease is still not fu

Updated on: April 20,2024

New alteration in the brains of people with Alzheimer's discovered

by Spanish National Research Council (CSIC)Credit: Unsplash/CC0 Public DomainDespite the important advances in research in recent years, the etiopathogenesis of Alzheimer's disease is still not fu

Updated on:April 20,2024

Connections between addictive drugs and brain function in mice

by John Spizzirri,Argonne National LaboratoryFigure 1. Experimental design for dopamine connectomics. (A) Adeno-associated viruses (AAVs) expressing Cre-dependent Apex2 were bilaterally injected

Updated on: February 05,2024

Connections between addictive drugs and brain function in mice

by John Spizzirri,Argonne National LaboratoryFigure 1. Experimental design for dopamine connectomics. (A) Adeno-associated viruses (AAVs) expressing Cre-dependent Apex2 were bilaterally injected

Updated on:February 05,2024

Researchers find some evidence of link between stress, Alzheimer's disease

by University of FloridaTodd Golde, M.D., Ph.D., director of the UF Center for Translational Research in Neurodegenerative Disease and a professor in the UF College of Medicine's department o

Updated on: February 26,2024

Researchers find some evidence of link between stress, Alzheimer's disease

by University of FloridaTodd Golde, M.D., Ph.D., director of the UF Center for Translational Research in Neurodegenerative Disease and a professor in the UF College of Medicine's department o

Updated on:February 26,2024

Alzheimer's leads to changes in the small blood vessels in the brain

by University of OsloEarlier research has shown that several of the same risk factors behind the development of cardiovascular disease also can lead to Alzheimer’s. Pictured left to right: Shreya

Updated on: April 25,2024

Alzheimer's leads to changes in the small blood vessels in the brain

by University of OsloEarlier research has shown that several of the same risk factors behind the development of cardiovascular disease also can lead to Alzheimer’s. Pictured left to right: Shreya

Updated on:April 25,2024

New insights into the molecular mechanisms behind the action of secretagogin

byKarolinska InstitutetThe vesicular release of neurotransmitters and hormones relies on the SNARE-complex formed by three proteins: VAMP (blue), Syntaxin (pink) and SNAP-25 (green). Secretagoin

Updated on: April 28,2024

New insights into the molecular mechanisms behind the action of secretagogin

byKarolinska InstitutetThe vesicular release of neurotransmitters and hormones relies on the SNARE-complex formed by three proteins: VAMP (blue), Syntaxin (pink) and SNAP-25 (green). Secretagoin

Updated on:April 28,2024

Dementia found to be the dominant risk factor for COVID in elderly care

by University of GothenburgHazard ratios (HR) and 95% Confidence intervals (CI) of the relationship between individual-level factors (age, sex, education, dementia, cardiovascular disease, lung d

Updated on: May 06,2024

Dementia found to be the dominant risk factor for COVID in elderly care

by University of GothenburgHazard ratios (HR) and 95% Confidence intervals (CI) of the relationship between individual-level factors (age, sex, education, dementia, cardiovascular disease, lung d

Updated on:May 06,2024

First 'gene silencing' drug for Alzheimer's disease shows promise

by University College LondonEffect of MAPTRxon CSF concentrations of p-tau protein and tau/Aβ42. a, The mean percentage change from baseline in p-tau over time according to dose group. b, T

Updated on: March 30,2024

First 'gene silencing' drug for Alzheimer's disease shows promise

by University College LondonEffect of MAPTRxon CSF concentrations of p-tau protein and tau/Aβ42. a, The mean percentage change from baseline in p-tau over time according to dose group. b, T

Updated on:March 30,2024

Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders

by University of California, IrvineA projection of CRH/GABA neurons in the medial BLA to the medial NAc shell.a–cRetrograde tracing of CRH+neuronal inputs to medial NAc shell of

Updated on: March 26,2024

Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders

by University of California, IrvineA projection of CRH/GABA neurons in the medial BLA to the medial NAc shell.a–cRetrograde tracing of CRH+neuronal inputs to medial NAc shell of

Updated on:March 26,2024