New drug targets for Alzheimer's identified from cerebrospinal fluid

by Mark Reynolds,Washington University School of MedicineCellular localization of immune and lysosomal proteins. Credit:Nature Genetics(2024). DOI: 10.1038/s41588-024-01972-8A multit

Updated on: November 22,2024

New drug targets for Alzheimer's identified from cerebrospinal fluid

by Mark Reynolds,Washington University School of MedicineCellular localization of immune and lysosomal proteins. Credit:Nature Genetics(2024). DOI: 10.1038/s41588-024-01972-8A multit

Updated on:November 22,2024

Forty percent of dementia cases could be prevented or delayed by targeting 12 risk factors throughout life

by LancetCredit: CC0 Public DomainModifying 12 risk factors over the lifecourse could delay or prevent 40% of dementia cases, according to an update toThe LancetCommission on dementia

Updated on: March 13,2024

Forty percent of dementia cases could be prevented or delayed by targeting 12 risk factors throughout life

by LancetCredit: CC0 Public DomainModifying 12 risk factors over the lifecourse could delay or prevent 40% of dementia cases, according to an update toThe LancetCommission on dementia

Updated on:March 13,2024

New tool provides researchers with improved understanding of stem cell aging in the brain

by University of Wisconsin-MadisonPatterns in the tiny amounts of light emitted by these neural stem cells helped researchers determine whether they were active or dormant without destructive tes

Updated on: March 30,2024

New tool provides researchers with improved understanding of stem cell aging in the brain

by University of Wisconsin-MadisonPatterns in the tiny amounts of light emitted by these neural stem cells helped researchers determine whether they were active or dormant without destructive tes

Updated on:March 30,2024

CRISPR helps identify potential Alzheimer's-related protein

by University of TokyoCredit: CC0 Public DomainExperts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "mo

Updated on: March 30,2024

CRISPR helps identify potential Alzheimer's-related protein

by University of TokyoCredit: CC0 Public DomainExperts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "mo

Updated on:March 30,2024

Alzheimer's drug trial targets toxic proteases from gum disease bacteria in the brain

by Alzheimer's Research UKP. gingivalis colonies grown on blood agar. CC0 Public DomainThe pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer's drug that

Updated on: April 16,2024

Alzheimer's drug trial targets toxic proteases from gum disease bacteria in the brain

by Alzheimer's Research UKP. gingivalis colonies grown on blood agar. CC0 Public DomainThe pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer's drug that

Updated on:April 16,2024

MS changes the microbiome subtly but similarly, whether in US or Asia

by Kim Krieger,University of ConnecticutDisruption of Bacteroides-Prevotella correlative network in MS. a, b Correlations shared between MS and controls. c Correlations that are unique in contro

Updated on: August 08,2024

MS changes the microbiome subtly but similarly, whether in US or Asia

by Kim Krieger,University of ConnecticutDisruption of Bacteroides-Prevotella correlative network in MS. a, b Correlations shared between MS and controls. c Correlations that are unique in contro

Updated on:August 08,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on: March 02,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on:March 02,2024

Scientists isolate genes that delay Alzheimer's

by Australian National UniversityAssociate Professor Arcos-Burgos (centre) with Dr Claudio Mastronardi and Dr Hardip Patel. Credit: Stuart Hay, ANUScientists have identified a network of nine gen

Updated on: February 27,2024

Scientists isolate genes that delay Alzheimer's

by Australian National UniversityAssociate Professor Arcos-Burgos (centre) with Dr Claudio Mastronardi and Dr Hardip Patel. Credit: Stuart Hay, ANUScientists have identified a network of nine gen

Updated on:February 27,2024

Insulin resistance may lead to faster cognitive decline

by Tel Aviv UniversityCredit: Tel Aviv UniversityA new Tel Aviv University study published in theJournal of Alzheimer's Diseasefinds that insulin resistance, caused in part by obe

Updated on: March 09,2024

Insulin resistance may lead to faster cognitive decline

by Tel Aviv UniversityCredit: Tel Aviv UniversityA new Tel Aviv University study published in theJournal of Alzheimer's Diseasefinds that insulin resistance, caused in part by obe

Updated on:March 09,2024

Drop in mortality seen with AChEI, memantine in dementia with lewy bodies

by Elana GotkineFor patients with dementia with Lewy bodies (DLB), treatment with acetylcholinesterase inhibitors (AChEIs) and/or memantine is associated with reduced hospital admissions and mortality

Updated on: June 24,2024

Drop in mortality seen with AChEI, memantine in dementia with lewy bodies

by Elana GotkineFor patients with dementia with Lewy bodies (DLB), treatment with acetylcholinesterase inhibitors (AChEIs) and/or memantine is associated with reduced hospital admissions and mortality

Updated on:June 24,2024

Dementia researchers call for urgent action to prevent setbacks in treatment search

by Alzheimer's Research UKCredit: CC0 Public DomainNearly 300 researchers have called for urgent government action to prevent a major setback to the search for new dementia treatments as a re

Updated on: May 11,2024

Dementia researchers call for urgent action to prevent setbacks in treatment search

by Alzheimer's Research UKCredit: CC0 Public DomainNearly 300 researchers have called for urgent government action to prevent a major setback to the search for new dementia treatments as a re

Updated on:May 11,2024

Mitochondrial roles in antiviral immunity modify manifestations of neurological diseases

by University of HelsinkiSchematic of antiviral innate immune signaling responses to viral PAMPs. Credit:Nature(2024). DOI: 10.1038/s41586-024-07260-zA multidisciplinary team of scien

Updated on: April 06,2024

Mitochondrial roles in antiviral immunity modify manifestations of neurological diseases

by University of HelsinkiSchematic of antiviral innate immune signaling responses to viral PAMPs. Credit:Nature(2024). DOI: 10.1038/s41586-024-07260-zA multidisciplinary team of scien

Updated on:April 06,2024