Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on: July 01,2024

Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on:July 01,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on: March 02,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on:March 02,2024

Autophagy malfunction study moves a step closer to understanding Rett syndrome

Updated on: April 17,2025

Autophagy malfunction study moves a step closer to understanding Rett syndrome

Updated on:April 17,2025

Novel method facilitates study of oxidized lipids involved in neurodegenerative diseases

NOVEMBER 15, 2023byFAPESPGraphical abstract. Credit:Free Radical Biology and Medicine(2023). DOI: 10.1016/j.freeradbiomed.2023.08.019Lipids are a diversified class of biomolecules wi

Updated on: March 28,2024

Novel method facilitates study of oxidized lipids involved in neurodegenerative diseases

NOVEMBER 15, 2023byFAPESPGraphical abstract. Credit:Free Radical Biology and Medicine(2023). DOI: 10.1016/j.freeradbiomed.2023.08.019Lipids are a diversified class of biomolecules wi

Updated on:March 28,2024

Alzheimer's risk gene impairs development of new neurons in mice

by Society for NeuroscienceApoE-expressing astrocytes (green) interacting with tdTomato-expressing dendrites (red) from adult newborn hippocampal neurons. Credit: Tensaouti et al.,eNeuro&nb

Updated on: April 20,2024

Alzheimer's risk gene impairs development of new neurons in mice

by Society for NeuroscienceApoE-expressing astrocytes (green) interacting with tdTomato-expressing dendrites (red) from adult newborn hippocampal neurons. Credit: Tensaouti et al.,eNeuro&nb

Updated on:April 20,2024

COVID-19 infection in crucial brain regions may lead to accelerated brain aging

by Houston MethodistThe interaction of SARS-CoV-2 with olfactory cilia for entering the central nervous system (CNS). A) Different layers of cells in the nasal cavity that contain receptors for t

Updated on: February 21,2024

COVID-19 infection in crucial brain regions may lead to accelerated brain aging

by Houston MethodistThe interaction of SARS-CoV-2 with olfactory cilia for entering the central nervous system (CNS). A) Different layers of cells in the nasal cavity that contain receptors for t

Updated on:February 21,2024

Yeast protein could offer clues to how Alzheimer's plaques form in the brain

by Anne Trafton,Massachusetts Institute of TechnologyMIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s dise

Updated on: February 26,2024

Yeast protein could offer clues to how Alzheimer's plaques form in the brain

by Anne Trafton,Massachusetts Institute of TechnologyMIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s dise

Updated on:February 26,2024

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on: April 16,2024

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on:April 16,2024

New imaging technique in Alzheimer's disease opens up possibilities for drug development

by Lund UniversityThe brain of an Alzheimer’s patient in a tau PET image. Red indicates the areas with the highest concentration of the tau protein. In the magnifying glass, a microscope enlargem

Updated on: April 07,2024

New imaging technique in Alzheimer's disease opens up possibilities for drug development

by Lund UniversityThe brain of an Alzheimer’s patient in a tau PET image. Red indicates the areas with the highest concentration of the tau protein. In the magnifying glass, a microscope enlargem

Updated on:April 07,2024

AEDs tied to higher pneumonia risk in Alzheimer patients

(HealthDay)—Antiepileptic drug (AED) use may increase the risk for pneumonia in patients with Alzheimer disease (AD), according to a study recently published in theJournal of Alzheimer's Dis

Updated on: March 19,2024

AEDs tied to higher pneumonia risk in Alzheimer patients

(HealthDay)—Antiepileptic drug (AED) use may increase the risk for pneumonia in patients with Alzheimer disease (AD), according to a study recently published in theJournal of Alzheimer's Dis

Updated on:March 19,2024

Swedish diagnostic method for Alzheimer's becomes international standard

by Krister Svahn,University of GothenburgResearchers at Gothenburg University have developed a reference method for standardized measurements that diagnose Alzheimer's disease decades before

Updated on: February 26,2024

Swedish diagnostic method for Alzheimer's becomes international standard

by Krister Svahn,University of GothenburgResearchers at Gothenburg University have developed a reference method for standardized measurements that diagnose Alzheimer's disease decades before

Updated on:February 26,2024

A healthy lifestyle almost halves the risk of dementia in people with type 2 diabetes

by DiabetologiaCredit: Unsplash/CC0 Public DomainA healthy lifestyle reduces the risk of dementia in those with type 2 diabetes (T2D), according to a study of hundreds of thousands of people in t

Updated on: June 24,2024

A healthy lifestyle almost halves the risk of dementia in people with type 2 diabetes

by DiabetologiaCredit: Unsplash/CC0 Public DomainA healthy lifestyle reduces the risk of dementia in those with type 2 diabetes (T2D), according to a study of hundreds of thousands of people in t

Updated on:June 24,2024