Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on: July 01,2024

Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on:July 01,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on: March 02,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on:March 02,2024

Novel method facilitates study of oxidized lipids involved in neurodegenerative diseases

NOVEMBER 15, 2023byFAPESPGraphical abstract. Credit:Free Radical Biology and Medicine(2023). DOI: 10.1016/j.freeradbiomed.2023.08.019Lipids are a diversified class of biomolecules wi

Updated on: March 28,2024

Novel method facilitates study of oxidized lipids involved in neurodegenerative diseases

NOVEMBER 15, 2023byFAPESPGraphical abstract. Credit:Free Radical Biology and Medicine(2023). DOI: 10.1016/j.freeradbiomed.2023.08.019Lipids are a diversified class of biomolecules wi

Updated on:March 28,2024

Alzheimer's risk gene impairs development of new neurons in mice

by Society for NeuroscienceApoE-expressing astrocytes (green) interacting with tdTomato-expressing dendrites (red) from adult newborn hippocampal neurons. Credit: Tensaouti et al.,eNeuro&nb

Updated on: April 20,2024

Alzheimer's risk gene impairs development of new neurons in mice

by Society for NeuroscienceApoE-expressing astrocytes (green) interacting with tdTomato-expressing dendrites (red) from adult newborn hippocampal neurons. Credit: Tensaouti et al.,eNeuro&nb

Updated on:April 20,2024

Cutting-edge treatment approach addresses neurobehavioral symptoms in neurofibromatosis type 1

Updated on: August 07,2025

Cutting-edge treatment approach addresses neurobehavioral symptoms in neurofibromatosis type 1

Updated on:August 07,2025

COVID-19 infection in crucial brain regions may lead to accelerated brain aging

by Houston MethodistThe interaction of SARS-CoV-2 with olfactory cilia for entering the central nervous system (CNS). A) Different layers of cells in the nasal cavity that contain receptors for t

Updated on: February 21,2024

COVID-19 infection in crucial brain regions may lead to accelerated brain aging

by Houston MethodistThe interaction of SARS-CoV-2 with olfactory cilia for entering the central nervous system (CNS). A) Different layers of cells in the nasal cavity that contain receptors for t

Updated on:February 21,2024

Alzheimer's disease and type 2 diabetes—hope for inhibitors against amyloid plaques

by Technical University MunichA new class of designed macrocyclic peptides has been developed which are highly potent inhibitors of amyloid plaque formation. Credit: Kapurniotu/ TUMEffective ther

Updated on: April 08,2024

Alzheimer's disease and type 2 diabetes—hope for inhibitors against amyloid plaques

by Technical University MunichA new class of designed macrocyclic peptides has been developed which are highly potent inhibitors of amyloid plaque formation. Credit: Kapurniotu/ TUMEffective ther

Updated on:April 08,2024

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on: April 16,2024

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on:April 16,2024

Yeast protein could offer clues to how Alzheimer's plaques form in the brain

by Anne Trafton,Massachusetts Institute of TechnologyMIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s dise

Updated on: February 26,2024

Yeast protein could offer clues to how Alzheimer's plaques form in the brain

by Anne Trafton,Massachusetts Institute of TechnologyMIT biologists found that the yeast protein Rim4 forms disordered clumps similar to the beta-amyloid plaques associated with Alzheimer’s dise

Updated on:February 26,2024

Human brains are getting larger: That may be good news for dementia risk

byUC DavisHuman brain volume has increased for people born in the 1970s compared to the 1930s. Credit: UC Davis HealthA new study by researchers at UC Davis Health found human brains are getting

Updated on: March 28,2024

Human brains are getting larger: That may be good news for dementia risk

byUC DavisHuman brain volume has increased for people born in the 1970s compared to the 1930s. Credit: UC Davis HealthA new study by researchers at UC Davis Health found human brains are getting

Updated on:March 28,2024

Memory games: Eating well to remember

by University of Technology, SydneyCredit: CC0 Public DomainA healthy diet is essential to living well, but as we age, should we change what we eat?UTS research fellow Dr. Luna Xu has studied dat

Updated on: June 20,2024

Memory games: Eating well to remember

by University of Technology, SydneyCredit: CC0 Public DomainA healthy diet is essential to living well, but as we age, should we change what we eat?UTS research fellow Dr. Luna Xu has studied dat

Updated on:June 20,2024

Autophagy malfunction study moves a step closer to understanding Rett syndrome

Updated on: April 17,2025

Autophagy malfunction study moves a step closer to understanding Rett syndrome

Updated on:April 17,2025