New discovery could help treat a rare and severe form of amyloidosis

byWileyPET scan of a human brain with Alzheimer's disease. Credit: public domainIn people with a rare condition called light chain amyloidosis, light chain proteins—which are a component of

Updated on: July 11,2024

New discovery could help treat a rare and severe form of amyloidosis

byWileyPET scan of a human brain with Alzheimer's disease. Credit: public domainIn people with a rare condition called light chain amyloidosis, light chain proteins—which are a component of

Updated on:July 11,2024

How zebrafish map their environment: Spatial orientation mechanisms surprisingly similar to our own

by Sophia Jahns, Max Planck Institute for Biological CyberneticsIdentification of PCs in the larval zebrafish brain. Credit:Nature(2024). DOI: 10.1038/s41586-024-07867-2Researchers are tur

Updated on: September 06,2024

How zebrafish map their environment: Spatial orientation mechanisms surprisingly similar to our own

by Sophia Jahns, Max Planck Institute for Biological CyberneticsIdentification of PCs in the larval zebrafish brain. Credit:Nature(2024). DOI: 10.1038/s41586-024-07867-2Researchers are tur

Updated on:September 06,2024

Successful or pathological cognitive aging? The 'frontal preservation, temporal impairment (FPTI)' hypothesis

by Science China PressThe SCA group has specific frontal preservation and the MCI group has specific temporal impairment on GM morphology, GM network, and WM network properties, in addition, the

Updated on: February 05,2024

Successful or pathological cognitive aging? The 'frontal preservation, temporal impairment (FPTI)' hypothesis

by Science China PressThe SCA group has specific frontal preservation and the MCI group has specific temporal impairment on GM morphology, GM network, and WM network properties, in addition, the

Updated on:February 05,2024

New genetic risk marker for late-life depression

by ElsevierOne of the most powerful predictors in neuropsychiatry is the epsilon 4 (ε4) allele of the apolipoprotein gene (APOE).Individuals who carry this ε4 variant of APOE are at increased ris

Updated on: February 26,2024

New genetic risk marker for late-life depression

by ElsevierOne of the most powerful predictors in neuropsychiatry is the epsilon 4 (ε4) allele of the apolipoprotein gene (APOE).Individuals who carry this ε4 variant of APOE are at increased ris

Updated on:February 26,2024

Dementia: Catching the memory thief

by University of CambridgeCredit: CC0 Public DomainIt's over a hundred years since the first case of Alzheimer's disease was diagnosed. Since then we've learned a great deal about the

Updated on: May 11,2024

Dementia: Catching the memory thief

by University of CambridgeCredit: CC0 Public DomainIt's over a hundred years since the first case of Alzheimer's disease was diagnosed. Since then we've learned a great deal about the

Updated on:May 11,2024

Neuronal heparan sulfates play role in amyloid pathology

(HealthDay)—Neuronal heparan sulfates (HSs) modulate brain amyloid-β (Aβ) clearance and aggregation in a mouse model of Alzheimer's disease (AD), according to an experimental study published in th

Updated on: February 28,2024

Neuronal heparan sulfates play role in amyloid pathology

(HealthDay)—Neuronal heparan sulfates (HSs) modulate brain amyloid-β (Aβ) clearance and aggregation in a mouse model of Alzheimer's disease (AD), according to an experimental study published in th

Updated on:February 28,2024

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on: April 16,2024

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on:April 16,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on: March 07,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on:March 07,2024

Alzheimer's detected before symptoms via new eye technology

by Association for Research in Vision and OphthalmologyRockville, Md. Scientists may have overcome a major roadblock in the development of Alzheimer's therapies by creating a new technology t

Updated on: March 07,2024

Alzheimer's detected before symptoms via new eye technology

by Association for Research in Vision and OphthalmologyRockville, Md. Scientists may have overcome a major roadblock in the development of Alzheimer's therapies by creating a new technology t

Updated on:March 07,2024

Researchers identify the 'broken gate' causing unstoppable brain signals in severe childhood epilepsy

by Florey Institute of Neuroscience and Mental Health2D transmembrane topology of the wild-type (WT) Nav1.2 channel showing 27 domains DI−DIV and amino acid residues N1662 (cytosolic side of S5DIV) an

Updated on: August 03,2024

Researchers identify the 'broken gate' causing unstoppable brain signals in severe childhood epilepsy

by Florey Institute of Neuroscience and Mental Health2D transmembrane topology of the wild-type (WT) Nav1.2 channel showing 27 domains DI−DIV and amino acid residues N1662 (cytosolic side of S5DIV) an

Updated on:August 03,2024

People with dementia fail to get specialist care despite great need

by University College LondonCredit: University College LondonPeople suffering in the late stages of dementia receive most of their healthcare from GPs or emergency services rather than from speci

Updated on: May 08,2024

People with dementia fail to get specialist care despite great need

by University College LondonCredit: University College LondonPeople suffering in the late stages of dementia receive most of their healthcare from GPs or emergency services rather than from speci

Updated on:May 08,2024

Uncovering the molecular mechanism behind synapse loss in Alzheimer's disease

by Korea Brain Research InstituteCredit: Unsplash/CC0 Public DomainKorea Brain Research Institute (KBRI, Pann-Ghill Suh (President)) announced that Dr. Kea Joo Lee and Dr. You-Na Jang of the Neural Ci

Updated on: July 01,2024

Uncovering the molecular mechanism behind synapse loss in Alzheimer's disease

by Korea Brain Research InstituteCredit: Unsplash/CC0 Public DomainKorea Brain Research Institute (KBRI, Pann-Ghill Suh (President)) announced that Dr. Kea Joo Lee and Dr. You-Na Jang of the Neural Ci

Updated on:July 01,2024