Alzheimer's: New study supports amyloid hypothesis but suggests alternative treatment

by Columbia UniversityCREB3L2-ATF4 up-regulation in β-amyloid pathology 5xFAD model. In vivo detection and quantification of CREB3L2-ATF4 dimers by PLA in the dentate gyrus of 10-week-old 5xFAD o

Updated on: April 10,2024

Alzheimer's: New study supports amyloid hypothesis but suggests alternative treatment

by Columbia UniversityCREB3L2-ATF4 up-regulation in β-amyloid pathology 5xFAD model. In vivo detection and quantification of CREB3L2-ATF4 dimers by PLA in the dentate gyrus of 10-week-old 5xFAD o

Updated on:April 10,2024

Decoding sleep to reveal our state of health

by Bruno Geoffroy,University of MontrealA Schematic representation of the position of cannulas (in CA1) and electrodes (surface of the cerebral cortex) and timeline of the experimental protocol.

Updated on: March 28,2024

Decoding sleep to reveal our state of health

by Bruno Geoffroy,University of MontrealA Schematic representation of the position of cannulas (in CA1) and electrodes (surface of the cerebral cortex) and timeline of the experimental protocol.

Updated on:March 28,2024

How Alzheimer's disease spreads throughout the brain – new study

by Thomas E Cope,The ConversationHarmful tau protein spreads through networks.Alzheimer's disease is a devastating brain illness that affects anestimated 47m peopleworldwide. It

Updated on: April 10,2024

How Alzheimer's disease spreads throughout the brain – new study

by Thomas E Cope,The ConversationHarmful tau protein spreads through networks.Alzheimer's disease is a devastating brain illness that affects anestimated 47m peopleworldwide. It

Updated on:April 10,2024

P-glycoprotein removes Alzheimer's-associated toxin from the brain

by Southern Methodist University(A) The first frame of SMU's simulation shows amyloid-β bound to the drug binding domains of P-gp. (B) The final frame of the same simulation shows P-gp pushin

Updated on: April 01,2024

P-glycoprotein removes Alzheimer's-associated toxin from the brain

by Southern Methodist University(A) The first frame of SMU's simulation shows amyloid-β bound to the drug binding domains of P-gp. (B) The final frame of the same simulation shows P-gp pushin

Updated on:April 01,2024

Cardiometabolic diseases may influence both risk and progression of motor neuron diseases

Cardiometabolic diseases may influence both risk and progression of motor neuron diseasesbyKarolinska InstitutetCredit: PixabayA new study from the Institute of Environmental Medicine (IMM),&nbs

Updated on: January 15,2025

Cardiometabolic diseases may influence both risk and progression of motor neuron diseases

Cardiometabolic diseases may influence both risk and progression of motor neuron diseasesbyKarolinska InstitutetCredit: PixabayA new study from the Institute of Environmental Medicine (IMM),&nbs

Updated on:January 15,2025

Alzheimer's missing link ID'd, answering what tips brain's decline

by Washington University School of MedicineIn Alzheimer's, amyloid clumps (blue) develop first in the brain, followed by tangles of the protein tau (red). Tau is associated with memory loss a

Updated on: April 20,2024

Alzheimer's missing link ID'd, answering what tips brain's decline

by Washington University School of MedicineIn Alzheimer's, amyloid clumps (blue) develop first in the brain, followed by tangles of the protein tau (red). Tau is associated with memory loss a

Updated on:April 20,2024

Researchers discover mechanism by which estrogen can trigger fast neuronal responses

byBaylor College of MedicineCredit: Public DomainEstrogen, the major female ovarian hormone, can trigger nerve impulses within milliseconds to regulate a variety of physiological processes. At B

Updated on: October 14,2024

Researchers discover mechanism by which estrogen can trigger fast neuronal responses

byBaylor College of MedicineCredit: Public DomainEstrogen, the major female ovarian hormone, can trigger nerve impulses within milliseconds to regulate a variety of physiological processes. At B

Updated on:October 14,2024

Emergency/urgent hospitalizations linked to accelerated cognitive decline in older adults

by Rush University Medical CenterCredit: CC0 Public DomainEmergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers at R

Updated on: June 18,2024

Emergency/urgent hospitalizations linked to accelerated cognitive decline in older adults

by Rush University Medical CenterCredit: CC0 Public DomainEmergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers at R

Updated on:June 18,2024

Unraveling Alzheimer's catalysts as weavers of amyloid β fibrils

by National Institutes of Natural Sciences(A) On the neuronal cell membrane, Aβ molecules adopt a "U"-shaped conformation, allining alternately on the membrane surface to form two layer

Updated on: July 01,2024

Unraveling Alzheimer's catalysts as weavers of amyloid β fibrils

by National Institutes of Natural Sciences(A) On the neuronal cell membrane, Aβ molecules adopt a "U"-shaped conformation, allining alternately on the membrane surface to form two layer

Updated on:July 01,2024

Minimally invasive neural interface allows brain access without skull opening

byRice UniversityEndocisternal neural interface in human and sheep models. Credit:Nature Biomedical Engineering(2024). DOI: 10.1038/s41551-024-01281-9A team of researchers led by Ric

Updated on: November 28,2024

Minimally invasive neural interface allows brain access without skull opening

byRice UniversityEndocisternal neural interface in human and sheep models. Credit:Nature Biomedical Engineering(2024). DOI: 10.1038/s41551-024-01281-9A team of researchers led by Ric

Updated on:November 28,2024

Alzheimer's disease may cause vicious circle between brain network and immune cell dysfunctions

by Sarah C.p. Williams,Gladstone InstitutesA new study by Gladstone scientists suggests that certain anti-epileptic or tau-reducing treatments could be promising for people in the early stages o

Updated on: April 10,2024

Alzheimer's disease may cause vicious circle between brain network and immune cell dysfunctions

by Sarah C.p. Williams,Gladstone InstitutesA new study by Gladstone scientists suggests that certain anti-epileptic or tau-reducing treatments could be promising for people in the early stages o

Updated on:April 10,2024

Nearly one-third of patients with TBI have marginal or inadequate health literacy

by Wolters Kluwer HealthCredit: Wikimedia CommonsLow health literacy is a problem for a substantial proportion of people with moderate to severe traumatic brain injury (TBI),according

Updated on: March 30,2024

Nearly one-third of patients with TBI have marginal or inadequate health literacy

by Wolters Kluwer HealthCredit: Wikimedia CommonsLow health literacy is a problem for a substantial proportion of people with moderate to severe traumatic brain injury (TBI),according

Updated on:March 30,2024