Why is the brain so prone to inflammation?

by Sarah C.P. Williams,Columbia University Irving Medical CenterKeeping neuroinflammation in check. Normal neurons (top panel) produce a small amount of double-stranded DNA (green) that keeps in

Updated on: March 19,2024 11

Why is the brain so prone to inflammation?

by Sarah C.P. Williams,Columbia University Irving Medical CenterKeeping neuroinflammation in check. Normal neurons (top panel) produce a small amount of double-stranded DNA (green) that keeps in

Updated on:March 19,2024 11

Study finds frexalimab has favorable effect on relapsing multiple sclerosis

FEBRUARY 15, 2024by Elana GotkineFor patients with relapsing multiple sclerosis, the anti-CD40L monoclonal antibody frexalimab has a favorable effect on the number of new gadolinium-enhancing T1-weigh

Updated on: March 28,2024 2

Study finds frexalimab has favorable effect on relapsing multiple sclerosis

FEBRUARY 15, 2024by Elana GotkineFor patients with relapsing multiple sclerosis, the anti-CD40L monoclonal antibody frexalimab has a favorable effect on the number of new gadolinium-enhancing T1-weigh

Updated on:March 28,2024 2

How dopaminergic systems in fruit flies create reward-seeking behaviors despite adverse consequences

by Bob Yirka , Medical XpressReward DAN activity reduces subsequent need seeking. a, Left, schematics and experimental protocol. Right, starved flies trained with 0273-neuron activation (orange) disre

Updated on: January 11,2024 16

How dopaminergic systems in fruit flies create reward-seeking behaviors despite adverse consequences

by Bob Yirka , Medical XpressReward DAN activity reduces subsequent need seeking. a, Left, schematics and experimental protocol. Right, starved flies trained with 0273-neuron activation (orange) disre

Updated on:January 11,2024 16

Finding flicker's therapeutic pathway, opening the door to non-invasive treatments for neurodegenerative diseases

by Jerry Grillo,Georgia Institute of TechnologyProposed mechanisms by which 40 Hz flicker changes microglia and cytokine signaling. Credit:Science Advances(2023). DOI: 10.1126/sciadv

Updated on: May 28,2024 7

Finding flicker's therapeutic pathway, opening the door to non-invasive treatments for neurodegenerative diseases

by Jerry Grillo,Georgia Institute of TechnologyProposed mechanisms by which 40 Hz flicker changes microglia and cytokine signaling. Credit:Science Advances(2023). DOI: 10.1126/sciadv

Updated on:May 28,2024 7

Digital detection of dementia: Using AI to identify undiagnosed cases

by Regenstrief InstituteOur two trials are highly pragmatic as indicated by scores of 4 and 5 (‘most pragmatic’) in the PRECIS-2 summary wheel depicted here. The diverse primary care settings, mi

Updated on: May 06,2024 14

Digital detection of dementia: Using AI to identify undiagnosed cases

by Regenstrief InstituteOur two trials are highly pragmatic as indicated by scores of 4 and 5 (‘most pragmatic’) in the PRECIS-2 summary wheel depicted here. The diverse primary care settings, mi

Updated on:May 06,2024 14

'Window into the brain': A simple blood test to diagnose ALS is both robust and repeatable

by Brain Chemistry LabsDr. Rachael Dunlop conducts real-time PCR on microRNA extracted from extracellular vesicles derived from blood samples from ALS patients. Credit: Paul Alan Cox, Brain Chemistry

Updated on: January 21,2024 18

'Window into the brain': A simple blood test to diagnose ALS is both robust and repeatable

by Brain Chemistry LabsDr. Rachael Dunlop conducts real-time PCR on microRNA extracted from extracellular vesicles derived from blood samples from ALS patients. Credit: Paul Alan Cox, Brain Chemistry

Updated on:January 21,2024 18

New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on: May 14,2024 0

New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on:May 14,2024 0

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease

FEBRUARY 23, 2024byJohns Hopkins UniversityNeurons that express Lag3 proteins (grey/white) can take in Tau proteins (red) compared with neighboring neurons that do not express Lag3. Credit: Xiao

Updated on: March 25,2024 11

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease

FEBRUARY 23, 2024byJohns Hopkins UniversityNeurons that express Lag3 proteins (grey/white) can take in Tau proteins (red) compared with neighboring neurons that do not express Lag3. Credit: Xiao

Updated on:March 25,2024 11

A century of research shows eating these compounds can help protect against heart disease and Alzheimer's

by Jara Pérez Jiménez, Cara Frankenfeld, Léopold L Fezeu Kamedjie, Margaret Slavin and Valentina A. Andreeva,The ConversationCredit: CC0 Public DomainPerhaps the word "polyphenol" mean

Updated on: February 24,2024 16

A century of research shows eating these compounds can help protect against heart disease and Alzheimer's

by Jara Pérez Jiménez, Cara Frankenfeld, Léopold L Fezeu Kamedjie, Margaret Slavin and Valentina A. Andreeva,The ConversationCredit: CC0 Public DomainPerhaps the word "polyphenol" mean

Updated on:February 24,2024 16

Can targeted therapies be applied to patients with Alzheimer's?

by Joe Lafata,University of UtahTara Mastren, center, is leading research into developing targeted alpha-particle therapies for patients with Alzheimer's. The University of Utah professor of

Updated on: August 26,2024 0

Can targeted therapies be applied to patients with Alzheimer's?

by Joe Lafata,University of UtahTara Mastren, center, is leading research into developing targeted alpha-particle therapies for patients with Alzheimer's. The University of Utah professor of

Updated on:August 26,2024 0

Even in midlife, disrupted sleep tied to memory and thinking problems later on

byAmerican Academy of NeurologyCredit: Unsplash/CC0 Public DomainPeople who have more disrupted sleep in their 30s and 40s may be more likely to have memory and thinking problems a decade later,

Updated on: January 09,2024 10

Even in midlife, disrupted sleep tied to memory and thinking problems later on

byAmerican Academy of NeurologyCredit: Unsplash/CC0 Public DomainPeople who have more disrupted sleep in their 30s and 40s may be more likely to have memory and thinking problems a decade later,

Updated on:January 09,2024 10

Researchers highlight benefits of sharing human brain data

by Graciela Gutierrez,Baylor College of MedicineCredit: Unsplash/CC0 Public DomainIn recent years, the scientific community has seen a push for more findable, accessible, interoperable, and reus

Updated on: January 10,2024 6

Researchers highlight benefits of sharing human brain data

by Graciela Gutierrez,Baylor College of MedicineCredit: Unsplash/CC0 Public DomainIn recent years, the scientific community has seen a push for more findable, accessible, interoperable, and reus

Updated on:January 10,2024 6