New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on: May 14,2024

New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on:May 14,2024

Heat waves may increase the likelihood of seizures in people with epilepsy

byUniversity College LondonCredit:Brain Communications(2024). DOI: 10.1093/braincomms/fcae269Heat waves can worsen abnormal excitability of the brain in people with epilepsy, finds a

Updated on: October 03,2024

Heat waves may increase the likelihood of seizures in people with epilepsy

byUniversity College LondonCredit:Brain Communications(2024). DOI: 10.1093/braincomms/fcae269Heat waves can worsen abnormal excitability of the brain in people with epilepsy, finds a

Updated on:October 03,2024

Accumulation of 'junk proteins' identified as one cause of aging and possible source of ALS

byThe Spanish National Cancer Research CentreAccumulation of "junk proteins": normal cells (left) and cells subjected to the effect of the toxic arginine-rich protein (right). In the l

Updated on: March 27,2024

Accumulation of 'junk proteins' identified as one cause of aging and possible source of ALS

byThe Spanish National Cancer Research CentreAccumulation of "junk proteins": normal cells (left) and cells subjected to the effect of the toxic arginine-rich protein (right). In the l

Updated on:March 27,2024

Scientists uncover key brain pathway mediating panic disorder symptoms

bySalk InstitutePAC1R-expressing dorsal raphe neurons in the mouse brain (red) serve as the projection targets for PACAP parabrachial neurons to mediate panic-like behavioral and physical sympto

Updated on: January 09,2024

Scientists uncover key brain pathway mediating panic disorder symptoms

bySalk InstitutePAC1R-expressing dorsal raphe neurons in the mouse brain (red) serve as the projection targets for PACAP parabrachial neurons to mediate panic-like behavioral and physical sympto

Updated on:January 09,2024

Older adults with dementia but without close family: Who are they? And who cares for them?

by Janelle Taylor,The ConversationCredit: AI-generated imageWhat happens toolder adults who do not have close familywhen they developdementia? The truth is, we hardly know.Popu

Updated on: June 11,2024

Older adults with dementia but without close family: Who are they? And who cares for them?

by Janelle Taylor,The ConversationCredit: AI-generated imageWhat happens toolder adults who do not have close familywhen they developdementia? The truth is, we hardly know.Popu

Updated on:June 11,2024

Study links long-term consumption of reused deep-fried oil with increased neurodegeneration

byAmerican Society for Biochemistry and Molecular BiologyCredit: Pixabay/CC0 Public DomainA new study found higher levels of neurodegeneration in rats that consumed reused deep-fried cooking oil

Updated on: March 28,2024

Study links long-term consumption of reused deep-fried oil with increased neurodegeneration

byAmerican Society for Biochemistry and Molecular BiologyCredit: Pixabay/CC0 Public DomainA new study found higher levels of neurodegeneration in rats that consumed reused deep-fried cooking oil

Updated on:March 28,2024

MS treatment that 'resets' immune system may halt disease progression for at least five years

by Imperial College LondonDemyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100. Credit:CC BY-SA 3.0Marvin 101/Wikiped

Updated on: April 01,2024

MS treatment that 'resets' immune system may halt disease progression for at least five years

by Imperial College LondonDemyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100. Credit:CC BY-SA 3.0Marvin 101/Wikiped

Updated on:April 01,2024

More pain, more burdens: Researchers find link between chronic pain and dementia

by Chinese Academy of SciencesElevated dementia risk, cognitive decline, and hippocampalatrophy in multisite chronic pain. Credit: Tu YihengA research team led by Dr. Tu Yiheng from the Institute

Updated on: June 05,2024

More pain, more burdens: Researchers find link between chronic pain and dementia

by Chinese Academy of SciencesElevated dementia risk, cognitive decline, and hippocampalatrophy in multisite chronic pain. Credit: Tu YihengA research team led by Dr. Tu Yiheng from the Institute

Updated on:June 05,2024

Olive oil a powerful prescription against dementia

by Amy NortonPeople looking to stay mentally sharp as they age might want to swap out margarine for olive oil, a preliminary study suggests.The study, of more than 90,000 U.S. health professionals, fo

Updated on: June 04,2024

Olive oil a powerful prescription against dementia

by Amy NortonPeople looking to stay mentally sharp as they age might want to swap out margarine for olive oil, a preliminary study suggests.The study, of more than 90,000 U.S. health professionals, fo

Updated on:June 04,2024

Digital detection of dementia: Using AI to identify undiagnosed cases

by Regenstrief InstituteOur two trials are highly pragmatic as indicated by scores of 4 and 5 (‘most pragmatic’) in the PRECIS-2 summary wheel depicted here. The diverse primary care settings, mi

Updated on: May 06,2024

Digital detection of dementia: Using AI to identify undiagnosed cases

by Regenstrief InstituteOur two trials are highly pragmatic as indicated by scores of 4 and 5 (‘most pragmatic’) in the PRECIS-2 summary wheel depicted here. The diverse primary care settings, mi

Updated on:May 06,2024

A somewhat systematic review of previous systematic reviews and meta-analyses about nutrition and Alzheimer's

by Justin Jackson , Medical XpressCredit: Unsplash/CC0 Public DomainA team from the International Education College of Zhejiang Chinese Medical University, Hangzhou, China, has conducted a review of s

Updated on: May 26,2024

A somewhat systematic review of previous systematic reviews and meta-analyses about nutrition and Alzheimer's

by Justin Jackson , Medical XpressCredit: Unsplash/CC0 Public DomainA team from the International Education College of Zhejiang Chinese Medical University, Hangzhou, China, has conducted a review of s

Updated on:May 26,2024

Study: Gut health plays a role in Alzheimer's development

by Alzheimer's Research UKCredit: Pixabay/CC0 Public DomainA series of experiments presented today at the Alzheimer's Research UK 2022 Conference at the Brighton Centre, has implicated th

Updated on: April 20,2024

Study: Gut health plays a role in Alzheimer's development

by Alzheimer's Research UKCredit: Pixabay/CC0 Public DomainA series of experiments presented today at the Alzheimer's Research UK 2022 Conference at the Brighton Centre, has implicated th

Updated on:April 20,2024