A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of brain microglia

by Ingrid Fadelli , Medical XpressImages showing the architecture of our ATV:TREM2 molecule (a) images showing elevation of microglia proliferation in the brain of mice treated with ATV:TREM2 (b) a su

Updated on: March 26,2024

A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of brain microglia

by Ingrid Fadelli , Medical XpressImages showing the architecture of our ATV:TREM2 molecule (a) images showing elevation of microglia proliferation in the brain of mice treated with ATV:TREM2 (b) a su

Updated on:March 26,2024

Possible mechanism for fold formation in the cerebral cortex discovered

by Elena Garrido,Miguel Hernandez University of ElcheImage of a ferret brain showing the altered folding pattern (left) mediated by the Cux2 protein. Credit: IN-CSIC-UMH.Determining the genetic

Updated on: June 15,2024

Possible mechanism for fold formation in the cerebral cortex discovered

by Elena Garrido,Miguel Hernandez University of ElcheImage of a ferret brain showing the altered folding pattern (left) mediated by the Cux2 protein. Credit: IN-CSIC-UMH.Determining the genetic

Updated on:June 15,2024

Interfering with antiviral pathway may deter Alzheimer's disease and frontotemporal dementia

by Weill Cornell Medical CollegeThe cGAS–STING pathway is activated in the hippocampi of mice with tauopathy and in human AD brains. Credit:Nature Neuroscience(2023). DOI: 10.1038/s41

Updated on: June 04,2024

Interfering with antiviral pathway may deter Alzheimer's disease and frontotemporal dementia

by Weill Cornell Medical CollegeThe cGAS–STING pathway is activated in the hippocampi of mice with tauopathy and in human AD brains. Credit:Nature Neuroscience(2023). DOI: 10.1038/s41

Updated on:June 04,2024

The high costs of Alzheimer's

(HealthDay)—Sharp increases in Alzheimer's disease cases, deaths and costs are stressing the U.S. health care system and caregivers, a new report reveals.About 5.7 million Americans have Alzheimer

Updated on: April 18,2024

The high costs of Alzheimer's

(HealthDay)—Sharp increases in Alzheimer's disease cases, deaths and costs are stressing the U.S. health care system and caregivers, a new report reveals.About 5.7 million Americans have Alzheimer

Updated on:April 18,2024

Study discovers connection between between heart and brain in KBG syndrome

byUniversity of AlbertaAnkrd11is expressed in cardiac neural crest cells and ablated in theAnkrd11nckomouse model. Credit:Nature Communications(2024). DOI: 10.1038/

Updated on: July 05,2024

Study discovers connection between between heart and brain in KBG syndrome

byUniversity of AlbertaAnkrd11is expressed in cardiac neural crest cells and ablated in theAnkrd11nckomouse model. Credit:Nature Communications(2024). DOI: 10.1038/

Updated on:July 05,2024

Tau-regulating protein identified as a promising target for developing Alzheimer's disease treatment

by Perelman School of Medicine at the University of PennsylvaniaIndividuals with Alzheimer’s disease (AD) have increased neurofibrillary tangles (NFTs) of tau proteins but reduced TRIM11, as show

Updated on: April 02,2024

Tau-regulating protein identified as a promising target for developing Alzheimer's disease treatment

by Perelman School of Medicine at the University of PennsylvaniaIndividuals with Alzheimer’s disease (AD) have increased neurofibrillary tangles (NFTs) of tau proteins but reduced TRIM11, as show

Updated on:April 02,2024

New insight into protein production in brain could help tackle dementia

by University College LondonCredit: Pixabay/CC0 Public DomainA pioneering new study led by UCL scientists has revealed, for the first time, a layer of genetic material involved in controlling the

Updated on: May 26,2024

New insight into protein production in brain could help tackle dementia

by University College LondonCredit: Pixabay/CC0 Public DomainA pioneering new study led by UCL scientists has revealed, for the first time, a layer of genetic material involved in controlling the

Updated on:May 26,2024

How dopaminergic systems in fruit flies create reward-seeking behaviors despite adverse consequences

by Bob Yirka , Medical XpressReward DAN activity reduces subsequent need seeking. a, Left, schematics and experimental protocol. Right, starved flies trained with 0273-neuron activation (orange) disre

Updated on: January 11,2024

How dopaminergic systems in fruit flies create reward-seeking behaviors despite adverse consequences

by Bob Yirka , Medical XpressReward DAN activity reduces subsequent need seeking. a, Left, schematics and experimental protocol. Right, starved flies trained with 0273-neuron activation (orange) disre

Updated on:January 11,2024

Serotonin-producing neurons regulate malignancy in ependymoma brain tumors

byBaylor College of MedicineStimulation of serotonergic neurons suppresses EPN tumorigenesis. Credit:Nature(2024). DOI: 10.1038/s41586-024-07751-zA study published inNature&nbs

Updated on: August 26,2024

Serotonin-producing neurons regulate malignancy in ependymoma brain tumors

byBaylor College of MedicineStimulation of serotonergic neurons suppresses EPN tumorigenesis. Credit:Nature(2024). DOI: 10.1038/s41586-024-07751-zA study published inNature&nbs

Updated on:August 26,2024

Blood tests for Alzheimer's: Why new studies are encouraging

by Todd Golde And Steven Dekosky,The ConversationCredit: AI-generated imageMany people who have problems with their memory, especially if they are elderly, worry that they have Alzheimer's d

Updated on: April 18,2024

Blood tests for Alzheimer's: Why new studies are encouraging

by Todd Golde And Steven Dekosky,The ConversationCredit: AI-generated imageMany people who have problems with their memory, especially if they are elderly, worry that they have Alzheimer's d

Updated on:April 18,2024

Preliminary stages of dementia reduce human face memorization ability

by Kumamoto University[LEFT] Patients with mild cognitive impairment (MCI) have a significantly reduced ability to memorize faces in comparison to healthy controls (HCs). [RIGHT] The gaze pattern

Updated on: May 06,2024

Preliminary stages of dementia reduce human face memorization ability

by Kumamoto University[LEFT] Patients with mild cognitive impairment (MCI) have a significantly reduced ability to memorize faces in comparison to healthy controls (HCs). [RIGHT] The gaze pattern

Updated on:May 06,2024

Devastating causes of childhood dementia revealed

by Jessica Stanley,University of AdelaideOverall survival of the cohort born with currently untreatable childhood dementia. Credit:Brain(2023). DOI: 10.1093/brain/awad242It is a hear

Updated on: March 02,2024

Devastating causes of childhood dementia revealed

by Jessica Stanley,University of AdelaideOverall survival of the cohort born with currently untreatable childhood dementia. Credit:Brain(2023). DOI: 10.1093/brain/awad242It is a hear

Updated on:March 02,2024