New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on: May 14,2024

New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on:May 14,2024

Immune cells identified as key players in brain health

byThe Mount Sinai HospitalThe Icahn Mount Sinai researchers nominated and validated transcription factors BHLHE40 and BHLHE41 that regulate clearance processes in immune cells, including brain i

Updated on: March 27,2024

Immune cells identified as key players in brain health

byThe Mount Sinai HospitalThe Icahn Mount Sinai researchers nominated and validated transcription factors BHLHE40 and BHLHE41 that regulate clearance processes in immune cells, including brain i

Updated on:March 27,2024

'Spatial Computing' enables flexible working memory

byMassachusetts Institute of TechnologyTriangles represent neurons. Colors represent specific information they encode. The ovals represent patches in which brain waves represent task rules. For

Updated on: January 21,2024

'Spatial Computing' enables flexible working memory

byMassachusetts Institute of TechnologyTriangles represent neurons. Colors represent specific information they encode. The ovals represent patches in which brain waves represent task rules. For

Updated on:January 21,2024

Radiation breaks connections in the brain

by University of Rochester Medical CenterImage from study shows protein marker (green) that indicates activation of microglia (red) after exposure to radiation. Credit: University of Rochester Me

Updated on: June 01,2024

Radiation breaks connections in the brain

by University of Rochester Medical CenterImage from study shows protein marker (green) that indicates activation of microglia (red) after exposure to radiation. Credit: University of Rochester Me

Updated on:June 01,2024

Researchers identify path to prevent cognitive decline after radiation

by Kelsie Smith Hayduk,University of Rochester Medical CenterCredit: Pixabay/CC0 Public DomainResearchers at the Del Monte Institute for Neuroscience at the University of Rochester find that mic

Updated on: January 09,2024

Researchers identify path to prevent cognitive decline after radiation

by Kelsie Smith Hayduk,University of Rochester Medical CenterCredit: Pixabay/CC0 Public DomainResearchers at the Del Monte Institute for Neuroscience at the University of Rochester find that mic

Updated on:January 09,2024

Newly discovered mechanism reveals NAD's role in aging and disease

byUniversity of BergenProposed model for the cooperation of SLC25A51 and NMNAT3 to buffer cellular NAD+fluctuations. Credit:Nature Metabolism(2024). DOI: 10.1038/s42255-024-011

Updated on: February 01,2025

Newly discovered mechanism reveals NAD's role in aging and disease

byUniversity of BergenProposed model for the cooperation of SLC25A51 and NMNAT3 to buffer cellular NAD+fluctuations. Credit:Nature Metabolism(2024). DOI: 10.1038/s42255-024-011

Updated on:February 01,2025

Study unveils a cortico-amygdala neural substrate supporting fear extinction via endocannabinoids

by Ingrid Fadelli , Medical XpressZooming into fear and endocannabinoids in the brain. Credit: Ozge Gunduz-Cinar and Biorender.Endogenous cannabinoids, or endocannabinoids for short, are lipid-based n

Updated on: January 11,2024

Study unveils a cortico-amygdala neural substrate supporting fear extinction via endocannabinoids

by Ingrid Fadelli , Medical XpressZooming into fear and endocannabinoids in the brain. Credit: Ozge Gunduz-Cinar and Biorender.Endogenous cannabinoids, or endocannabinoids for short, are lipid-based n

Updated on:January 11,2024

Scientists discover a new set of cells that control the blood-brain barrier

byUniversity of Western AustraliaAstrocytes transfer mitochondria and alleviate oxidative stress of endothelial cells. Credit:Science Advances(2024). DOI: 10.1126/sciadv.adk2913Resea

Updated on: July 08,2024

Scientists discover a new set of cells that control the blood-brain barrier

byUniversity of Western AustraliaAstrocytes transfer mitochondria and alleviate oxidative stress of endothelial cells. Credit:Science Advances(2024). DOI: 10.1126/sciadv.adk2913Resea

Updated on:July 08,2024

A century of research shows eating these compounds can help protect against heart disease and Alzheimer's

by Jara Pérez Jiménez, Cara Frankenfeld, Léopold L Fezeu Kamedjie, Margaret Slavin and Valentina A. Andreeva,The ConversationCredit: CC0 Public DomainPerhaps the word "polyphenol" mean

Updated on: February 24,2024

A century of research shows eating these compounds can help protect against heart disease and Alzheimer's

by Jara Pérez Jiménez, Cara Frankenfeld, Léopold L Fezeu Kamedjie, Margaret Slavin and Valentina A. Andreeva,The ConversationCredit: CC0 Public DomainPerhaps the word "polyphenol" mean

Updated on:February 24,2024

Florida doctors use saliva test to reveal someone's future risk for Alzheimer's

by Cindy Krischer GoodmanCredit: Pixabay/CC0 Public DomainFlorida doctors are using a new test to determine someone's future risk for Alzheimer's disease from a few drops of spit.At a time whe

Updated on: June 01,2024

Florida doctors use saliva test to reveal someone's future risk for Alzheimer's

by Cindy Krischer GoodmanCredit: Pixabay/CC0 Public DomainFlorida doctors are using a new test to determine someone's future risk for Alzheimer's disease from a few drops of spit.At a time whe

Updated on:June 01,2024

Scientists leverage machine learning to decode gene regulation in the developing human brain

byGladstone InstitutesMassively parallel characterization and prediction of gene regulatory activity in the developing brain. Credit:Science(2024). DOI: 10.1126/science.adh0559In a s

Updated on: May 30,2024

Scientists leverage machine learning to decode gene regulation in the developing human brain

byGladstone InstitutesMassively parallel characterization and prediction of gene regulatory activity in the developing brain. Credit:Science(2024). DOI: 10.1126/science.adh0559In a s

Updated on:May 30,2024

Higher levels of lean muscle might protect against Alzheimer's disease

by British Medical JournalCredit: Unsplash/CC0 Public DomainHigh levels of lean muscle might protect against Alzheimer's disease, suggests a large study published in the open access journal&n

Updated on: June 04,2024

Higher levels of lean muscle might protect against Alzheimer's disease

by British Medical JournalCredit: Unsplash/CC0 Public DomainHigh levels of lean muscle might protect against Alzheimer's disease, suggests a large study published in the open access journal&n

Updated on:June 04,2024