New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on: May 14,2024

New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on:May 14,2024

Radiation breaks connections in the brain

by University of Rochester Medical CenterImage from study shows protein marker (green) that indicates activation of microglia (red) after exposure to radiation. Credit: University of Rochester Me

Updated on: June 01,2024

Radiation breaks connections in the brain

by University of Rochester Medical CenterImage from study shows protein marker (green) that indicates activation of microglia (red) after exposure to radiation. Credit: University of Rochester Me

Updated on:June 01,2024

Study unveils a cortico-amygdala neural substrate supporting fear extinction via endocannabinoids

by Ingrid Fadelli , Medical XpressZooming into fear and endocannabinoids in the brain. Credit: Ozge Gunduz-Cinar and Biorender.Endogenous cannabinoids, or endocannabinoids for short, are lipid-based n

Updated on: January 11,2024

Study unveils a cortico-amygdala neural substrate supporting fear extinction via endocannabinoids

by Ingrid Fadelli , Medical XpressZooming into fear and endocannabinoids in the brain. Credit: Ozge Gunduz-Cinar and Biorender.Endogenous cannabinoids, or endocannabinoids for short, are lipid-based n

Updated on:January 11,2024

Scientists discover a new set of cells that control the blood-brain barrier

byUniversity of Western AustraliaAstrocytes transfer mitochondria and alleviate oxidative stress of endothelial cells. Credit:Science Advances(2024). DOI: 10.1126/sciadv.adk2913Resea

Updated on: July 08,2024

Scientists discover a new set of cells that control the blood-brain barrier

byUniversity of Western AustraliaAstrocytes transfer mitochondria and alleviate oxidative stress of endothelial cells. Credit:Science Advances(2024). DOI: 10.1126/sciadv.adk2913Resea

Updated on:July 08,2024

Research finds sex differences in immune response and metabolism drive Alzheimer's disease

by Cleveland ClinicCredit: CC0 Public DomainCleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer's and found that differences in brain immunometabolism—the

Updated on: February 24,2024

Research finds sex differences in immune response and metabolism drive Alzheimer's disease

by Cleveland ClinicCredit: CC0 Public DomainCleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer's and found that differences in brain immunometabolism—the

Updated on:February 24,2024

Team explores role of 'stimulator of interferon genes' in body's innate immune system

by Tokai National Higher Education and Research SystemA graphical illustration of cholesterol- and palmitoylation-dependent STING clustering at the TGN. Credit: Institute for Glyco-core ResearchWhen p

Updated on: June 18,2024

Team explores role of 'stimulator of interferon genes' in body's innate immune system

by Tokai National Higher Education and Research SystemA graphical illustration of cholesterol- and palmitoylation-dependent STING clustering at the TGN. Credit: Institute for Glyco-core ResearchWhen p

Updated on:June 18,2024

Insights on FDA's controversial approval of Alzheimer's drug

by Patrick Ercolano,Johns Hopkins UniversitySupriya Munshaw. Credit: Johns Hopkins UniversityThe U.S. Food and Drug Administration's recent approval of aducanumab, a treatment for Alzheimer&

Updated on: May 22,2024

Insights on FDA's controversial approval of Alzheimer's drug

by Patrick Ercolano,Johns Hopkins UniversitySupriya Munshaw. Credit: Johns Hopkins UniversityThe U.S. Food and Drug Administration's recent approval of aducanumab, a treatment for Alzheimer&

Updated on:May 22,2024

Florida doctors use saliva test to reveal someone's future risk for Alzheimer's

by Cindy Krischer GoodmanCredit: Pixabay/CC0 Public DomainFlorida doctors are using a new test to determine someone's future risk for Alzheimer's disease from a few drops of spit.At a time whe

Updated on: June 01,2024

Florida doctors use saliva test to reveal someone's future risk for Alzheimer's

by Cindy Krischer GoodmanCredit: Pixabay/CC0 Public DomainFlorida doctors are using a new test to determine someone's future risk for Alzheimer's disease from a few drops of spit.At a time whe

Updated on:June 01,2024

Brain neurotransmitter receptor antagonist found to prevent opioid addiction in mice

byUniversity of California, Los AngelesSuvorexant blocked microglial activation in the hypothalamus and VTA. Credit:Nature Mental Health(2024). DOI: 10.1038/s44220-024-00278-2New res

Updated on: July 10,2024

Brain neurotransmitter receptor antagonist found to prevent opioid addiction in mice

byUniversity of California, Los AngelesSuvorexant blocked microglial activation in the hypothalamus and VTA. Credit:Nature Mental Health(2024). DOI: 10.1038/s44220-024-00278-2New res

Updated on:July 10,2024

At-home cognitive assessment performs as well as widely used, clinician-led test

by Baycrest Centre for Geriatric CareCredit: Pixabay/CC0 Public DomainThe Baycrest-developed, at-home Cogniciti Brain Health Assessment performs as well as a widely used, clinician-led test at as

Updated on: June 20,2024

At-home cognitive assessment performs as well as widely used, clinician-led test

by Baycrest Centre for Geriatric CareCredit: Pixabay/CC0 Public DomainThe Baycrest-developed, at-home Cogniciti Brain Health Assessment performs as well as a widely used, clinician-led test at as

Updated on:June 20,2024

Immune cells identified as key players in brain health

byThe Mount Sinai HospitalThe Icahn Mount Sinai researchers nominated and validated transcription factors BHLHE40 and BHLHE41 that regulate clearance processes in immune cells, including brain i

Updated on: March 27,2024

Immune cells identified as key players in brain health

byThe Mount Sinai HospitalThe Icahn Mount Sinai researchers nominated and validated transcription factors BHLHE40 and BHLHE41 that regulate clearance processes in immune cells, including brain i

Updated on:March 27,2024

'Spatial Computing' enables flexible working memory

byMassachusetts Institute of TechnologyTriangles represent neurons. Colors represent specific information they encode. The ovals represent patches in which brain waves represent task rules. For

Updated on: January 21,2024

'Spatial Computing' enables flexible working memory

byMassachusetts Institute of TechnologyTriangles represent neurons. Colors represent specific information they encode. The ovals represent patches in which brain waves represent task rules. For

Updated on:January 21,2024