Machine-learning program reveals genes responsible for sex-specific differences in Alzheimer's disease progression

by Texas Children's HospitalThe top 98 EAML genes are connected to GWAS genes, dysregulated in AD patients, and capable of separating AD and healthy control samples. Credit:Nature Commu

Updated on: June 11,2024

Machine-learning program reveals genes responsible for sex-specific differences in Alzheimer's disease progression

by Texas Children's HospitalThe top 98 EAML genes are connected to GWAS genes, dysregulated in AD patients, and capable of separating AD and healthy control samples. Credit:Nature Commu

Updated on:June 11,2024

Analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

by Liu Jia,Chinese Academy of SciencesStable real-time analysis of optical imaging of large-scale neuronal activities. a, FX design-based real-time analysis system for large-scale imaging, in co

Updated on: March 19,2024

Analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics

by Liu Jia,Chinese Academy of SciencesStable real-time analysis of optical imaging of large-scale neuronal activities. a, FX design-based real-time analysis system for large-scale imaging, in co

Updated on:March 19,2024

A therapeutic target for Alzheimer's disease discovered

by Laval UniversityFRET ratio is independent of laser intensity, and imaging depth was comparable between NonTg and 5xFAD mice. (A) Confocal image of the AAV2/9.CaMKIIa.SuperClomeleon (SCLM) infe

Updated on: May 28,2024

A therapeutic target for Alzheimer's disease discovered

by Laval UniversityFRET ratio is independent of laser intensity, and imaging depth was comparable between NonTg and 5xFAD mice. (A) Confocal image of the AAV2/9.CaMKIIa.SuperClomeleon (SCLM) infe

Updated on:May 28,2024

New target for Alzheimer's therapies found

by German Center for Neurodegenerative DiseasesMedin interacts directly with amyloid-β, promoting its aggregation.a, Immuno-electron microscopy of MFG-E8 (or fragment) staining in cortical

Updated on: May 28,2024

New target for Alzheimer's therapies found

by German Center for Neurodegenerative DiseasesMedin interacts directly with amyloid-β, promoting its aggregation.a, Immuno-electron microscopy of MFG-E8 (or fragment) staining in cortical

Updated on:May 28,2024

Alzheimer's disease is partly genetic—studying the genes that delay decline in some may lead to treatments for all

by Steven DeKosky,The ConversationCredit: Unsplash/CC0 Public DomainDiseases that run in families usually have genetic causes. Some aregenetic mutationsthat directly cause the diseas

Updated on: March 02,2024

Alzheimer's disease is partly genetic—studying the genes that delay decline in some may lead to treatments for all

by Steven DeKosky,The ConversationCredit: Unsplash/CC0 Public DomainDiseases that run in families usually have genetic causes. Some aregenetic mutationsthat directly cause the diseas

Updated on:March 02,2024

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS disease

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS diseasebyTokyo Medical and Dental UniversityWe designed and synthesized both a conventional A

Updated on: May 30,2024

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS disease

Sweet move: A modified sugar enhances antisense oligonucleotide safety and efficacy for treating CNS diseasebyTokyo Medical and Dental UniversityWe designed and synthesized both a conventional A

Updated on:May 30,2024

Group calls on international community to prevent dementia by preventing stroke

by University of Western OntarioDr. Vladimir Hachinski. Credit: Western UniversityThe risk factors for stroke and dementia are the same, and a growing body of evidence demonstrates that preventin

Updated on: June 04,2024

Group calls on international community to prevent dementia by preventing stroke

by University of Western OntarioDr. Vladimir Hachinski. Credit: Western UniversityThe risk factors for stroke and dementia are the same, and a growing body of evidence demonstrates that preventin

Updated on:June 04,2024

Molecular mechanism behind HIV-associated dementia revealed

by Will Doss,Northwestern UniversityThe interaction between APP (red) and GAG (green) in the cell. Credit: Northwestern UniversityFor the first time, scientists have identified and inhibited a m

Updated on: March 30,2024

Molecular mechanism behind HIV-associated dementia revealed

by Will Doss,Northwestern UniversityThe interaction between APP (red) and GAG (green) in the cell. Credit: Northwestern UniversityFor the first time, scientists have identified and inhibited a m

Updated on:March 30,2024

Radiation breaks connections in the brain

by University of Rochester Medical CenterImage from study shows protein marker (green) that indicates activation of microglia (red) after exposure to radiation. Credit: University of Rochester Me

Updated on: June 01,2024

Radiation breaks connections in the brain

by University of Rochester Medical CenterImage from study shows protein marker (green) that indicates activation of microglia (red) after exposure to radiation. Credit: University of Rochester Me

Updated on:June 01,2024

Unique visual stimulation may be new treatment for Alzheimer's

by Massachusetts Institute of TechnologyProfessor Li-Huei Tsai, director of MIT's Picower Institute for Learning and Memory, and senior author of the study, which appears in the Dec. 7 online

Updated on: May 22,2024

Unique visual stimulation may be new treatment for Alzheimer's

by Massachusetts Institute of TechnologyProfessor Li-Huei Tsai, director of MIT's Picower Institute for Learning and Memory, and senior author of the study, which appears in the Dec. 7 online

Updated on:May 22,2024

How does the brain make memories?

by Cedars-Sinai Medical CenterCredit: CC0 Public DomainIn a study led by Cedars-Sinai, researchers have discovered two types of brain cells that play a key role in dividing continuous human exper

Updated on: February 21,2024

How does the brain make memories?

by Cedars-Sinai Medical CenterCredit: CC0 Public DomainIn a study led by Cedars-Sinai, researchers have discovered two types of brain cells that play a key role in dividing continuous human exper

Updated on:February 21,2024

Minimally invasive blood test for Alzheimer's disease

by Florey Institute of Neuroscience & Mental HealthCredit: Florey Institute of Neuroscience & Mental HealthScientists from Japan and Australia have teamed up to develop and validate a blood te

Updated on: April 18,2024

Minimally invasive blood test for Alzheimer's disease

by Florey Institute of Neuroscience & Mental HealthCredit: Florey Institute of Neuroscience & Mental HealthScientists from Japan and Australia have teamed up to develop and validate a blood te

Updated on:April 18,2024