Newly discovered genetic variant that causes Parkinson's disease clarifies why the condition develops and how to halt it

by Matthew Farrer,The ConversationSchematic outline of the methodological framework used in the study. Credit:The Lancet Neurology(2024). DOI: 10.1016/S1474-4422(24)00121-2Parkinson&

Updated on: April 27,2024 0

Newly discovered genetic variant that causes Parkinson's disease clarifies why the condition develops and how to halt it

by Matthew Farrer,The ConversationSchematic outline of the methodological framework used in the study. Credit:The Lancet Neurology(2024). DOI: 10.1016/S1474-4422(24)00121-2Parkinson&

Updated on:April 27,2024 0

Study uncovers multiple lineages of stem cells contributing to neuron production

by Elena Garrido,Miguel Hernandez University of ElcheDiversity of Radial Glia cells in the neonatal ferret cerebral cortex, labeled with green fluorescent protein and seen within the transparent

Updated on: April 27,2024 0

Study uncovers multiple lineages of stem cells contributing to neuron production

by Elena Garrido,Miguel Hernandez University of ElcheDiversity of Radial Glia cells in the neonatal ferret cerebral cortex, labeled with green fluorescent protein and seen within the transparent

Updated on:April 27,2024 0

New atlas of mRNA variants captures inner workings of the brain

byWeill Cornell Medical CollegeSummary of mouse brain cell subtype assignments by age and region. Credit:Nature Neuroscience(2024). DOI: 10.1038/s41593-024-01616-4Investigators at We

Updated on: April 27,2024 0

New atlas of mRNA variants captures inner workings of the brain

byWeill Cornell Medical CollegeSummary of mouse brain cell subtype assignments by age and region. Credit:Nature Neuroscience(2024). DOI: 10.1038/s41593-024-01616-4Investigators at We

Updated on:April 27,2024 0

PET scans uncover smoldering inflammation in MS patients

byBrigham and Women’s HospitalGroup comparisons of lnGALP scores in the CoGM and WM, CoT, and normalized brain volume in MS as compared with HC (A–D); in MS patients on H-DMT (HT) as compared wi

Updated on: April 27,2024 0

PET scans uncover smoldering inflammation in MS patients

byBrigham and Women’s HospitalGroup comparisons of lnGALP scores in the CoGM and WM, CoT, and normalized brain volume in MS as compared with HC (A–D); in MS patients on H-DMT (HT) as compared wi

Updated on:April 27,2024 0

Research uncovers differences between the sexes in sleep, circadian rhythms and metabolism

byUniversity of SouthamptonConceptual framework of sex differences in sleep and circadian rhythms. Credit:Sleep Medicine Reviews(2024). DOI: 10.1016/j.smrv.2024.101926A new review of

Updated on: April 27,2024 0

Research uncovers differences between the sexes in sleep, circadian rhythms and metabolism

byUniversity of SouthamptonConceptual framework of sex differences in sleep and circadian rhythms. Credit:Sleep Medicine Reviews(2024). DOI: 10.1016/j.smrv.2024.101926A new review of

Updated on:April 27,2024 0

New study identifies gene believed to be responsible for ALS and dementia

byCase Western Reserve UniversityRepresentative human spinal cord tissue imaged at 4X objective for DAPI (blue), CD80 (red), and Iba1 (green) from an C9ORF72 ALS case and a non-ALS control. Scal

Updated on: April 26,2024 0

New study identifies gene believed to be responsible for ALS and dementia

byCase Western Reserve UniversityRepresentative human spinal cord tissue imaged at 4X objective for DAPI (blue), CD80 (red), and Iba1 (green) from an C9ORF72 ALS case and a non-ALS control. Scal

Updated on:April 26,2024 0

Study reveals insights into link between genetic mutation and Parkinson's

by Bill Hathaway,Yale UniversityLRRK2 inhibits lysosomal protease activity in human iPSC-derived macrophages. (A) Airyscan live cell confocal micrographs showing lysosome labeling in human iPSC-

Updated on: April 26,2024 0

Study reveals insights into link between genetic mutation and Parkinson's

by Bill Hathaway,Yale UniversityLRRK2 inhibits lysosomal protease activity in human iPSC-derived macrophages. (A) Airyscan live cell confocal micrographs showing lysosome labeling in human iPSC-

Updated on:April 26,2024 0

Scientists identify how dietary restriction slows brain aging and increases lifespan

by Buck Institute for Research on Agingmtd interacts with the retromer complex and is required for retromer maintenance. Credit:Nature Communications(2024). DOI: 10.1038/s41467-023-44343-3

Updated on: April 26,2024 0

Scientists identify how dietary restriction slows brain aging and increases lifespan

by Buck Institute for Research on Agingmtd interacts with the retromer complex and is required for retromer maintenance. Credit:Nature Communications(2024). DOI: 10.1038/s41467-023-44343-3

Updated on:April 26,2024 0

Living with Alzheimer's: China's health time bomb

Credit: CC0 Public DomainThe first time Chen Shaohua went missing and was picked up by police, the 68-year-old's family put it down to confusion.When he disappeared a second time, they realised he

Updated on: April 25,2024 12

Living with Alzheimer's: China's health time bomb

Credit: CC0 Public DomainThe first time Chen Shaohua went missing and was picked up by police, the 68-year-old's family put it down to confusion.When he disappeared a second time, they realised he

Updated on:April 25,2024 12

Chaperone protein imbalance promotes toxic tau buildup in the aging brain

by University of South FloridaTau pathology resembling that seen in Alzheimer's disease brains. Credit: Laura Blair's laboratory, USF Health/University of South FloridaChaperone protein i

Updated on: April 25,2024 10

Chaperone protein imbalance promotes toxic tau buildup in the aging brain

by University of South FloridaTau pathology resembling that seen in Alzheimer's disease brains. Credit: Laura Blair's laboratory, USF Health/University of South FloridaChaperone protein i

Updated on:April 25,2024 10

'White matter lesion' mapping tool identifies early signs of dementia

by NYU Langone HealthCaption: MRI image of human brain shows multiple bright spots (white matter hyperintensities) in centerCourtesy of Elsevier/Academic Radiology. Credit: Elsevier/Academic Radi

Updated on: April 25,2024 10

'White matter lesion' mapping tool identifies early signs of dementia

by NYU Langone HealthCaption: MRI image of human brain shows multiple bright spots (white matter hyperintensities) in centerCourtesy of Elsevier/Academic Radiology. Credit: Elsevier/Academic Radi

Updated on:April 25,2024 10

Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers

by Bar-Ilan University(A) Potential influence of azaGly residue on hydrogen-bonding of cyclic D,L-α-hexapeptide nanotubes which share common cross β-sheet structures with (B) Aβ. For clarity, all

Updated on: April 25,2024 15

Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers

by Bar-Ilan University(A) Potential influence of azaGly residue on hydrogen-bonding of cyclic D,L-α-hexapeptide nanotubes which share common cross β-sheet structures with (B) Aβ. For clarity, all

Updated on:April 25,2024 15