Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on: April 16,2024 15

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on:April 16,2024 15

Alzheimer's drug gantenerumab fails to slow decline in phase III clinical trial

by Alzheimer's Research UKCredit: Pixabay/CC0 Public DomainThe pharmaceutical company Roche has announced that two phase III trials of the potential Alzheimer's drug gantenerumab did not

Updated on: April 16,2024 14

Alzheimer's drug gantenerumab fails to slow decline in phase III clinical trial

by Alzheimer's Research UKCredit: Pixabay/CC0 Public DomainThe pharmaceutical company Roche has announced that two phase III trials of the potential Alzheimer's drug gantenerumab did not

Updated on:April 16,2024 14

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on: April 16,2024 13

Alzheimer's drug development pipeline: Promising therapies, pharma investment drive momentum in clinical trials

by University of Nevada, Las VegasAgents in clinical trials for treatment of Alzheimer's disease in 2023 (from ClinicalTrials.gov as of the index date of January 1, 2023). The inner ring show

Updated on:April 16,2024 13

Alzheimer's research strengthens evidence for reanalyzing data in clinical trials that 'failed'

by Ellen Goldbaum,University at BuffaloCredit: Unsplash/CC0 Public DomainNew research on Alzheimer's disease led by the University at Buffalo reveals strong evidence that clinical trials on

Updated on: April 16,2024 14

Alzheimer's research strengthens evidence for reanalyzing data in clinical trials that 'failed'

by Ellen Goldbaum,University at BuffaloCredit: Unsplash/CC0 Public DomainNew research on Alzheimer's disease led by the University at Buffalo reveals strong evidence that clinical trials on

Updated on:April 16,2024 14

Progress on early detection of Alzheimer's disease

by Laurie Fickman,University of HoustonCredit: Pixabay/CC0 Public DomainInside the body, some seemingly harmless proteins have sinister potential. In the case of Alzheimer's disease, the amy

Updated on: April 16,2024 15

Progress on early detection of Alzheimer's disease

by Laurie Fickman,University of HoustonCredit: Pixabay/CC0 Public DomainInside the body, some seemingly harmless proteins have sinister potential. In the case of Alzheimer's disease, the amy

Updated on:April 16,2024 15

Good news, bad news from Alzheimer's vaccine trial

by Marianne Madeiros and Robin FosterAn experimental Alzheimer's vaccine appears to safely clear abnormal tau protein from the brain, but it's not yet clear whether the shot will be able to sa

Updated on: April 16,2024 14

Good news, bad news from Alzheimer's vaccine trial

by Marianne Madeiros and Robin FosterAn experimental Alzheimer's vaccine appears to safely clear abnormal tau protein from the brain, but it's not yet clear whether the shot will be able to sa

Updated on:April 16,2024 14

Protein shapes matter in Alzheimer's research

by Allison Mills,Michigan Technological UniversityCellular toxicity, which is higher in amyloid amorphous aggregates, shows that small changes in protein folding chemistry can cause differences

Updated on: April 16,2024 12

Protein shapes matter in Alzheimer's research

by Allison Mills,Michigan Technological UniversityCellular toxicity, which is higher in amyloid amorphous aggregates, shows that small changes in protein folding chemistry can cause differences

Updated on:April 16,2024 12

Consistent gene changes in Alzheimer's disease across studies

by Society for NeuroscienceTop 20 up and down-regulated genes for late phase Alzheimer's disease. Credit: Zhuang et al.,eNeuro2019A comparison of mouse Alzheimer's disease mod

Updated on: April 16,2024 10

Consistent gene changes in Alzheimer's disease across studies

by Society for NeuroscienceTop 20 up and down-regulated genes for late phase Alzheimer's disease. Credit: Zhuang et al.,eNeuro2019A comparison of mouse Alzheimer's disease mod

Updated on:April 16,2024 10

Investigational Alzheimer's drug improves biomarkers of the disease

by Washington University School of MedicineRandall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate e

Updated on: April 16,2024 11

Investigational Alzheimer's drug improves biomarkers of the disease

by Washington University School of MedicineRandall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate e

Updated on:April 16,2024 11

Alzheimer's: Blood biomarker may help identify the disease ten years before symptoms start

by Caroline Graff and Charlotte Johansson,The ConversationCredit: AI-generated imageThough Alzheimer's disease affects more than55 million people worldwide, there's still no cure f

Updated on: April 16,2024 17

Alzheimer's: Blood biomarker may help identify the disease ten years before symptoms start

by Caroline Graff and Charlotte Johansson,The ConversationCredit: AI-generated imageThough Alzheimer's disease affects more than55 million people worldwide, there's still no cure f

Updated on:April 16,2024 17

Alzheimer's disease is composed of four distinct subtypes

by Lund UniversityCredit: Unsplash/CC0 Public DomainAlzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can no

Updated on: April 16,2024 12

Alzheimer's disease is composed of four distinct subtypes

by Lund UniversityCredit: Unsplash/CC0 Public DomainAlzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can no

Updated on:April 16,2024 12

No cure for Alzheimer's disease in my lifetime

by Norman A. Paradis,The ConversationCredit: SAM LIN from PexelsBiogen recently announced that it was abandoning its late stage drug for Alzheimer's,aducanumab, causing investors to&nb

Updated on: April 16,2024 20

No cure for Alzheimer's disease in my lifetime

by Norman A. Paradis,The ConversationCredit: SAM LIN from PexelsBiogen recently announced that it was abandoning its late stage drug for Alzheimer's,aducanumab, causing investors to&nb

Updated on:April 16,2024 20