by Kayla Wiles, Purdue University

Automated supine pressor test procedure. Researchers are developing a way for women to test themselves for preeclampsia risk at home using a smartphone and automated blood pressure cuff. Credit: Purdue University

Roughly 15% of premature births in the U.S. happen due to a pregnancy complication caused by high blood pressure, called preeclampsia. While sometimes symptoms dissipate after the mother gives birth, preeclampsia can lead to permanent damage to the kidneys or death.

Purdue University researchers and colleagues, including Drs. David Reuter from Seattle Children's Hospital and David Haas from Indiana University School of Medicine, have been developing technology that would help a patient assess her risk for developing preeclampsia risk using a smartphone and an ambulatory blood pressure cuff. The device will automatically detect changes in her blood pressure indicative of preeclampsia as she switches between lying on her back and left side.

In a pilot study of 25 women at least 20 weeks pregnant, the majority of participants found the procedure easy to follow and the cuff comfortable to use, demonstrating the feasibility of making the device an autonomous self-test. Another key finding from this work was that when women rested on their side, their blood pressure was significantly lower.

The study was recently published in the Journal of Engineering and Science in Medical Diagnostics and Therapy. The researchers are aiming to advance the prototype to an autonomous device in the coming year.

"The goal is to not only identify patients with preeclampsia, but to also inform the patient that she is at higher risk for developing this condition in a week or a month from now," said Craig Goergen, the Leslie A. Geddes Associate Professor of Biomedical Engineering at Purdue.

The technology is an automated version of a simple test developed in the 1970s that measures changes in a woman's blood pressure in different positions. Called the supine pressor test, the method was accurate but fell out of use because of inconsistencies in the testing procedure leading to incorrect measurements.

"When this test was used in clinics, everybody was doing it slightly differently. What does 'left side' mean? How long does it take? It was not working well and was basically neglected," Goergen said.

"But if we could automate this test to indicate to the patient when her BP has stabilized, for example, then this test could be performed by the patient herself at home."

The researchers asked participants to take their blood pressure lying on their side and then on their back. A smartphone app helped the participants know that they were positioned in the correct position each time. The study also observed how 50 non-pregnant women used the device as a baseline.

Especially for parts of the world with high preeclampsia rates but poor access to a clinic, the researchers believe that such a device could reduce mortality rates.

 "This device has a lot of potential to help pregnant women in many different settings, particularly rural and underdeveloped ones," said Hamna Qureshi, a former Purdue master's student in biomedical engineering and first author on this paper.

More information: Hamna Qureshi et al. Towards Automation of the Supine Pressor Test FOR Preeclampsia, Journal of Engineering and Science in Medical Diagnostics and Therapy (2019). DOI: 10.1115/1.4045203

Provided by Purdue University