Novel genomics tool enables more accurate identification of rare mutations in cancer cells

by New York Genome CenterExample of colored de Bruijn graph rendered to represent genomic data for a short region of 400 base pairs using the Lancet genomics tool developed by New York Genome Center s

Updated on: March 01,2024

Novel genomics tool enables more accurate identification of rare mutations in cancer cells

by New York Genome CenterExample of colored de Bruijn graph rendered to represent genomic data for a short region of 400 base pairs using the Lancet genomics tool developed by New York Genome Center s

Updated on:March 01,2024

Study shines light on impact of environment on neurocognitive outcomes in survivors of pediatric brain tumors

by St. Jude Children's Research HospitalCredit: Pixabay/CC0 Public DomainTo gain a clearer understanding of the differences between childhood cancer patients when it comes to the impact of ra

Updated on: February 01,2024

Study shines light on impact of environment on neurocognitive outcomes in survivors of pediatric brain tumors

by St. Jude Children's Research HospitalCredit: Pixabay/CC0 Public DomainTo gain a clearer understanding of the differences between childhood cancer patients when it comes to the impact of ra

Updated on:February 01,2024

New method to determine before surgery which prostate tumors pose a lethal threat

by Cold Spring Harbor LaboratoryScreen shot from a new genome-viewing program (single cell genomic viewer, or SCGV) that displays results of CSHL's innovative method for analyzing diagnostic

Updated on: April 22,2024

New method to determine before surgery which prostate tumors pose a lethal threat

by Cold Spring Harbor LaboratoryScreen shot from a new genome-viewing program (single cell genomic viewer, or SCGV) that displays results of CSHL's innovative method for analyzing diagnostic

Updated on:April 22,2024

Study uncovers epigenetic source of resistance to targeted therapy in EGFR-mutant lung cancer

by Dana-Farber Cancer InstituteCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.07.005When lung cancers driven by mutations in the EGFR gene become resistant to osimertinib or othe

Updated on: February 01,2024

Study uncovers epigenetic source of resistance to targeted therapy in EGFR-mutant lung cancer

by Dana-Farber Cancer InstituteCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.07.005When lung cancers driven by mutations in the EGFR gene become resistant to osimertinib or othe

Updated on:February 01,2024

Genomic sequencing panels to personalize cancer treatment beneficial in only 5% of the patients, finds study

byThe Spanish National Cancer Research CentreThe use of these panels following the recommended clinical criteria increases the efficacy of treatments and patient survival. Credit: underbau / CNI

Updated on: January 23,2024

Genomic sequencing panels to personalize cancer treatment beneficial in only 5% of the patients, finds study

byThe Spanish National Cancer Research CentreThe use of these panels following the recommended clinical criteria increases the efficacy of treatments and patient survival. Credit: underbau / CNI

Updated on:January 23,2024

Researchers use a new approach to hit an 'undruggable' target

by University of MichiganGraphical abstract. Credit:Nature Chemical Biology(2023). DOI: 10.1038/s41589-022-01248-4The protein STAT5 has long been an appealing target against cancer, b

Updated on: February 18,2024

Researchers use a new approach to hit an 'undruggable' target

by University of MichiganGraphical abstract. Credit:Nature Chemical Biology(2023). DOI: 10.1038/s41589-022-01248-4The protein STAT5 has long been an appealing target against cancer, b

Updated on:February 18,2024

Existing cancer drugs have potential to benefit thousands more patients, research shows

byInstitute of Cancer ResearchSF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. Credit:Nature Genetics(2023). DOI: 1

Updated on: January 16,2024

Existing cancer drugs have potential to benefit thousands more patients, research shows

byInstitute of Cancer ResearchSF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. Credit:Nature Genetics(2023). DOI: 1

Updated on:January 16,2024

Enzyme inhibition promotes bone formation and curbs the development of bone metastases, study finds

byGerman Cancer Research CenterNegative regulation of bone formation by TAM receptor MERTK.amRNA expression analysis of TAM receptor familyMertk,Tyro3,Axl,Gas

Updated on: January 23,2024

Enzyme inhibition promotes bone formation and curbs the development of bone metastases, study finds

byGerman Cancer Research CenterNegative regulation of bone formation by TAM receptor MERTK.amRNA expression analysis of TAM receptor familyMertk,Tyro3,Axl,Gas

Updated on:January 23,2024

Adcetris FDA approval expanded to include later-stage Hodgkin's

(HealthDay)—U.S. Food and Drug Administration approval of Adcetris (brentuximab vedotin) has been expanded to include adults with untreated stage III or IV classical Hodgkin's lymphoma, the agency

Updated on: March 30,2024

Adcetris FDA approval expanded to include later-stage Hodgkin's

(HealthDay)—U.S. Food and Drug Administration approval of Adcetris (brentuximab vedotin) has been expanded to include adults with untreated stage III or IV classical Hodgkin's lymphoma, the agency

Updated on:March 30,2024

Stopping the spread: Targeting tumor metastasis

by Tokyo Medical and Dental UniversityTakahashi et al. show that TGF-β generates a population of cancer cells under cell cycle arrest in G1 phase with high motility by inducing unique Slug/HMGA2-indep

Updated on: January 22,2024

Stopping the spread: Targeting tumor metastasis

by Tokyo Medical and Dental UniversityTakahashi et al. show that TGF-β generates a population of cancer cells under cell cycle arrest in G1 phase with high motility by inducing unique Slug/HMGA2-indep

Updated on:January 22,2024

Periostin shows promise to help fight a common form of esophageal cancer

byElsevierSchematic diagram of roles of periostin (POSTN) in the esophageal squamous cell carcinoma (ESCC) microenvironment. Direct contact with ESCC cells leads mesenchymal stem cells (MSCs) to

Updated on: April 28,2024

Periostin shows promise to help fight a common form of esophageal cancer

byElsevierSchematic diagram of roles of periostin (POSTN) in the esophageal squamous cell carcinoma (ESCC) microenvironment. Direct contact with ESCC cells leads mesenchymal stem cells (MSCs) to

Updated on:April 28,2024

Immune system B-cells can help predict HER2-positive breast cancer treatment response

byUNC Lineberger Comprehensive Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Ce

Updated on: January 02,2024

Immune system B-cells can help predict HER2-positive breast cancer treatment response

byUNC Lineberger Comprehensive Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Ce

Updated on:January 02,2024