Inhibition of prmt5 by repurposing market drugs: A fresh therapeutic pathway for cancer treatment

by TranSpreadDevelopment of AlphaLISA HTS screen to identify specific PRMT5 inhibitors. (A) Principle of AlphaLISA technique adapted to HTS. Biotinylated histone H4 (a well-known PRMT5 substrate) was

Updated on: January 04,2024

Inhibition of prmt5 by repurposing market drugs: A fresh therapeutic pathway for cancer treatment

by TranSpreadDevelopment of AlphaLISA HTS screen to identify specific PRMT5 inhibitors. (A) Principle of AlphaLISA technique adapted to HTS. Biotinylated histone H4 (a well-known PRMT5 substrate) was

Updated on:January 04,2024

Investigating the most allergen-inducing drugs

by Scientific Project LomonosovComparison of % of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) due to a specific pharmacological group among the total SRsAs structure and %

Updated on: May 06,2024

Investigating the most allergen-inducing drugs

by Scientific Project LomonosovComparison of % of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) due to a specific pharmacological group among the total SRsAs structure and %

Updated on:May 06,2024

Adjuvant nivolumab + ipilimumab lacks efficacy for localized renal cell carcinoma

Disease-free survival (DFS) does not differ with adjuvant nivolumab plus ipilimumab (NIVO+IPI) compared with placebo in patients with localized renal cell carcinoma (RCC) at high risk for postnephrect

Updated on: December 22,2023

Adjuvant nivolumab + ipilimumab lacks efficacy for localized renal cell carcinoma

Disease-free survival (DFS) does not differ with adjuvant nivolumab plus ipilimumab (NIVO+IPI) compared with placebo in patients with localized renal cell carcinoma (RCC) at high risk for postnephrect

Updated on:December 22,2023

Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors

bySt. Jude Children's Research HospitalTwo leucine zipper motifs endow ZipRs with constitutive signal transduction.a, Schematic of IL-2 receptor-based Zip2Rs with phosphorylated (p) JA

Updated on: January 26,2024

Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors

bySt. Jude Children's Research HospitalTwo leucine zipper motifs endow ZipRs with constitutive signal transduction.a, Schematic of IL-2 receptor-based Zip2Rs with phosphorylated (p) JA

Updated on:January 26,2024

Study describes treatment of secondary CNS involvement by aggressive lymphomas

by Sylvester Comprehensive Cancer CenterHodgkin lymphoma, nodular lymphocyte predominant (high-power view) Credit: Gabriel Caponetti, MD./Wikipedia/CC BY-SA 3.0Some patients with aggressive lymphomas

Updated on: June 28,2024

Study describes treatment of secondary CNS involvement by aggressive lymphomas

by Sylvester Comprehensive Cancer CenterHodgkin lymphoma, nodular lymphocyte predominant (high-power view) Credit: Gabriel Caponetti, MD./Wikipedia/CC BY-SA 3.0Some patients with aggressive lymphomas

Updated on:June 28,2024

Significant proportion of cancer drugs lack proof of added benefit, finds study

by British Medical JournalCredit: CC0 Public DomainMany cancer drugs approved by the European Medicines Agency (EMA) between 1995 and 2020 lack proof of added benefit, particularly those approved

Updated on: May 26,2024

Significant proportion of cancer drugs lack proof of added benefit, finds study

by British Medical JournalCredit: CC0 Public DomainMany cancer drugs approved by the European Medicines Agency (EMA) between 1995 and 2020 lack proof of added benefit, particularly those approved

Updated on:May 26,2024

Signs there is a problem with your prostate

by Jason HowlandProstate cancer cells. Credit: NIH Image GalleryNovember is the time of the Movember movement, which encourages growing a mustache during the month to raise awareness of men's heal

Updated on: February 20,2024

Signs there is a problem with your prostate

by Jason HowlandProstate cancer cells. Credit: NIH Image GalleryNovember is the time of the Movember movement, which encourages growing a mustache during the month to raise awareness of men's heal

Updated on:February 20,2024

Identification of colony stimulating factor 1 receptor offers new strategy for cancer immunotherapy

by Zhang Nannan,Chinese Academy of SciencesIHMT-CSF1R-833 alters the macrophage polarization in M2 macrophages derived from RAW264.7 cells by inducing the M1 macrophage phenotype. Credit: Liang

Updated on: December 25,2023

Identification of colony stimulating factor 1 receptor offers new strategy for cancer immunotherapy

by Zhang Nannan,Chinese Academy of SciencesIHMT-CSF1R-833 alters the macrophage polarization in M2 macrophages derived from RAW264.7 cells by inducing the M1 macrophage phenotype. Credit: Liang

Updated on:December 25,2023

How a little-known glycoprotein blocks a cancer cell's immune response

by University of MichiganThe interaction between STC1 and calreticulin. Credit: University of Michigan Rogel Cancer CenterIt was an unexpected discovery that started with an analysis of more than

Updated on: March 26,2024

How a little-known glycoprotein blocks a cancer cell's immune response

by University of MichiganThe interaction between STC1 and calreticulin. Credit: University of Michigan Rogel Cancer CenterIt was an unexpected discovery that started with an analysis of more than

Updated on:March 26,2024

Research details adaptation tactics of pancreatic cancer

byUniversity of OklahomaPSCs support cancer cell growth by the secretion of acetate under acidosis. Credit:Nature Cell Biology(2024). DOI: 10.1038/s41556-024-01372-4Like alien invade

Updated on: April 28,2024

Research details adaptation tactics of pancreatic cancer

byUniversity of OklahomaPSCs support cancer cell growth by the secretion of acetate under acidosis. Credit:Nature Cell Biology(2024). DOI: 10.1038/s41556-024-01372-4Like alien invade

Updated on:April 28,2024

Prostate cancer: Family history, genetics and your risk

by Jessica Saenz,Mayo ClinicCredit: Kampus Production from PexelsIf you've been diagnosed with prostate cancer, exploring what may have contributed to your cancer might not be at the top of

Updated on: November 10,2024

Prostate cancer: Family history, genetics and your risk

by Jessica Saenz,Mayo ClinicCredit: Kampus Production from PexelsIf you've been diagnosed with prostate cancer, exploring what may have contributed to your cancer might not be at the top of

Updated on:November 10,2024

As cancer treatment advances, patients and doctors push back against drugs' harsh side effects

by Carla K. JohnsonJill Feldman, 54, poses for a photo at her home in Deerfield, Ill., Friday, Jan. 19, 2024. Lung cancer patient and advocate Jill Feldman takes pills at home that shrink tumors by bl

Updated on: June 25,2024

As cancer treatment advances, patients and doctors push back against drugs' harsh side effects

by Carla K. JohnsonJill Feldman, 54, poses for a photo at her home in Deerfield, Ill., Friday, Jan. 19, 2024. Lung cancer patient and advocate Jill Feldman takes pills at home that shrink tumors by bl

Updated on:June 25,2024