The role of p53 as a target for novel cancer therapies

by Erika Rindsjö,Karolinska InstitutetComplex interplay between TP53-mutant cancer cells and their microenvironment. Credit:Nature Reviews Clinical Oncology(2023). DOI: 10.1038/s4157

Updated on: December 30,2023 16

The role of p53 as a target for novel cancer therapies

by Erika Rindsjö,Karolinska InstitutetComplex interplay between TP53-mutant cancer cells and their microenvironment. Credit:Nature Reviews Clinical Oncology(2023). DOI: 10.1038/s4157

Updated on:December 30,2023 16

Researchers target mutation that leads to pancreatic cancer

by Leslie Cantu,Medical University of South CarolinaCrystal structures of 12D5(K63S) in complex with KRAS(G12D)•GTPγS and with KRAS(G12D)•GDP. (A) A comparison of 12D5(K63S)–KRAS(G12D)•GTPγS (Le

Updated on: February 20,2024 20

Researchers target mutation that leads to pancreatic cancer

by Leslie Cantu,Medical University of South CarolinaCrystal structures of 12D5(K63S) in complex with KRAS(G12D)•GTPγS and with KRAS(G12D)•GDP. (A) A comparison of 12D5(K63S)–KRAS(G12D)•GTPγS (Le

Updated on:February 20,2024 20

Patients with HPV-positive oropharynx cancer should receive chemoradiation

byEuropean Society for Medical OncologyProf Hisham Mehanna, Chair, Head and Neck Surgery, Institute of Cancer and Genomic Sciences, University of Birmingham, UK, study author. Credit: © European

Updated on: December 18,2023 12

Patients with HPV-positive oropharynx cancer should receive chemoradiation

byEuropean Society for Medical OncologyProf Hisham Mehanna, Chair, Head and Neck Surgery, Institute of Cancer and Genomic Sciences, University of Birmingham, UK, study author. Credit: © European

Updated on:December 18,2023 12

New AI model detects 90% of lymphatic cancer cases

by Chalmers University of TechnologyCredit:The Lancet Digital Health(2023). DOI: 10.1016/S2589-7500(23)00203-0Medical image analysis using AI has developed rapidly in recent years. No

Updated on: March 20,2024 20

New AI model detects 90% of lymphatic cancer cases

by Chalmers University of TechnologyCredit:The Lancet Digital Health(2023). DOI: 10.1016/S2589-7500(23)00203-0Medical image analysis using AI has developed rapidly in recent years. No

Updated on:March 20,2024 20

Genetic discovery could improve treatment of colorectal cancer

by Rémi Carlier,Ecole Polytechnique Federale de LausannePOU5F1B differs from OCT4. a Representative immunofluorescence–confocal microscopy of POU5F1B-HA overexpressing SW480 cells, with DAPI in

Updated on: December 25,2023 10

Genetic discovery could improve treatment of colorectal cancer

by Rémi Carlier,Ecole Polytechnique Federale de LausannePOU5F1B differs from OCT4. a Representative immunofluorescence–confocal microscopy of POU5F1B-HA overexpressing SW480 cells, with DAPI in

Updated on:December 25,2023 10

U.S. cancer deaths decline overall, but prostate cancers make rebound

by Dennis ThompsonCancer deaths continue to decline, dropping 33% since 1991 and saving an estimated 3.8 million lives, according to the American Cancer Society's annual statistics report.But indi

Updated on: December 28,2023 10

U.S. cancer deaths decline overall, but prostate cancers make rebound

by Dennis ThompsonCancer deaths continue to decline, dropping 33% since 1991 and saving an estimated 3.8 million lives, according to the American Cancer Society's annual statistics report.But indi

Updated on:December 28,2023 10

Surgery first for colon cancer? Not so fast, according to new study

by National Comprehensive Cancer NetworkRadiologic response, TRG, and clinical T stage. (A) Radiologic response among patients with different clinical T stage; patients with cT2–3 disease were more li

Updated on: January 10,2024 9

Surgery first for colon cancer? Not so fast, according to new study

by National Comprehensive Cancer NetworkRadiologic response, TRG, and clinical T stage. (A) Radiologic response among patients with different clinical T stage; patients with cT2–3 disease were more li

Updated on:January 10,2024 9

Examining how gender inequalities worsen women's access to cancer prevention, detection and care

by LancetWomen, power, and cancer: a Lancet Commission highlights how, at all these intersections with cancer, women across the globe are subject to overlapping forms of discrimination and inequi

Updated on: February 20,2024 17

Examining how gender inequalities worsen women's access to cancer prevention, detection and care

by LancetWomen, power, and cancer: a Lancet Commission highlights how, at all these intersections with cancer, women across the globe are subject to overlapping forms of discrimination and inequi

Updated on:February 20,2024 17

Guideline updated for initial management of advanced prostate cancer

by Elana GotkineFor patients with noncastrate advanced prostate cancer, docetaxel, abiraterone, enzalutamide, apalutamide, or darolutamide are each recommended as standards of care with androgen depri

Updated on: January 08,2024 10

Guideline updated for initial management of advanced prostate cancer

by Elana GotkineFor patients with noncastrate advanced prostate cancer, docetaxel, abiraterone, enzalutamide, apalutamide, or darolutamide are each recommended as standards of care with androgen depri

Updated on:January 08,2024 10

Machine learning to identify cancer type-specific driver mutations for the development of new drug targets

by Pohang University of Science & Technology (POSTECH)Credit: POSTECHAccording to Statistics Korea, cancer is the top cause of death in 2021, accounting for 26% of deaths. Most cancer patients mis

Updated on: December 25,2023 8

Machine learning to identify cancer type-specific driver mutations for the development of new drug targets

by Pohang University of Science & Technology (POSTECH)Credit: POSTECHAccording to Statistics Korea, cancer is the top cause of death in 2021, accounting for 26% of deaths. Most cancer patients mis

Updated on:December 25,2023 8

Double testing better at identifying bowel cancer

byUniversity of EdinburghReceiver operating characteristic (ROC) curve analysis for the detection of colorectal cancer between cohorts. Area under the curve 0.85 (95% c.i. 0.80 to 0.90) for the

Updated on: January 04,2024 8

Double testing better at identifying bowel cancer

byUniversity of EdinburghReceiver operating characteristic (ROC) curve analysis for the detection of colorectal cancer between cohorts. Area under the curve 0.85 (95% c.i. 0.80 to 0.90) for the

Updated on:January 04,2024 8

Avelumab plus axitinib significantly improve progression-free survival in untreated renal cell carcinoma

byEuropean Society for Medical OncologyCredit: CC0 Public DomainA combination of the immune checkpoint blocker, avelumab, plus the tyrosine kinase inhibitor (TKI), axitinib, significantly improv

Updated on: December 18,2023 19

Avelumab plus axitinib significantly improve progression-free survival in untreated renal cell carcinoma

byEuropean Society for Medical OncologyCredit: CC0 Public DomainA combination of the immune checkpoint blocker, avelumab, plus the tyrosine kinase inhibitor (TKI), axitinib, significantly improv

Updated on:December 18,2023 19