Preventing 'identity theft' in prostate cancer cells re-sensitizes them to therapy

byUT Southwestern Medical CenterJAK–STAT signaling is required for Enz resistance in TP53/RB1-deficient mCRPC.a, Heat map representing the significantly changed signaling pathways in LNCaP

Updated on: December 22,2023

Preventing 'identity theft' in prostate cancer cells re-sensitizes them to therapy

byUT Southwestern Medical CenterJAK–STAT signaling is required for Enz resistance in TP53/RB1-deficient mCRPC.a, Heat map representing the significantly changed signaling pathways in LNCaP

Updated on:December 22,2023

Gene loss enhances metastasis and cancer progression

by Melissa Rohman,Northwestern UniversityAn in vivo genome-wide CRISPR-Cas9 KO screen identifying CTC-promoting genetic factors. (A) Experimental design of the genome-wide CRISPR-Cas9 KO screen

Updated on: December 25,2023

Gene loss enhances metastasis and cancer progression

by Melissa Rohman,Northwestern UniversityAn in vivo genome-wide CRISPR-Cas9 KO screen identifying CTC-promoting genetic factors. (A) Experimental design of the genome-wide CRISPR-Cas9 KO screen

Updated on:December 25,2023

How do we overcome treatment resistance in a sarcoma cancer with already limited treatment options?

by Elena Daviter-Nowell,Institute of Cancer ResearchHistopathology image of leiomyosarcoma. Credit:Wikimedia Commons, CC-BY-SA 4.0Leiomyosarcoma is a type of soft tissue sarcoma that is ha

Updated on: January 10,2024

How do we overcome treatment resistance in a sarcoma cancer with already limited treatment options?

by Elena Daviter-Nowell,Institute of Cancer ResearchHistopathology image of leiomyosarcoma. Credit:Wikimedia Commons, CC-BY-SA 4.0Leiomyosarcoma is a type of soft tissue sarcoma that is ha

Updated on:January 10,2024

Major pathologic response to neoadjuvant pembrolizumab in advanced melanoma trial exceeds 50%

by SWOG Cancer Research NetworkCredit: CC0 Public DomainIn exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major patholog

Updated on: April 22,2024

Major pathologic response to neoadjuvant pembrolizumab in advanced melanoma trial exceeds 50%

by SWOG Cancer Research NetworkCredit: CC0 Public DomainIn exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major patholog

Updated on:April 22,2024

Cancer test shows promise for bringing the benefits of immunotherapy to more patients

byBrigham and Women’s HospitalCredit: Pixabay/CC0 Public DomainImmunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identif

Updated on: January 25,2024

Cancer test shows promise for bringing the benefits of immunotherapy to more patients

byBrigham and Women’s HospitalCredit: Pixabay/CC0 Public DomainImmunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identif

Updated on:January 25,2024

National prostate cancer trial currently testing therapy based on molecular discovery

byCleveland ClinicCredit:Journal of Clinical Investigation(2023). DOI: 10.1172/JCI163498A new prostate cancer therapy in clinical trials could treat patients resistant to treatment t

Updated on: December 23,2023

National prostate cancer trial currently testing therapy based on molecular discovery

byCleveland ClinicCredit:Journal of Clinical Investigation(2023). DOI: 10.1172/JCI163498A new prostate cancer therapy in clinical trials could treat patients resistant to treatment t

Updated on:December 23,2023

Risks after treatment for cervical neoplasia have declined over time

by Karolinska InstitutetCredit: Pixabay/CC0 Public DomainThe treatment of serious prodromal cervical cancer, CIN3, can cause problems during later pregnancy amongst women of fertile age. A new re

Updated on: March 23,2024

Risks after treatment for cervical neoplasia have declined over time

by Karolinska InstitutetCredit: Pixabay/CC0 Public DomainThe treatment of serious prodromal cervical cancer, CIN3, can cause problems during later pregnancy amongst women of fertile age. A new re

Updated on:March 23,2024

Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma

by Impact Journals LLCRuxolitinib exerts its anti-myeloma effects through several mechanisms. Credit:Oncotarget(2024). DOI: 10.18632/oncotarget.28547A new research perspective titled &quot

Updated on: May 07,2024

Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma

by Impact Journals LLCRuxolitinib exerts its anti-myeloma effects through several mechanisms. Credit:Oncotarget(2024). DOI: 10.18632/oncotarget.28547A new research perspective titled &quot

Updated on:May 07,2024

CEACAMS 1, 5, and 6 in disease and cancer: Interactions with pathogens

by Impact Journals LLCSignaling of dimeric CEACAM1 long tail isoform in epithelial cells and T cells. Credit:Genes & Cancer(2023). DOI: 10.18632/genesandcancer.230A new review was rece

Updated on: December 25,2023

CEACAMS 1, 5, and 6 in disease and cancer: Interactions with pathogens

by Impact Journals LLCSignaling of dimeric CEACAM1 long tail isoform in epithelial cells and T cells. Credit:Genes & Cancer(2023). DOI: 10.18632/genesandcancer.230A new review was rece

Updated on:December 25,2023

Researchers develop priorities for interventions to address health disparities in lung nodule management

by Boston University School of MedicineCascade-of-care framework for identifying potential areas for intervention to reduce disparities in lung nodule evaluation. This figure shows each step of a

Updated on: February 20,2024

Researchers develop priorities for interventions to address health disparities in lung nodule management

by Boston University School of MedicineCascade-of-care framework for identifying potential areas for intervention to reduce disparities in lung nodule evaluation. This figure shows each step of a

Updated on:February 20,2024

Time for a 'Weed-Free January?' How cannabis users could benefit from a 'dry' month

by James MacKillop,The ConversationCredit: RDNE Stock project from PexelsBy now, most are familiar with the idea of Dry January, a voluntary month without alcohol that follows a month when many

Updated on: March 26,2024

Time for a 'Weed-Free January?' How cannabis users could benefit from a 'dry' month

by James MacKillop,The ConversationCredit: RDNE Stock project from PexelsBy now, most are familiar with the idea of Dry January, a voluntary month without alcohol that follows a month when many

Updated on:March 26,2024

Clinical trial shows durvalumab plus ceralasertib boosted immune response in lung cancer patients

by University of Texas M. D. Anderson Cancer CenterCredit: Unsplash/CC0 Public DomainA specific combination of targeted therapy and immunotherapy may better help patients with non-small cell lung

Updated on: May 09,2024

Clinical trial shows durvalumab plus ceralasertib boosted immune response in lung cancer patients

by University of Texas M. D. Anderson Cancer CenterCredit: Unsplash/CC0 Public DomainA specific combination of targeted therapy and immunotherapy may better help patients with non-small cell lung

Updated on:May 09,2024