by TranSpread

Credit: Eco-Environment & Health (2024). DOI: 10.1016/j.eehl.2024.04.008

Childhood obesity is a growing global public health concern, significantly increasing the risk of various health issues later in life. Factors contributing to obesity include genetic, socioeconomic, behavioral, and environmental influences.

Air pollution, particularly ozone exposure, has recently been identified as a potential risk factor for obesity and metabolic disorders. Based on these challenges, there is a need to conduct in-depth research on the effects of prenatal air pollution exposure on child development to better understand and mitigate these risks.

A recent study conducted by researchers from Fudan University and Zhengzhou University, published in Eco-Environment & Health, examined the impact of prenatal ozone exposure on childhood growth and obesity.

The study assessed ozone exposure during pregnancy using a high-resolution random forest model based on the Shanghai Maternal-Child Pairs Cohort. It provides critical insights into how increased prenatal ozone levels are associated with higher risks of accelerated growth and obesity in early childhood.

The study involved 4,909 maternal-child pairs from the Shanghai Maternal-Child Pairs Cohort. Researchers used a high-resolution random forest model to estimate prenatal ozone exposure based on the home addresses of pregnant women. Physical growth parameters of the children were measured at multiple time points during the first two years of life.

The study found that each 10 μg/m³ increase in prenatal ozone concentration was associated with significant increases in BMI-for-age Z score (BAZ), weight-for-age Z score (WAZ), and weight-for-length Z score (WLZ). Specifically, this exposure was linked to a 1.208-fold and 1.209-fold increase in the elevated-increasing group for BAZ and WLZ trajectories, respectively.

Moreover, prenatal ozone exposure was associated with a 1.355-fold increase in the risk of overweight and obesity (OAO) in children for the first two years of life. The findings suggest that prenatal ozone exposure can lead to accelerated BMI gain or decelerated body length gain in early childhood, increasing the risk of obesity.

Dr. Yunhui Zhang from School of Public Health at Fudan University, a corresponding author of the study, stated, "Our research highlights the significant impact of prenatal ozone exposure on early childhood growth and obesity. These findings underscore the importance of addressing air quality issues to protect the health and development of future generations."

该研究的结果强调需要严格的空气质量法规，以尽量减少产前暴露于臭氧。政策制定者和公共卫生官员应优先考虑减少空气污染的战略，特别是在臭氧水平高的城市地区。应让孕妇意识到臭氧暴露的潜在风险，并采取预防措施保护其健康和子女的发育。

Further research is needed to explore the underlying mechanisms and long-term health impacts of prenatal ozone exposure on children's growth and obesity.

More information: Xinyao Sui et al, Prenatal ozone exposure is associated with children overweight and obesity: Evidence from the Shanghai Maternal-Child Pairs Cohort, Eco-Environment & Health (2024). DOI: 10.1016/j.eehl.2024.04.008

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