1.Adiposity modifies the association between heart failure risk and glucose metabolic disorder in older individuals: a community-based prospective cohort study

DOI: 10.1186/s12933-024-02418-5

https://cardiab.biomedcentral.com/articles/10.1186/s12933-024-02418-5

Obesity is a comorbidity closely associated with glucose metabolism abnormalities in elderly individuals. However, the impact of obesity on the relationship between glucose metabolism disorders and the risk of heart failure (HF), as well as the underlying mechanisms, remains unclear. In this study, researchers analyzed data from 13,251 participants aged 60 and above, categorizing them into groups based on normal glucose levels, prediabetes, uncontrolled glucose, and well-controlled glucose. According to the results, 1,138 participants developed HF during an average follow-up period of 10.9 years. Compared to the normal glucose group, the incidence of HF was higher in the other groups, with participants having a higher waist-to-hip ratio showing an increased likelihood of developing HF. Based on the evidence presented in the article, obesity was found to attenuate the association between glucose metabolism disorders and the incidence of heart failure.

For more details, please refer to the original article.

2.Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia

DOI: 10.1001/jamanetworkopen.2024.29494

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822908

In Asia, the risk and mortality rate of colorectal cancer (CRC) are on the rise. This article presents a study based on data from multiple Asian countries, involving a total of 709,214 individuals. The data indicates a positive correlation between BMI and the incidence and mortality of CRC. The risk is particularly higher among male participants and those with colon cancer.

For more details, please refer to the original article.

3.Efficacy and safety of diacerein monotherapy in adults with obesity: A randomized, double-blind, placebo-controlled trial

DOI: 10.1111/dom.15881

https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.15881

Diacerein is a drug traditionally used to treat osteoarthritis, but some studies have suggested it may also be effective in treating obesity. This article presents a randomized, double-blind, placebo-controlled trial based on that hypothesis. The study included 42 adult participants with obesity who were randomly assigned in a double-blind manner to receive either diacerein or a placebo, along with lifestyle modifications, over a 14-week period. The results showed that the diacerein group experienced significant improvements in body composition, metabolic variables, and markers related to fatty liver. For obese adults, diacerein led to clinically meaningful weight loss and provided various metabolic benefits, with an acceptable safety profile.

For more detailed information, please refer to the original article.

4.Association Between Obesity and Risk of Total and Obesity-Related Cancer in People With Incident Cardiovascular Disease

DOI: 10.1161/JAHA.124.034438

https://www.ahajournals.org/doi/10.1161/JAHA.124.034438

Due to shared risk factors such as obesity, cardiovascular disease (CVD) and cancer frequently occur concurrently. This study investigates whether the combination of CVD and obesity further increases the risk of developing cancer. A total of 5,127 patients with newly diagnosed CVD were included in the research, among whom 1,511 developed a first primary cancer. The findings revealed that obese individuals with CVD had a higher incidence of cancer compared to those with normal weight. Notably, women with both CVD and obesity exhibited an increased risk of obesity-related cancers.

For more detailed information, please refer to the original article.

5.Symptoms of Depression, Eating Disorders, and Binge Eating in Adolescents With Obesity: The Fast Track to Health Randomized Clinical Trial

DOI: 10.1001/jamapediatrics.2024.2851

https://jamanetwork.com/journals/jamapediatrics/fullarticle/2822792

Adolescent mental health is a major societal concern, and teens struggling with obesity are particularly vulnerable to psychological issues, such as depression and eating disorders. This article presents a randomized clinical trial focused on the psychological problems faced by obese adolescents. The study included 141 participants, and the results indicated that many obese adolescents seeking treatment self-reported symptoms of depression and eating disorders. While most participants showed a reduction in these symptoms, some required additional support. The study suggests that the treatment of obesity presents a valuable opportunity for screening and monitoring depression and eating disorders.

For more detailed information, please refer to the original article.