Rogue immune cells linked to leukemia found to be a key driver of autoimmune diseases

by Garvan Institute of Medical ResearchA killer T cell (centre) hunting a target cell. Credit: NIH Image GalleryGene variants associated with leukemia can produce "rogue" immune cells t

Updated on: February 20,2024 11

Rogue immune cells linked to leukemia found to be a key driver of autoimmune diseases

by Garvan Institute of Medical ResearchA killer T cell (centre) hunting a target cell. Credit: NIH Image GalleryGene variants associated with leukemia can produce "rogue" immune cells t

Updated on:February 20,2024 11

Some breast cancer patients with high responses to chemotherapy may not need surgery

by University of Texas M. D. Anderson Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit:

Updated on: February 20,2024 12

Some breast cancer patients with high responses to chemotherapy may not need surgery

by University of Texas M. D. Anderson Cancer CenterThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit:

Updated on:February 20,2024 12

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on: February 20,2024 19

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on:February 20,2024 19

Researchers reveal key mechanism of natural killer cell dysfunction

by Liu Jia,Chinese Academy of SciencesIntratumoral NK cells lack abundant membrane protrusions. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01462-9A team has revealed the

Updated on: February 20,2024 15

Researchers reveal key mechanism of natural killer cell dysfunction

by Liu Jia,Chinese Academy of SciencesIntratumoral NK cells lack abundant membrane protrusions. Credit:Nature Immunology(2023). DOI: 10.1038/s41590-023-01462-9A team has revealed the

Updated on:February 20,2024 15

Research team develops novel strategy to suppress prostate cancer growth

by Aaron Nieto,Baylor College of MedicineProstate cancer cells. Credit: NIH Image GalleryFinding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Y

Updated on: February 20,2024 18

Research team develops novel strategy to suppress prostate cancer growth

by Aaron Nieto,Baylor College of MedicineProstate cancer cells. Credit: NIH Image GalleryFinding valuable therapeutic interventions for prostate cancer has long guided the research of Dr. Feng Y

Updated on:February 20,2024 18

COVID-19 booster vaccine doses strengthen immunity in blood cancer patients, shows study

by University of SouthamptonCredit: Pixabay/CC0 Public DomainResearch by the University of Southampton into the effectiveness of COVID-19 vaccines in people with lymphoma has shown that repeated

Updated on: February 20,2024 19

COVID-19 booster vaccine doses strengthen immunity in blood cancer patients, shows study

by University of SouthamptonCredit: Pixabay/CC0 Public DomainResearch by the University of Southampton into the effectiveness of COVID-19 vaccines in people with lymphoma has shown that repeated

Updated on:February 20,2024 19

Researchers target mutation that leads to pancreatic cancer

by Leslie Cantu,Medical University of South CarolinaCrystal structures of 12D5(K63S) in complex with KRAS(G12D)•GTPγS and with KRAS(G12D)•GDP. (A) A comparison of 12D5(K63S)–KRAS(G12D)•GTPγS (Le

Updated on: February 20,2024 20

Researchers target mutation that leads to pancreatic cancer

by Leslie Cantu,Medical University of South CarolinaCrystal structures of 12D5(K63S) in complex with KRAS(G12D)•GTPγS and with KRAS(G12D)•GDP. (A) A comparison of 12D5(K63S)–KRAS(G12D)•GTPγS (Le

Updated on:February 20,2024 20

Computational method used to directly measure tumors shows hypertranscription is ubiquitous across cancers

by Bob Yirka , Medical XpressOverview of RNA output analysis with RNAmp. (A) Hypertranscription occurs when cancer cells elevate their RNA output above normal cell levels (left). Upon RNA extraction f

Updated on: February 20,2024 19

Computational method used to directly measure tumors shows hypertranscription is ubiquitous across cancers

by Bob Yirka , Medical XpressOverview of RNA output analysis with RNAmp. (A) Hypertranscription occurs when cancer cells elevate their RNA output above normal cell levels (left). Upon RNA extraction f

Updated on:February 20,2024 19

Study maps alterations that make melanoma more severe, could lead to better therapies and diagnosis

by André Julião,FAPESPStudy design, resources and methodology. A major aim (steps 1–2) is the discovery and validation of genome-wide methylation alterations associated with the UV mutational si

Updated on: February 20,2024 11

Study maps alterations that make melanoma more severe, could lead to better therapies and diagnosis

by André Julião,FAPESPStudy design, resources and methodology. A major aim (steps 1–2) is the discovery and validation of genome-wide methylation alterations associated with the UV mutational si

Updated on:February 20,2024 11

Researchers find breast cancer protein that could predict chemotherapy sensitivity

by Hunter Medical Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for

Updated on: February 20,2024 14

Researchers find breast cancer protein that could predict chemotherapy sensitivity

by Hunter Medical Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for

Updated on:February 20,2024 14

Researchers uncover new clues to origins of the most common pediatric kidney cancer

by Children's Hospital Los AngelesSIX2+CITED1+ cells in hFK and WT have different transcriptional signatures. A,B) Periodic acid Schiff (PAS, left, whole image) and H&E (right, close-up i

Updated on: February 20,2024 17

Researchers uncover new clues to origins of the most common pediatric kidney cancer

by Children's Hospital Los AngelesSIX2+CITED1+ cells in hFK and WT have different transcriptional signatures. A,B) Periodic acid Schiff (PAS, left, whole image) and H&E (right, close-up i

Updated on:February 20,2024 17

A blood test that screens for multiple cancers at once promises to boost early detection

by Colin Pritchard,The ConversationDNA contains molecular patterns that indicate where in the body it came from. Credit:CNX OpenStax/Wikimedia Commons,CC BYDetecting cancer early bef

Updated on: February 20,2024 13

A blood test that screens for multiple cancers at once promises to boost early detection

by Colin Pritchard,The ConversationDNA contains molecular patterns that indicate where in the body it came from. Credit:CNX OpenStax/Wikimedia Commons,CC BYDetecting cancer early bef

Updated on:February 20,2024 13