Examining a potential second generation epigenetic therapy for advanced solid tumors

by Vall d'Hebron Institute of OncologyCredit: Unsplash/CC0 Public DomainPreliminary results of a first-in-human study show manageable toxicity and preliminary antitumor activity of a potential sec

Updated on: February 18,2024 13

Examining a potential second generation epigenetic therapy for advanced solid tumors

by Vall d'Hebron Institute of OncologyCredit: Unsplash/CC0 Public DomainPreliminary results of a first-in-human study show manageable toxicity and preliminary antitumor activity of a potential sec

Updated on:February 18,2024 13

Inhibitor shows lasting structural integrity and long terminal half-life in tumor tissue

by Vall d'Hebron Institute of OncologyLaura Soucek, co-Director of Preclinical and Translational Research at VHIO, Chief Executive Officer of Peptomyc, and an ICREA Research Professor. Credit: VHI

Updated on: February 18,2024 18

Inhibitor shows lasting structural integrity and long terminal half-life in tumor tissue

by Vall d'Hebron Institute of OncologyLaura Soucek, co-Director of Preclinical and Translational Research at VHIO, Chief Executive Officer of Peptomyc, and an ICREA Research Professor. Credit: VHI

Updated on:February 18,2024 18

Researchers discover how melanoma changes its environment to support metastasis

by Tel-Aviv UniversityCredit: Pixabay/CC0 Public DomainA new study conducted at Tel Aviv University and the Sheba Medical Center reveals how melanoma cancer cells affect their close environment t

Updated on: February 18,2024 14

Researchers discover how melanoma changes its environment to support metastasis

by Tel-Aviv UniversityCredit: Pixabay/CC0 Public DomainA new study conducted at Tel Aviv University and the Sheba Medical Center reveals how melanoma cancer cells affect their close environment t

Updated on:February 18,2024 14

Better adenoma detection using a molecular marker for fluorescent imaging

by Sarah E. Glass,Vanderbilt University(a)Representative white light and corresponding fluorescence colonoscopy images (static) of B6;129 mice bearing either colorectal adenomas or normal

Updated on: February 18,2024 17

Better adenoma detection using a molecular marker for fluorescent imaging

by Sarah E. Glass,Vanderbilt University(a)Representative white light and corresponding fluorescence colonoscopy images (static) of B6;129 mice bearing either colorectal adenomas or normal

Updated on:February 18,2024 17

Researchers identify protein that may protect the heart during certain cancer treatment regimens

by Jacqueline Mitchell,Beth Israel Deaconess Medical CenterCirculating Hpx is elevated in mice treated with Dox. (A) Dox-induced chronic cardiomyopathy model in mice. i.p., intraperitoneally. (B

Updated on: February 18,2024 18

Researchers identify protein that may protect the heart during certain cancer treatment regimens

by Jacqueline Mitchell,Beth Israel Deaconess Medical CenterCirculating Hpx is elevated in mice treated with Dox. (A) Dox-induced chronic cardiomyopathy model in mice. i.p., intraperitoneally. (B

Updated on:February 18,2024 18

Study identifies new gene that drives colon cancer

by The Mount Sinai HospitalRecurrently dysregulated super-enhancers in CRC patients.aStudy overview. Figure adapted from SMART Servier Medical Art, reproduced with permission, license

Updated on: February 18,2024 15

Study identifies new gene that drives colon cancer

by The Mount Sinai HospitalRecurrently dysregulated super-enhancers in CRC patients.aStudy overview. Figure adapted from SMART Servier Medical Art, reproduced with permission, license

Updated on:February 18,2024 15

Researchers report encouraging immunotherapy option for relapsed myeloma patients

by The Mount Sinai HospitalTreatment breakdown of the multiple myeloma patient cohort. (A) Flow chart showing that the initial retrospective query yielded 115 RRMM patients enrolled on a BiAb cli

Updated on: February 18,2024 14

Researchers report encouraging immunotherapy option for relapsed myeloma patients

by The Mount Sinai HospitalTreatment breakdown of the multiple myeloma patient cohort. (A) Flow chart showing that the initial retrospective query yielded 115 RRMM patients enrolled on a BiAb cli

Updated on:February 18,2024 14

Research identifies new target that may prevent blood cancer

by Bill Snyder,Vanderbilt University Medical CenterCredit: Unsplash/CC0 Public DomainAn international coalition of biomedical researchers co-led by Alexander Bick, MD, Ph.D., at Vanderbilt Unive

Updated on: February 18,2024 14

Research identifies new target that may prevent blood cancer

by Bill Snyder,Vanderbilt University Medical CenterCredit: Unsplash/CC0 Public DomainAn international coalition of biomedical researchers co-led by Alexander Bick, MD, Ph.D., at Vanderbilt Unive

Updated on:February 18,2024 14

A CAR T cell therapy for advanced ovarian cancer developed

by City of Hope National Medical CenterMembrane-bound IL-12 engineered TAG72-CAR T cells induce higher IFNγ, T-cell expansion, and anti-tumor activity in vitro.a–cTumor cell killing o

Updated on: February 18,2024 10

A CAR T cell therapy for advanced ovarian cancer developed

by City of Hope National Medical CenterMembrane-bound IL-12 engineered TAG72-CAR T cells induce higher IFNγ, T-cell expansion, and anti-tumor activity in vitro.a–cTumor cell killing o

Updated on:February 18,2024 10

'Collateral damage' from normal cell function may cause mutations that play a role in cancer

by Wellcome Trust Sanger InstituteSpatial distribution of APOBEC-positive crypts. APOBEC-positive crypts and their surrounding crypts before microdissection with their SBS mutational spectrums. S

Updated on: February 18,2024 12

'Collateral damage' from normal cell function may cause mutations that play a role in cancer

by Wellcome Trust Sanger InstituteSpatial distribution of APOBEC-positive crypts. APOBEC-positive crypts and their surrounding crypts before microdissection with their SBS mutational spectrums. S

Updated on:February 18,2024 12

Researchers uncover racial and ethnic disparities in a widely used precision oncology data registry

by Katie Marquedant,Massachusetts General HospitalSample size estimation to detect differences in mutational proportions between white and racial/ethnic minority patients at varying power increm

Updated on: February 18,2024 16

Researchers uncover racial and ethnic disparities in a widely used precision oncology data registry

by Katie Marquedant,Massachusetts General HospitalSample size estimation to detect differences in mutational proportions between white and racial/ethnic minority patients at varying power increm

Updated on:February 18,2024 16

Long-term exposure to nitrates in drinking water may be a risk factor for prostate cancer

by Barcelona Institute for Global HealthCredit: Pixabay/CC0 Public DomainThe nitrate ingested over the course of a person's adult lifetime through the consumption of tap water and bottled wat

Updated on: February 18,2024 16

Long-term exposure to nitrates in drinking water may be a risk factor for prostate cancer

by Barcelona Institute for Global HealthCredit: Pixabay/CC0 Public DomainThe nitrate ingested over the course of a person's adult lifetime through the consumption of tap water and bottled wat

Updated on:February 18,2024 16