Researchers generate lab-grown human tissue model for food tube cancer

by Johns Hopkins University School of MedicineHuman gastroesophageal junction-derived organoid, modified by dual-knockout of key tumor suppressor genes (TP53/CDKN2A) using CRISPR/Cas9 gene editin

Updated on: February 03,2024 17

Researchers generate lab-grown human tissue model for food tube cancer

by Johns Hopkins University School of MedicineHuman gastroesophageal junction-derived organoid, modified by dual-knockout of key tumor suppressor genes (TP53/CDKN2A) using CRISPR/Cas9 gene editin

Updated on:February 03,2024 17

Researchers identify drug characteristics that make cancer metastasis therapy more effective

by Tohoku UniversityOptimal osmotic pressure and viscosity ranges for anticancer drug solvents used in lymphatic delivery (blue area). It is applicable to all types of cancer. Credit: Tohoku Univ

Updated on: February 03,2024 20

Researchers identify drug characteristics that make cancer metastasis therapy more effective

by Tohoku UniversityOptimal osmotic pressure and viscosity ranges for anticancer drug solvents used in lymphatic delivery (blue area). It is applicable to all types of cancer. Credit: Tohoku Univ

Updated on:February 03,2024 20

Investigators find disparities in mesothelioma survival due to social determinants, limited access

by Sylvester Comprehensive Cancer CenterCredit: Pixabay/CC0 Public DomainTreatment outcomes for patients with malignant pleural mesothelioma, a rare cancer commonly known as mesothelioma, are often af

Updated on: February 03,2024 18

Investigators find disparities in mesothelioma survival due to social determinants, limited access

by Sylvester Comprehensive Cancer CenterCredit: Pixabay/CC0 Public DomainTreatment outcomes for patients with malignant pleural mesothelioma, a rare cancer commonly known as mesothelioma, are often af

Updated on:February 03,2024 18

Researchers overcome treatment resistance mechanism in one of the most aggressive types of breast cancer

by IMIM (Hospital del Mar Medical Research Institute)Stromal traits define resistance to trastuzumab.aPercentage of CD45+ cells in HER2+ BC tumors comparing relapse-free (blue) to relapsin

Updated on: February 03,2024 16

Researchers overcome treatment resistance mechanism in one of the most aggressive types of breast cancer

by IMIM (Hospital del Mar Medical Research Institute)Stromal traits define resistance to trastuzumab.aPercentage of CD45+ cells in HER2+ BC tumors comparing relapse-free (blue) to relapsin

Updated on:February 03,2024 16

Chemotherapy-resistant ovarian cancer cells protect their neighbors, shows study

by University of PittsburghCredit: Unsplash/CC0 Public DomainCertain chemotherapy-resistant ovarian cancer cells protect neighboring cancer cells by sending signals that induce resistance, accord

Updated on: February 03,2024 13

Chemotherapy-resistant ovarian cancer cells protect their neighbors, shows study

by University of PittsburghCredit: Unsplash/CC0 Public DomainCertain chemotherapy-resistant ovarian cancer cells protect neighboring cancer cells by sending signals that induce resistance, accord

Updated on:February 03,2024 13

Using donor CAR T cells shows promise in treating myeloma patients in phase I trial

by Bob Yirka , Medical XpressCAR T Cell Concentrations Stratified by Response. (a) CAR T cell concentrations among ALLO-715 DL3 patients that received any fludarabine/cyclophosphamide/ALLO-647 (FCA) l

Updated on: February 03,2024 20

Using donor CAR T cells shows promise in treating myeloma patients in phase I trial

by Bob Yirka , Medical XpressCAR T Cell Concentrations Stratified by Response. (a) CAR T cell concentrations among ALLO-715 DL3 patients that received any fludarabine/cyclophosphamide/ALLO-647 (FCA) l

Updated on:February 03,2024 20

Study identifies new therapeutic target for tumor treatment

by Olivia Dimmer,Northwestern UniversityIntratumoral Tregcells have increased mRNA expression ofUsp22andUsp21.(AtoC) mRNA level of YFP+sorted Treg

Updated on: February 03,2024 12

Study identifies new therapeutic target for tumor treatment

by Olivia Dimmer,Northwestern UniversityIntratumoral Tregcells have increased mRNA expression ofUsp22andUsp21.(AtoC) mRNA level of YFP+sorted Treg

Updated on:February 03,2024 12

Study finds senescent immune cells promote lung tumor growth

by Mayo ClinicGraphical abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.05.006Macrophages are a type of white blood cell that are among the body's first line of defe

Updated on: February 03,2024 19

Study finds senescent immune cells promote lung tumor growth

by Mayo ClinicGraphical abstract. Credit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.05.006Macrophages are a type of white blood cell that are among the body's first line of defe

Updated on:February 03,2024 19

Treatment with immunotherapy alone produces 'exceptional' response rates in some melanoma patients

by Ohio State University Medical CenterMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0Data from a national clinic

Updated on: February 03,2024 14

Treatment with immunotherapy alone produces 'exceptional' response rates in some melanoma patients

by Ohio State University Medical CenterMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0Data from a national clinic

Updated on:February 03,2024 14

Researchers revisit potent drug as promising treatment for acute leukemia

by National University of SingaporeChemical screening using the GIMAP enhancer reporter system. (A) Overview of the chemical screening strategy. Using a liquid handling workstation, 2,961 compoun

Updated on: February 03,2024 11

Researchers revisit potent drug as promising treatment for acute leukemia

by National University of SingaporeChemical screening using the GIMAP enhancer reporter system. (A) Overview of the chemical screening strategy. Using a liquid handling workstation, 2,961 compoun

Updated on:February 03,2024 11

Team discovers broken 'brake' of cancer mutation machine

by UT Southwestern Medical CenterCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.06.010Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that

Updated on: February 03,2024 15

Team discovers broken 'brake' of cancer mutation machine

by UT Southwestern Medical CenterCredit:Cancer Cell(2023). DOI: 10.1016/j.ccell.2023.06.010Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that

Updated on:February 03,2024 15

Study validates clinical utility of pan-tumor predictive biomarker for checkpoint inhibitor immunotherapy benefit

by Strata OncologyDevelopment of an integrative immunotherapy response score (IRS) model to stratify PD-(L)1 therapy benefit in patients with advanced solid tumors.aReal-world treatment an

Updated on: February 03,2024 19

Study validates clinical utility of pan-tumor predictive biomarker for checkpoint inhibitor immunotherapy benefit

by Strata OncologyDevelopment of an integrative immunotherapy response score (IRS) model to stratify PD-(L)1 therapy benefit in patients with advanced solid tumors.aReal-world treatment an

Updated on:February 03,2024 19