New review on p53 biology and reactivation in blood cancers

byKarolinska InstitutetA simplified scheme of p53 regulation in cells upon stress and the drugs currently evaluated in clinical trials for p53 reactivation for improved therapy in MDS and AML. C

Updated on: March 30,2024

New review on p53 biology and reactivation in blood cancers

byKarolinska InstitutetA simplified scheme of p53 regulation in cells upon stress and the drugs currently evaluated in clinical trials for p53 reactivation for improved therapy in MDS and AML. C

Updated on:March 30,2024

Neuronal molecule makes prostate cancer more aggressive

byThomas Jefferson UniversityCredit: Unsplash/CC0 Public DomainProstate cancer is the second most common cancer and the second leading cause of cancer death among American men. Now, researchers

Updated on: January 04,2024

Neuronal molecule makes prostate cancer more aggressive

byThomas Jefferson UniversityCredit: Unsplash/CC0 Public DomainProstate cancer is the second most common cancer and the second leading cause of cancer death among American men. Now, researchers

Updated on:January 04,2024

Research team reveals mechanisms at work in progression of pancreatic cysts to pancreatic cancer

by University of California, San FranciscoPancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstitutePancreatic cysts have gained substantial

Updated on: January 30,2024

Research team reveals mechanisms at work in progression of pancreatic cysts to pancreatic cancer

by University of California, San FranciscoPancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstitutePancreatic cysts have gained substantial

Updated on:January 30,2024

Stress granules may drive obesity-associated pancreatic cancer

byThomas Jefferson UniversityCredit: Pixabay/CC0 Public DomainObesity is a known risk factor for at least13 types of cancer, in part because it creates ever-present inflammatory state. For

Updated on: January 16,2024

Stress granules may drive obesity-associated pancreatic cancer

byThomas Jefferson UniversityCredit: Pixabay/CC0 Public DomainObesity is a known risk factor for at least13 types of cancer, in part because it creates ever-present inflammatory state. For

Updated on:January 16,2024

A novel network computer model to find co-occurring mutations—researchers improve search for cancer drivers

by Tina Hilding,Washington State UniversityNumber of mutations by variant type (A) before filtering and (B) after filtering. (C) Number of genes and their role in cancer. (D) Pie chart showing t

Updated on: September 28,2024

A novel network computer model to find co-occurring mutations—researchers improve search for cancer drivers

by Tina Hilding,Washington State UniversityNumber of mutations by variant type (A) before filtering and (B) after filtering. (C) Number of genes and their role in cancer. (D) Pie chart showing t

Updated on:September 28,2024

Exercise testing detects silent cardiovascular dangers common in pediatric cancer survivors

by Nemours Children's Health SystemCredit: Pixabay/CC0 Public DomainCardiopulmonary exercise testing (CPET) can detect underlying early signs of cardiovascular problems in asymptomatic pediat

Updated on: February 18,2024

Exercise testing detects silent cardiovascular dangers common in pediatric cancer survivors

by Nemours Children's Health SystemCredit: Pixabay/CC0 Public DomainCardiopulmonary exercise testing (CPET) can detect underlying early signs of cardiovascular problems in asymptomatic pediat

Updated on:February 18,2024

Long exposure to protein inhibitor may be key to more effective chemotherapy for cancer

by Southern Methodist UniversityLong exposure to P-gp inhibitor and chemotherapy decreased cancer cell survival, as assessed by colony formation. Credit: SMUResearchers at SMU's Center for Dr

Updated on: April 18,2024

Long exposure to protein inhibitor may be key to more effective chemotherapy for cancer

by Southern Methodist UniversityLong exposure to P-gp inhibitor and chemotherapy decreased cancer cell survival, as assessed by colony formation. Credit: SMUResearchers at SMU's Center for Dr

Updated on:April 18,2024

Factors predict low BMD in pediatric blood cancer survivors

Low bone mineral density (BMD) is common in childhood leukemia and lymphoma survivors, according to a study published online Sept. 19 inCancer.Hadley M. Bloomhardt, M.D., from the Yale School of

Updated on: May 11,2024

Factors predict low BMD in pediatric blood cancer survivors

Low bone mineral density (BMD) is common in childhood leukemia and lymphoma survivors, according to a study published online Sept. 19 inCancer.Hadley M. Bloomhardt, M.D., from the Yale School of

Updated on:May 11,2024

Study identifies new treatment target for metastatic cancer

by Elizabeth Chapin,University of KentuckySuccinate levels are elevated during EMT. (A) Expression of EMT markers was assessed by western blot in control, Snail1- and Twist1-expressing HMLE cell

Updated on: February 18,2024

Study identifies new treatment target for metastatic cancer

by Elizabeth Chapin,University of KentuckySuccinate levels are elevated during EMT. (A) Expression of EMT markers was assessed by western blot in control, Snail1- and Twist1-expressing HMLE cell

Updated on:February 18,2024

Research raises hopes for new treatment of fusion-driven cancer

by Aarhus UniversityFusion-gene disruption strategy.ADual intron-targeting CRISPR-Cas9-mediated disruption ofRUNX1-RUNX1T1. sgRNAs targeting intron 4 ofRUNX1(orange)

Updated on: February 03,2024

Research raises hopes for new treatment of fusion-driven cancer

by Aarhus UniversityFusion-gene disruption strategy.ADual intron-targeting CRISPR-Cas9-mediated disruption ofRUNX1-RUNX1T1. sgRNAs targeting intron 4 ofRUNX1(orange)

Updated on:February 03,2024

Working toward personalized cancer treatment

by Weizmann Institute of ScienceProf. Yardena Samuels wants to reveal the big cancer picture. Credit: Weizmann Institute of Science"We don't just want to find the genes involved in cance

Updated on: April 09,2024

Working toward personalized cancer treatment

by Weizmann Institute of ScienceProf. Yardena Samuels wants to reveal the big cancer picture. Credit: Weizmann Institute of Science"We don't just want to find the genes involved in cance

Updated on:April 09,2024

Study: B cells promote liver cancer with dangerous dual strategy

byGerman Cancer Research CenterGraphical Abstract. Credit:Journal of Hepatology(2023). DOI: 10.1016/j.jhep.2023.04.037Inflammatory fatty liver disease (NASH, non alcoholic steatohepa

Updated on: January 16,2024

Study: B cells promote liver cancer with dangerous dual strategy

byGerman Cancer Research CenterGraphical Abstract. Credit:Journal of Hepatology(2023). DOI: 10.1016/j.jhep.2023.04.037Inflammatory fatty liver disease (NASH, non alcoholic steatohepa

Updated on:January 16,2024