Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on: March 01,2024

Study shows why a common form of immunotherapy fails, and suggests solution

by Georgetown University Medical CenterSamir N. Khleif, MD, director of The Loop Immuno-Oncology Laboratory at Georgetown Lombardi, led the research team that published new research on checkpoint

Updated on:March 01,2024

Drug turns cancer gene into 'eat me' flag for immune system

by Robin Marks,University of California, San FranciscoMicroscopy of a lung tumor biopsy. Credit: Lin MaTumor cells are notoriously good at evading the human immune system; they put up physical w

Updated on: February 24,2024

Drug turns cancer gene into 'eat me' flag for immune system

by Robin Marks,University of California, San FranciscoMicroscopy of a lung tumor biopsy. Credit: Lin MaTumor cells are notoriously good at evading the human immune system; they put up physical w

Updated on:February 24,2024

Poor oral health linked to a 75% increase in liver cancer risk, new study finds

by SAGE PublicationsCredit: CC0 Public DomainThe study, by researchers at Queen's University Belfast, analysed a large cohort of over 469,000 people in the UK, investigated the association be

Updated on: May 21,2024

Poor oral health linked to a 75% increase in liver cancer risk, new study finds

by SAGE PublicationsCredit: CC0 Public DomainThe study, by researchers at Queen's University Belfast, analysed a large cohort of over 469,000 people in the UK, investigated the association be

Updated on:May 21,2024

New study reveals an unexpected survival mechanism of a subset of cancer cells

by Instituto de Medicina MolecularMetaphase chromosomes from ALT cancer cells (U2OS osteosarcoma cell line) depleted for FANCM. Telomeric DNA is in green, chromosomal DNA is in red. The arrowheads poi

Updated on: May 21,2024

New study reveals an unexpected survival mechanism of a subset of cancer cells

by Instituto de Medicina MolecularMetaphase chromosomes from ALT cancer cells (U2OS osteosarcoma cell line) depleted for FANCM. Telomeric DNA is in green, chromosomal DNA is in red. The arrowheads poi

Updated on:May 21,2024

Tumor-specific therapy targets ovarian cancer

by Anna Zarra Aldrich,University of ConnecticutUConn professor Xiuling Lu with members of her lab team at the School of Pharmacy on Nov. 8, 2018. Credit: (Sean Flynn/UConn Photo)Nami Therapeutic

Updated on: April 09,2024

Tumor-specific therapy targets ovarian cancer

by Anna Zarra Aldrich,University of ConnecticutUConn professor Xiuling Lu with members of her lab team at the School of Pharmacy on Nov. 8, 2018. Credit: (Sean Flynn/UConn Photo)Nami Therapeutic

Updated on:April 09,2024

Epigenetic age and lung cancer risk in a prospective cohort study

by Impact Journals LLCCredit: Pixabay/CC0 Public DomainEpigenetic age, a robust marker of biological aging, has been associated with obesity, low-grade inflammation and metabolic diseases. However, fe

Updated on: February 03,2024

Epigenetic age and lung cancer risk in a prospective cohort study

by Impact Journals LLCCredit: Pixabay/CC0 Public DomainEpigenetic age, a robust marker of biological aging, has been associated with obesity, low-grade inflammation and metabolic diseases. However, fe

Updated on:February 03,2024

Researchers develop tool that reduces errors in stem cell transplant reporting

by Children's Hospital of PhiladelphiaCredit: CC0 Public DomainResearchers at Children's Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determinatio

Updated on: February 20,2024

Researchers develop tool that reduces errors in stem cell transplant reporting

by Children's Hospital of PhiladelphiaCredit: CC0 Public DomainResearchers at Children's Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determinatio

Updated on:February 20,2024

Researchers uncover new targets for breast cancers resistant to standard therapies

by Leslie Cantu,Medical University of South CarolinaSOC therapy commonly induces DNA damage, BRCAness and toxic PARP1 trapping, leading to transcriptional blockage and growth inhibition in ER+ b

Updated on: June 22,2024

Researchers uncover new targets for breast cancers resistant to standard therapies

by Leslie Cantu,Medical University of South CarolinaSOC therapy commonly induces DNA damage, BRCAness and toxic PARP1 trapping, leading to transcriptional blockage and growth inhibition in ER+ b

Updated on:June 22,2024

Reconsidering oxygen's role in growth of tumors

byYale UniversityGraphical abstract. Credit:Cell Systems(2022). DOI: 10.1016/j.cels.2022.11.003Yale researchers have made a discovery that changes conventional thinking about the rol

Updated on: January 22,2024

Reconsidering oxygen's role in growth of tumors

byYale UniversityGraphical abstract. Credit:Cell Systems(2022). DOI: 10.1016/j.cels.2022.11.003Yale researchers have made a discovery that changes conventional thinking about the rol

Updated on:January 22,2024

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer

byVall d'Hebron Institute of OncologyTreatment with BRAF inhibitors reduces tumor cell proliferation in subcutaneous BRAFV600EPMP-PDX tumors without impacting in apoptosis. a–d) Mice b

Updated on: August 03,2024

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer

byVall d'Hebron Institute of OncologyTreatment with BRAF inhibitors reduces tumor cell proliferation in subcutaneous BRAFV600EPMP-PDX tumors without impacting in apoptosis. a–d) Mice b

Updated on:August 03,2024

Discovery paves way for precision medicine in future

by University of OtagoThis high-dimensional analysis reveals the T cell signature in people with bowel cancer. The new analysis groups cells together so all cells can be viewed at once. In the pa

Updated on: April 18,2024

Discovery paves way for precision medicine in future

by University of OtagoThis high-dimensional analysis reveals the T cell signature in people with bowel cancer. The new analysis groups cells together so all cells can be viewed at once. In the pa

Updated on:April 18,2024

Drug bypasses suppressive immune cells to unleash immunotherapy

by Marta Wegorzewska,Washington University School of MedicineImmunobiologists Robert Schreiber, Ph.D., (left) and Hussein Sultan, Ph.D., of Washington University School of Medicine in St. Louis,

Updated on: August 28,2024

Drug bypasses suppressive immune cells to unleash immunotherapy

by Marta Wegorzewska,Washington University School of MedicineImmunobiologists Robert Schreiber, Ph.D., (left) and Hussein Sultan, Ph.D., of Washington University School of Medicine in St. Louis,

Updated on:August 28,2024