Subtyping of breast cancer cell lines reveals insights into cancer-relevant genes

by Manuela Schüngel, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbHWaterfall plot depicting recurrent non-synonymous mutations in BC cell lines. Mutations were calle

Updated on: March 30,2024

Subtyping of breast cancer cell lines reveals insights into cancer-relevant genes

by Manuela Schüngel, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbHWaterfall plot depicting recurrent non-synonymous mutations in BC cell lines. Mutations were calle

Updated on:March 30,2024

Drug compound could be next-generation treatment for aggressive form of leukemia

by Tom Coyne,Purdue UniversityHerman Sintim, the Drug Discovery Professor of Chemistry in Purdue University's Department of Chemistry, is leading a team of researchers developing a series of

Updated on: May 25,2024

Drug compound could be next-generation treatment for aggressive form of leukemia

by Tom Coyne,Purdue UniversityHerman Sintim, the Drug Discovery Professor of Chemistry in Purdue University's Department of Chemistry, is leading a team of researchers developing a series of

Updated on:May 25,2024

Polyploidy study reveals why some cancers are resistant to therapeutic drugs

byOsaka UniversityOverview of the study. (A) We created unique cells with double the usual number of chromosomes to investigate the relationship between polyploidy and DNA damage. (B) After trea

Updated on: November 09,2024

Polyploidy study reveals why some cancers are resistant to therapeutic drugs

byOsaka UniversityOverview of the study. (A) We created unique cells with double the usual number of chromosomes to investigate the relationship between polyploidy and DNA damage. (B) After trea

Updated on:November 09,2024

Reconsidering oxygen's role in growth of tumors

byYale UniversityGraphical abstract. Credit:Cell Systems(2022). DOI: 10.1016/j.cels.2022.11.003Yale researchers have made a discovery that changes conventional thinking about the rol

Updated on: January 22,2024

Reconsidering oxygen's role in growth of tumors

byYale UniversityGraphical abstract. Credit:Cell Systems(2022). DOI: 10.1016/j.cels.2022.11.003Yale researchers have made a discovery that changes conventional thinking about the rol

Updated on:January 22,2024

Prostate cancer: Can AI help to avoid unnecessary biopsies?

byGerman Cancer Research CenterRisk stratification example from the test cohort: a 66-year-old male presents with negative DRE, PSA elevation to 6.2 ng/mL, prostate volume of 82.5 mL, and PSAD o

Updated on: August 27,2024

Prostate cancer: Can AI help to avoid unnecessary biopsies?

byGerman Cancer Research CenterRisk stratification example from the test cohort: a 66-year-old male presents with negative DRE, PSA elevation to 6.2 ng/mL, prostate volume of 82.5 mL, and PSAD o

Updated on:August 27,2024

Repurposing existing FDA-approved inhibitors may provide new treatment approach for ovarian cancer

by The Wistar InstituteCredit: The Wistar InstituteWistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for t

Updated on: April 07,2024

Repurposing existing FDA-approved inhibitors may provide new treatment approach for ovarian cancer

by The Wistar InstituteCredit: The Wistar InstituteWistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for t

Updated on:April 07,2024

Discovery could lead to new drugs to block protein that fuels bowel cancer

by Institute of Cancer ResearchUsing cryo-electron microscopy, researchers obtained a detailed map (shown in orange) of the chain-like tankyrase structure. By interpreting this map and reconstruc

Updated on: February 23,2024

Discovery could lead to new drugs to block protein that fuels bowel cancer

by Institute of Cancer ResearchUsing cryo-electron microscopy, researchers obtained a detailed map (shown in orange) of the chain-like tankyrase structure. By interpreting this map and reconstruc

Updated on:February 23,2024

Study of immune 'neighborhoods' highlights macrophages as key players in invasive breast cancers

byUniversity of PittsburghCredit: Unsplash/CC0 Public DomainMost immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer. Targ

Updated on: January 02,2024

Study of immune 'neighborhoods' highlights macrophages as key players in invasive breast cancers

byUniversity of PittsburghCredit: Unsplash/CC0 Public DomainMost immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer. Targ

Updated on:January 02,2024

AI predicts cancer patients' symptoms

by University of SurreyCredit: CC0 Public DomainDoctors could get a head start treating cancer thanks to new AI developed at the University of Surrey that is able to predict symptoms and their se

Updated on: March 06,2024

AI predicts cancer patients' symptoms

by University of SurreyCredit: CC0 Public DomainDoctors could get a head start treating cancer thanks to new AI developed at the University of Surrey that is able to predict symptoms and their se

Updated on:March 06,2024

Reprogramming of immune cells shown to fight off melanoma

byUniversity of BristolmiR223 inhibition reduces cancer progression in zebrafish. A) Pigmentation of the tailfin quantified by threshold analysis of tail region (red dotted outline) in 1-month-o

Updated on: January 02,2024

Reprogramming of immune cells shown to fight off melanoma

byUniversity of BristolmiR223 inhibition reduces cancer progression in zebrafish. A) Pigmentation of the tailfin quantified by threshold analysis of tail region (red dotted outline) in 1-month-o

Updated on:January 02,2024

Boosting T cell 'memory' may result in longer-lasting and effective responses for patients

by University of Texas M. D. Anderson Cancer CenterScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDJust like pe

Updated on: April 18,2024

Boosting T cell 'memory' may result in longer-lasting and effective responses for patients

by University of Texas M. D. Anderson Cancer CenterScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDJust like pe

Updated on:April 18,2024

Researcher explores new treatment for advanced biliary tract cancers

by Blair Willis,University of ArizonaCredit: CC0 Public DomainA new treatment that may extend survival for patients with advanced biliary tract cancers—who typically face a grim outlook with ave

Updated on: June 06,2024

Researcher explores new treatment for advanced biliary tract cancers

by Blair Willis,University of ArizonaCredit: CC0 Public DomainA new treatment that may extend survival for patients with advanced biliary tract cancers—who typically face a grim outlook with ave

Updated on:June 06,2024