New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on: April 23,2024

New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration

by Jelena Pupavac,Wellcome Trust Sanger InstituteA single-cell base editor screen tiling acrossJAK1is improved by coupling genotype with transcriptome.aUMAP of LoF and no

Updated on:April 23,2024

New molecular blocker halts breast cancer metastasis, says study

byBar-Ilan UniversityA cell-permeable peptide derived from the second proline-rich region of Pyk2 blocks spontaneous lung metastasis in an immune-competent xenograft mouse model. Credit:On

Updated on: January 16,2024

New molecular blocker halts breast cancer metastasis, says study

byBar-Ilan UniversityA cell-permeable peptide derived from the second proline-rich region of Pyk2 blocks spontaneous lung metastasis in an immune-competent xenograft mouse model. Credit:On

Updated on:January 16,2024

'Promising' antibody therapy extends survival in mice with pancreatic cancer

by Pancreatic Cancer Research FundAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainScientists have found a way to target and knock out a singl

Updated on: May 07,2024

'Promising' antibody therapy extends survival in mice with pancreatic cancer

by Pancreatic Cancer Research FundAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainScientists have found a way to target and knock out a singl

Updated on:May 07,2024

Immune targets for chemotherapy-resistant breast cancers identified

byKing's College LondonAnalysis of stromal TILs in residual disease and prognostic implications. A) Kaplan–Meier curves for i) progression free survival and ii) overall survival in ER+HER2-

Updated on: January 02,2024

Immune targets for chemotherapy-resistant breast cancers identified

byKing's College LondonAnalysis of stromal TILs in residual disease and prognostic implications. A) Kaplan–Meier curves for i) progression free survival and ii) overall survival in ER+HER2-

Updated on:January 02,2024

Second primary malignancy risk increased after cutaneous B-cell lymphoma

by Elana GotkinePatients with primary cutaneous B-cell lymphomas (PCBCLs) have an increased risk for second primary malignancies (SPMs), according to a studypublishedonline March 19 in the

Updated on: April 06,2024

Second primary malignancy risk increased after cutaneous B-cell lymphoma

by Elana GotkinePatients with primary cutaneous B-cell lymphomas (PCBCLs) have an increased risk for second primary malignancies (SPMs), according to a studypublishedonline March 19 in the

Updated on:April 06,2024

Researchers develop novel photo-oxidation therapy for anticancer treatment

by City University of Hong KongThe CityU team developed a new class of near-infrared-activated platinum(IV) photo-oxidants that can effectively eliminate cancer cells in an oxygen-independent man

Updated on: June 08,2024

Researchers develop novel photo-oxidation therapy for anticancer treatment

by City University of Hong KongThe CityU team developed a new class of near-infrared-activated platinum(IV) photo-oxidants that can effectively eliminate cancer cells in an oxygen-independent man

Updated on:June 08,2024

Discovery paves way for precision medicine in future

by University of OtagoThis high-dimensional analysis reveals the T cell signature in people with bowel cancer. The new analysis groups cells together so all cells can be viewed at once. In the pa

Updated on: April 18,2024

Discovery paves way for precision medicine in future

by University of OtagoThis high-dimensional analysis reveals the T cell signature in people with bowel cancer. The new analysis groups cells together so all cells can be viewed at once. In the pa

Updated on:April 18,2024

Study could explain link between high-cholesterol diet and colon cancer

by University of California, Los AngelesA pale-blue stain shows stem cells multiplying in a mouse's intestine. Credit: Tontonoz lab/UCLANew UCLA research could help explain the link between a

Updated on: June 28,2024

Study could explain link between high-cholesterol diet and colon cancer

by University of California, Los AngelesA pale-blue stain shows stem cells multiplying in a mouse's intestine. Credit: Tontonoz lab/UCLANew UCLA research could help explain the link between a

Updated on:June 28,2024

Gut bacteria engineered to act as tumor GPS for immunotherapies

byDana-Farber Cancer InstituteBacteria displaying hDR18 enhance anti-tumor responses of MSLN-CAR NK cells. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02418-6Immunothe

Updated on: October 10,2024

Gut bacteria engineered to act as tumor GPS for immunotherapies

byDana-Farber Cancer InstituteBacteria displaying hDR18 enhance anti-tumor responses of MSLN-CAR NK cells. Credit:Nature Biotechnology(2024). DOI: 10.1038/s41587-024-02418-6Immunothe

Updated on:October 10,2024

Advanced ovarian cancer drug gets initial 'no' for NHS in England

by Cancer Research UKCC0 Public domainA targeted drug with potential to slow the progress of ovarian cancer has been rejected for use on the NHS in England.In making its provisional decision on r

Updated on: March 06,2024

Advanced ovarian cancer drug gets initial 'no' for NHS in England

by Cancer Research UKCC0 Public domainA targeted drug with potential to slow the progress of ovarian cancer has been rejected for use on the NHS in England.In making its provisional decision on r

Updated on:March 06,2024

Researchers create novel compound targeting melanoma cells

by Boston University School of MedicineMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0An international team of re

Updated on: June 24,2024

Researchers create novel compound targeting melanoma cells

by Boston University School of MedicineMelanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0An international team of re

Updated on:June 24,2024

Researchers unravel novel mechanism by which tumors grow resistant to radiotherapy

by Ludwig Institute for Cancer ResearchRalph Weichselbaum is the co-director of the Ludwig Center at Chicago. Credit: Ludwig Cancer ResearchA Ludwig Cancer Research study has uncovered a key mech

Updated on: March 12,2024

Researchers unravel novel mechanism by which tumors grow resistant to radiotherapy

by Ludwig Institute for Cancer ResearchRalph Weichselbaum is the co-director of the Ludwig Center at Chicago. Credit: Ludwig Cancer ResearchA Ludwig Cancer Research study has uncovered a key mech

Updated on:March 12,2024