Stress granules may drive obesity-associated pancreatic cancer

byThomas Jefferson UniversityCredit: Pixabay/CC0 Public DomainObesity is a known risk factor for at least13 types of cancer, in part because it creates ever-present inflammatory state. For

Updated on: January 16,2024

Stress granules may drive obesity-associated pancreatic cancer

byThomas Jefferson UniversityCredit: Pixabay/CC0 Public DomainObesity is a known risk factor for at least13 types of cancer, in part because it creates ever-present inflammatory state. For

Updated on:January 16,2024

Researchers shed light on signaling pathway responsible for head and neck cancers

by Gina DiGravio,Boston University School of MedicineCausal Inference Models of Interactions Between Pathways/Cell States in Head and Neck Cancer scRNAseq Data. A. Causal inference graphs indica

Updated on: February 18,2024

Researchers shed light on signaling pathway responsible for head and neck cancers

by Gina DiGravio,Boston University School of MedicineCausal Inference Models of Interactions Between Pathways/Cell States in Head and Neck Cancer scRNAseq Data. A. Causal inference graphs indica

Updated on:February 18,2024

Polyploidy study reveals why some cancers are resistant to therapeutic drugs

byOsaka UniversityOverview of the study. (A) We created unique cells with double the usual number of chromosomes to investigate the relationship between polyploidy and DNA damage. (B) After trea

Updated on: November 09,2024

Polyploidy study reveals why some cancers are resistant to therapeutic drugs

byOsaka UniversityOverview of the study. (A) We created unique cells with double the usual number of chromosomes to investigate the relationship between polyploidy and DNA damage. (B) After trea

Updated on:November 09,2024

Poor oral health linked to a 75% increase in liver cancer risk, new study finds

by SAGE PublicationsCredit: CC0 Public DomainThe study, by researchers at Queen's University Belfast, analysed a large cohort of over 469,000 people in the UK, investigated the association be

Updated on: May 21,2024

Poor oral health linked to a 75% increase in liver cancer risk, new study finds

by SAGE PublicationsCredit: CC0 Public DomainThe study, by researchers at Queen's University Belfast, analysed a large cohort of over 469,000 people in the UK, investigated the association be

Updated on:May 21,2024

Lost metabolic fitness of CAR NK cells is key mechanism of tumor resistance, study discovers

byUniversity of Texas M. D. Anderson Cancer CenterCAR-NK cells have a distinct single-cell transcriptome and metabolic profile. Credit:Science Advances(2023). DOI: 10.1126/sciadv.add

Updated on: January 23,2024

Lost metabolic fitness of CAR NK cells is key mechanism of tumor resistance, study discovers

byUniversity of Texas M. D. Anderson Cancer CenterCAR-NK cells have a distinct single-cell transcriptome and metabolic profile. Credit:Science Advances(2023). DOI: 10.1126/sciadv.add

Updated on:January 23,2024

Enzyme inhibition promotes bone formation and curbs the development of bone metastases, study finds

byGerman Cancer Research CenterNegative regulation of bone formation by TAM receptor MERTK.amRNA expression analysis of TAM receptor familyMertk,Tyro3,Axl,Gas

Updated on: January 23,2024

Enzyme inhibition promotes bone formation and curbs the development of bone metastases, study finds

byGerman Cancer Research CenterNegative regulation of bone formation by TAM receptor MERTK.amRNA expression analysis of TAM receptor familyMertk,Tyro3,Axl,Gas

Updated on:January 23,2024

Researchers develop tool that reduces errors in stem cell transplant reporting

by Children's Hospital of PhiladelphiaCredit: CC0 Public DomainResearchers at Children's Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determinatio

Updated on: February 20,2024

Researchers develop tool that reduces errors in stem cell transplant reporting

by Children's Hospital of PhiladelphiaCredit: CC0 Public DomainResearchers at Children's Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determinatio

Updated on:February 20,2024

Specific components of the tumor immune microenvironment may affect responses to BCMA CAR T-cell therapy

byAmerican Association for Cancer ResearchCredit: Unsplash/CC0 Public DomainPatients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer marker

Updated on: January 22,2024

Specific components of the tumor immune microenvironment may affect responses to BCMA CAR T-cell therapy

byAmerican Association for Cancer ResearchCredit: Unsplash/CC0 Public DomainPatients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer marker

Updated on:January 22,2024

Tumor Metabolism Atlas offers a new way to discover cancer mechanisms

byWeill Cornell Medical CollegeCredit: AI-generated imageAn atlas that catalogs gene activity and the levels of small molecules called metabolites in tumor samples offers a new way of identifyin

Updated on: January 22,2024

Tumor Metabolism Atlas offers a new way to discover cancer mechanisms

byWeill Cornell Medical CollegeCredit: AI-generated imageAn atlas that catalogs gene activity and the levels of small molecules called metabolites in tumor samples offers a new way of identifyin

Updated on:January 22,2024

Discovery paves way for precision medicine in future

by University of OtagoThis high-dimensional analysis reveals the T cell signature in people with bowel cancer. The new analysis groups cells together so all cells can be viewed at once. In the pa

Updated on: April 18,2024

Discovery paves way for precision medicine in future

by University of OtagoThis high-dimensional analysis reveals the T cell signature in people with bowel cancer. The new analysis groups cells together so all cells can be viewed at once. In the pa

Updated on:April 18,2024

Therapeutic and diagnostic functions of one antibody for pancreatic cancer

by Osaka UniversityFig.1: DKK1–CKAP4 signaling and application of the anti-CKAP4 antibody. DKK1 and CKAP4 are overexpressed in cancer cells and the PI3 kinase–AKT pathway is activated, promoting

Updated on: May 20,2024

Therapeutic and diagnostic functions of one antibody for pancreatic cancer

by Osaka UniversityFig.1: DKK1–CKAP4 signaling and application of the anti-CKAP4 antibody. DKK1 and CKAP4 are overexpressed in cancer cells and the PI3 kinase–AKT pathway is activated, promoting

Updated on:May 20,2024

Discovery could lead to new drugs to block protein that fuels bowel cancer

by Institute of Cancer ResearchUsing cryo-electron microscopy, researchers obtained a detailed map (shown in orange) of the chain-like tankyrase structure. By interpreting this map and reconstruc

Updated on: February 23,2024

Discovery could lead to new drugs to block protein that fuels bowel cancer

by Institute of Cancer ResearchUsing cryo-electron microscopy, researchers obtained a detailed map (shown in orange) of the chain-like tankyrase structure. By interpreting this map and reconstruc

Updated on:February 23,2024