Researchers design 'prodrug' that targets cancer cells' big appetite for glutamine, leaving healthy cells unharmed

by Johns Hopkins University School of MedicineSchematic showing DRP-104's bio-activation to DON in tumor and bio-inactivation to an inert metabolite in GI tissues. Credit: Jennifer E. Fairman

Updated on: February 18,2024 14

Researchers design 'prodrug' that targets cancer cells' big appetite for glutamine, leaving healthy cells unharmed

by Johns Hopkins University School of MedicineSchematic showing DRP-104's bio-activation to DON in tumor and bio-inactivation to an inert metabolite in GI tissues. Credit: Jennifer E. Fairman

Updated on:February 18,2024 14

Clinical trial generates promising results for immunotherapy drug nivolumab in patients with advanced skin cancer

byWileyCredit: CC0 Public DomainNumerous studies have shown that drugs called immune checkpoint inhibitors can boost the immune system's response against various cancers. Now a phase II clin

Updated on: January 02,2024 9

Clinical trial generates promising results for immunotherapy drug nivolumab in patients with advanced skin cancer

byWileyCredit: CC0 Public DomainNumerous studies have shown that drugs called immune checkpoint inhibitors can boost the immune system's response against various cancers. Now a phase II clin

Updated on:January 02,2024 9

Hypofractioned post-prostatectomy radiotherapy new acceptable practice standard based on NRG Oncology trial findings

by NRG OncologyResults from the Phase III NRG Oncology NRG-GU003 clinical trial comparing hypofractioned post-prostatectomy radiotherapy (HYPORT) to conventionally fractioned post-prostatectomy radiot

Updated on: March 30,2024 0

Hypofractioned post-prostatectomy radiotherapy new acceptable practice standard based on NRG Oncology trial findings

by NRG OncologyResults from the Phase III NRG Oncology NRG-GU003 clinical trial comparing hypofractioned post-prostatectomy radiotherapy (HYPORT) to conventionally fractioned post-prostatectomy radiot

Updated on:March 30,2024 0

Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

by Baylor College of MedicineDr. Xiang 'Shawn' Zhang, the corresponding author of this work. Credit: Baylor College of MedicineIn recent years it has been increasingly appreciated that im

Updated on: April 22,2024 10

Diverse immune cell profiles and roles found in breast cancer resistance to immunotherapy

by Baylor College of MedicineDr. Xiang 'Shawn' Zhang, the corresponding author of this work. Credit: Baylor College of MedicineIn recent years it has been increasingly appreciated that im

Updated on:April 22,2024 10

Study demonstrates antitumor action of substance present in Brazilian green propolis

FEBRUARY 7, 2024byFAPESPLDH assay representing the percentage of membrane integrity damage obtained for fibroblast (A) and glioblastoma (B) cell lines, after 24 h incubation, exposed to 0, 1, 10

Updated on: March 27,2024 4

Study demonstrates antitumor action of substance present in Brazilian green propolis

FEBRUARY 7, 2024byFAPESPLDH assay representing the percentage of membrane integrity damage obtained for fibroblast (A) and glioblastoma (B) cell lines, after 24 h incubation, exposed to 0, 1, 10

Updated on:March 27,2024 4

Research team reveals mechanisms at work in progression of pancreatic cysts to pancreatic cancer

by University of California, San FranciscoPancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstitutePancreatic cysts have gained substantial

Updated on: January 30,2024 10

Research team reveals mechanisms at work in progression of pancreatic cysts to pancreatic cancer

by University of California, San FranciscoPancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstitutePancreatic cysts have gained substantial

Updated on:January 30,2024 10

New study shows recently diagnosed adult cancer survivors at higher risk for bone fractures

byAmerican Cancer SocietyAdult cancer survivors at increased risk for bone fractures. Credit: American Cancer SocietyAdult cancer survivors, particularly those diagnosed within five years and/or

Updated on: January 12,2024 10

New study shows recently diagnosed adult cancer survivors at higher risk for bone fractures

byAmerican Cancer SocietyAdult cancer survivors at increased risk for bone fractures. Credit: American Cancer SocietyAdult cancer survivors, particularly those diagnosed within five years and/or

Updated on:January 12,2024 10

Proximity to muscle cells may promote spread of prostate cancer cells, NIH study suggests

by National Institutes of HealthFrom left to right: prostate cancer cells (square) near skeletal (oblong) and smooth (oval) muscle cells respond to Interleukins 4 and 13 (IL4/13) by producing ann

Updated on: March 08,2024 11

Proximity to muscle cells may promote spread of prostate cancer cells, NIH study suggests

by National Institutes of HealthFrom left to right: prostate cancer cells (square) near skeletal (oblong) and smooth (oval) muscle cells respond to Interleukins 4 and 13 (IL4/13) by producing ann

Updated on:March 08,2024 11

New possibilities for treating intractable brain tumors unveiled

New possibilities for treating intractable brain tumors unveiledbyThe Korea Advanced Institute of Science and Technology (KAIST)Overview of the study on the enhanced response to anti-PD-1 therap

Updated on: December 01,2024 0

New possibilities for treating intractable brain tumors unveiled

New possibilities for treating intractable brain tumors unveiledbyThe Korea Advanced Institute of Science and Technology (KAIST)Overview of the study on the enhanced response to anti-PD-1 therap

Updated on:December 01,2024 0

Experimental drug trial seeks to improve treatment for head and neck cancer

by Cancer Research UKCredit: Cancer Research UKA trial to test an experimental drug in patients with head and neck cancer launches in the UK today (Friday), through the Combinations Alliance – a

Updated on: May 21,2024 4

Experimental drug trial seeks to improve treatment for head and neck cancer

by Cancer Research UKCredit: Cancer Research UKA trial to test an experimental drug in patients with head and neck cancer launches in the UK today (Friday), through the Combinations Alliance – a

Updated on:May 21,2024 4

Skin cancer rewires its energy systems to spread more efficiently, finds study

by Queen Mary, University of LondonDifferent modes of migration and mitochondrial metabolism.a,bOxygen consumption rate (OCR) from cells embedded in a 3D collagen I matrix (n = 

Updated on: February 18,2024 19

Skin cancer rewires its energy systems to spread more efficiently, finds study

by Queen Mary, University of LondonDifferent modes of migration and mitochondrial metabolism.a,bOxygen consumption rate (OCR) from cells embedded in a 3D collagen I matrix (n = 

Updated on:February 18,2024 19

Cancer-seeking molecular delivery system could boost immunotherapy drug, research finds

byUniversity of Rhode IslandCredit: Unsplash/CC0 Public DomainResearchers from the University of Rhode Island and Yale University have demonstrated a promising new approach to delivering immunot

Updated on: January 23,2024 20

Cancer-seeking molecular delivery system could boost immunotherapy drug, research finds

byUniversity of Rhode IslandCredit: Unsplash/CC0 Public DomainResearchers from the University of Rhode Island and Yale University have demonstrated a promising new approach to delivering immunot

Updated on:January 23,2024 20