Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on: February 20,2024

Genetic modifications improve the therapeutic efficacy of iPSC-derived CAR-T cells against solid tumors

by Kyoto UniversityThe CAR construct impacts the differentiation of CAR-iPSCs into T-cell lineages. a, Schematic presentation of the CAR constructs 19z, 1928z, 19bbz, 1928bbz and w/oED28z CAR (w/

Updated on:February 20,2024

Cancer is the biggest health concern among the public, poll reveals

Cancer is the biggest health concern among the public, poll revealsbyUniversity of CambridgeCredit: Pixabay/CC0 Public DomainTwo-thirds of the public say they are very or somewhat worried about

Updated on: July 17,2024

Cancer is the biggest health concern among the public, poll reveals

Cancer is the biggest health concern among the public, poll revealsbyUniversity of CambridgeCredit: Pixabay/CC0 Public DomainTwo-thirds of the public say they are very or somewhat worried about

Updated on:July 17,2024

Pancreatic cancer specialist explains treatment advances and challenges

by Nathan Bahary,The ConversationThe pancreas is located in the abdomen, making diagnosis of pancreatic cancer difficult. Credit:Bruce Blaus/Wikimedia Commons,CC BY-SAWithAlex

Updated on: May 13,2024

Pancreatic cancer specialist explains treatment advances and challenges

by Nathan Bahary,The ConversationThe pancreas is located in the abdomen, making diagnosis of pancreatic cancer difficult. Credit:Bruce Blaus/Wikimedia Commons,CC BY-SAWithAlex

Updated on:May 13,2024

Cancer survivors see mostly positives in how they have changed

by Jeff Grabmeier,The Ohio State UniversityCredit: CC0 Public DomainTwo years after diagnosis, breast cancer survivors have four times more positive than negative thoughts about changes they exp

Updated on: March 12,2024

Cancer survivors see mostly positives in how they have changed

by Jeff Grabmeier,The Ohio State UniversityCredit: CC0 Public DomainTwo years after diagnosis, breast cancer survivors have four times more positive than negative thoughts about changes they exp

Updated on:March 12,2024

Aggressive cancer cells grow by protecting their identity, shows study

byRuhr-Universitaet-BochumGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112533For most types of cancer, the primary tumor is not the cause of death, but m

Updated on: January 22,2024

Aggressive cancer cells grow by protecting their identity, shows study

byRuhr-Universitaet-BochumGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112533For most types of cancer, the primary tumor is not the cause of death, but m

Updated on:January 22,2024

Study highlights difficulty in diagnosing blood disorders, need for coordination between clinicians and pathologists

by University of Miami Leonard M. Miller School of Medicine“Our findings highlight the vital importance of seeking expert opinions from National Cancer Institute-designated cancer centers, especi

Updated on: January 30,2024

Study highlights difficulty in diagnosing blood disorders, need for coordination between clinicians and pathologists

by University of Miami Leonard M. Miller School of Medicine“Our findings highlight the vital importance of seeking expert opinions from National Cancer Institute-designated cancer centers, especi

Updated on:January 30,2024

Collaborative study shows CAR-T cell therapy safe, effective even for high-risk patients

byUniversity of Miami Leonard M. Miller School of MedicineCredit: Pixabay/CC0 Public DomainCAR-T cell therapy is a safe and effective treatment for diffuse large B-cell lymphoma (DLBCL), even fo

Updated on: January 25,2024

Collaborative study shows CAR-T cell therapy safe, effective even for high-risk patients

byUniversity of Miami Leonard M. Miller School of MedicineCredit: Pixabay/CC0 Public DomainCAR-T cell therapy is a safe and effective treatment for diffuse large B-cell lymphoma (DLBCL), even fo

Updated on:January 25,2024

Researchers develop 'Goldilocks drug' to treat triple-negative breast cancer

by Mikayla Mace Kelley,University of ArizonacSNX1.3 competitively inhibits binding of EGFR to SNX1.ARibbon drawing of EGFR kinase domain (PDB ID 5CNO) and SNX1 Bar domain (PDB ID 4FZ

Updated on: February 20,2024

Researchers develop 'Goldilocks drug' to treat triple-negative breast cancer

by Mikayla Mace Kelley,University of ArizonacSNX1.3 competitively inhibits binding of EGFR to SNX1.ARibbon drawing of EGFR kinase domain (PDB ID 5CNO) and SNX1 Bar domain (PDB ID 4FZ

Updated on:February 20,2024

Researchers describe a new resistance mechanism

by IDIBELL-Bellvitge Biomedical Research InstituteDue to the treatment with the antibody against Semaphorin 4D (anti-Sema4D), changes occur in the tumor vasculature as well as a decrease in tumor

Updated on: June 08,2024

Researchers describe a new resistance mechanism

by IDIBELL-Bellvitge Biomedical Research InstituteDue to the treatment with the antibody against Semaphorin 4D (anti-Sema4D), changes occur in the tumor vasculature as well as a decrease in tumor

Updated on:June 08,2024

Circular RNAs—the new frontier in cancer research

byFlinders UniversityCircular RNA biogenesis and how they are dysregulated in cancer. Credit:Nature Reviews Cancer(2024). DOI: 10.1038/s41568-024-00721-7Unraveling the complexities o

Updated on: August 27,2024

Circular RNAs—the new frontier in cancer research

byFlinders UniversityCircular RNA biogenesis and how they are dysregulated in cancer. Credit:Nature Reviews Cancer(2024). DOI: 10.1038/s41568-024-00721-7Unraveling the complexities o

Updated on:August 27,2024

Microbiome provides new clues to determining development of colon cancer

by George Washington UniversityCredit: CC0 Public DomainA mutant protein found in humans with colon cancer blocks a pathway that regulates proliferation and expansion of cells, increasing amounts

Updated on: May 17,2024

Microbiome provides new clues to determining development of colon cancer

by George Washington UniversityCredit: CC0 Public DomainA mutant protein found in humans with colon cancer blocks a pathway that regulates proliferation and expansion of cells, increasing amounts

Updated on:May 17,2024

Researchers propose a navigation system to tackle medication supply bottlenecks

by Christoph Elhardt,ETH ZurichWholesalers can ease supply bottlenecks by rerouting remainder stocks of medications in short supply. Credit: ETH ZurichSupply bottlenecks for medications present

Updated on: May 06,2024

Researchers propose a navigation system to tackle medication supply bottlenecks

by Christoph Elhardt,ETH ZurichWholesalers can ease supply bottlenecks by rerouting remainder stocks of medications in short supply. Credit: ETH ZurichSupply bottlenecks for medications present

Updated on:May 06,2024