Tackling resistance to HIF2 drugs with an RNA-based therapy

byUT Southwestern Medical CenterDownregulation of HIF2α by ARO-HIF2 in patient tumor biopsies. Credit: Dr. Payal KapurExpected to be diagnosed in 2% of men and 1% of women in the U.S., kidney ca

Updated on: December 28,2023

Tackling resistance to HIF2 drugs with an RNA-based therapy

byUT Southwestern Medical CenterDownregulation of HIF2α by ARO-HIF2 in patient tumor biopsies. Credit: Dr. Payal KapurExpected to be diagnosed in 2% of men and 1% of women in the U.S., kidney ca

Updated on:December 28,2023

Possible therapeutic approach to fight incurable blood cancer

by Technical University MunichGraphical abstract. Credit:The EMBO Journal(2022). DOI: 10.15252/embj.2022110871Multiple myeloma (MM) is the second most common type of blood cancer. It

Updated on: January 30,2024

Possible therapeutic approach to fight incurable blood cancer

by Technical University MunichGraphical abstract. Credit:The EMBO Journal(2022). DOI: 10.15252/embj.2022110871Multiple myeloma (MM) is the second most common type of blood cancer. It

Updated on:January 30,2024

Renal impairment linked to worse prognosis in IgD multiple myeloma

by Elana GotkineFor patients with immunoglobulin D multiple myeloma (IgD MM), those with renal impairment (RI) have poorer prognosis and shorter median survival than those with no renal impairment (no

Updated on: January 04,2024

Renal impairment linked to worse prognosis in IgD multiple myeloma

by Elana GotkineFor patients with immunoglobulin D multiple myeloma (IgD MM), those with renal impairment (RI) have poorer prognosis and shorter median survival than those with no renal impairment (no

Updated on:January 04,2024

Study highlights difficulty in diagnosing blood disorders, need for coordination between clinicians and pathologists

by University of Miami Leonard M. Miller School of Medicine“Our findings highlight the vital importance of seeking expert opinions from National Cancer Institute-designated cancer centers, especi

Updated on: January 30,2024

Study highlights difficulty in diagnosing blood disorders, need for coordination between clinicians and pathologists

by University of Miami Leonard M. Miller School of Medicine“Our findings highlight the vital importance of seeking expert opinions from National Cancer Institute-designated cancer centers, especi

Updated on:January 30,2024

Study: Key mechanisms of action differences in immune checkpoint inhibitor combination therapies for advanced melanoma

byH. Lee Moffitt Cancer Center & Research InstituteProposed mechanism of the two ICI combinations. Graphic created with Biorender (biorender.com). ICI, immune checkpoint inhibitor. Credit:&n

Updated on: January 25,2024

Study: Key mechanisms of action differences in immune checkpoint inhibitor combination therapies for advanced melanoma

byH. Lee Moffitt Cancer Center & Research InstituteProposed mechanism of the two ICI combinations. Graphic created with Biorender (biorender.com). ICI, immune checkpoint inhibitor. Credit:&n

Updated on:January 25,2024

Adjuvant therapy for hepatocellular carcinoma after curative treatment: Several unanswered questions

by Xia & He PublishingICI, immune checkpoint inhibitor. Credit: Jian-Hong Zhong, Liang Ma, Le Li, Zhen-Zhen LiHepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and

Updated on: July 17,2024

Adjuvant therapy for hepatocellular carcinoma after curative treatment: Several unanswered questions

by Xia & He PublishingICI, immune checkpoint inhibitor. Credit: Jian-Hong Zhong, Liang Ma, Le Li, Zhen-Zhen LiHepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and

Updated on:July 17,2024

'Magic bullet' takes aim at pancreatic cancer

by University of South AustraliaAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainEvery day, more than 1200 people worldwide are told they

Updated on: March 14,2024

'Magic bullet' takes aim at pancreatic cancer

by University of South AustraliaAxial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domainEvery day, more than 1200 people worldwide are told they

Updated on:March 14,2024

How oxygen deprivation causes cancer cells to spread

byLeiden UniversityCredit: Pixabay/CC0 Public DomainIn breast cancer, metastasis rather than the primary tumor is the cause of death. A lack of oxygen in the tumor cells promotes this metastasis

Updated on: January 02,2024

How oxygen deprivation causes cancer cells to spread

byLeiden UniversityCredit: Pixabay/CC0 Public DomainIn breast cancer, metastasis rather than the primary tumor is the cause of death. A lack of oxygen in the tumor cells promotes this metastasis

Updated on:January 02,2024

Time of day matters when it comes to cancer diagnosis and treatment, says metastasis study

byCell PressCredit: Unsplash/CC0 Public DomainYour circadian rhythm doesn't just govern your sleeping schedule; it can also impact cancer development, diagnosis, and treatment. In a review p

Updated on: January 23,2024

Time of day matters when it comes to cancer diagnosis and treatment, says metastasis study

byCell PressCredit: Unsplash/CC0 Public DomainYour circadian rhythm doesn't just govern your sleeping schedule; it can also impact cancer development, diagnosis, and treatment. In a review p

Updated on:January 23,2024

Right-sided colon cancer patients have poorer survival than those with left-sided disease

by American College of SurgeonsKiller T cells surround a cancer cell. Credit: NIHORLANDO (July 23, 2018): Patients with colorectal cancer tumors on the right side may have poorer five-year surviv

Updated on: May 07,2024

Right-sided colon cancer patients have poorer survival than those with left-sided disease

by American College of SurgeonsKiller T cells surround a cancer cell. Credit: NIHORLANDO (July 23, 2018): Patients with colorectal cancer tumors on the right side may have poorer five-year surviv

Updated on:May 07,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on: April 09,2024

CAR T cell immunotherapy for solid tumors? First, you have to break the cancers' sugar shield

by Delthia Ricks , Medical XpressModeling of the impact of tumor N-glycans on the targeting by CAR T cells. Left, the N-glycan decoration of tumors 1) repels CAR T cells by impeding immunological syna

Updated on:April 09,2024

Cancer metastasis: Tumor plasticity counts

by Université libre de BruxellesCredit: CC0 Public DomainCancer metastasis, which is the propagation of tumor cells into distant organs, is the leading cause of cancer patient mortality. To under

Updated on: March 12,2024

Cancer metastasis: Tumor plasticity counts

by Université libre de BruxellesCredit: CC0 Public DomainCancer metastasis, which is the propagation of tumor cells into distant organs, is the leading cause of cancer patient mortality. To under

Updated on:March 12,2024