Most metastatic colorectal cancers have spread before diagnosis, researchers say

by Stanford University Medical CenterCancer—Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0Up to 80% of metastatic colorectal cancers are likely to have spread to dista

Updated on: June 06,2024

Most metastatic colorectal cancers have spread before diagnosis, researchers say

by Stanford University Medical CenterCancer—Histopathologic image of colonic carcinoid. Credit: Wikipedia/CC BY-SA 3.0Up to 80% of metastatic colorectal cancers are likely to have spread to dista

Updated on:June 06,2024

New promising targeted drug for a rare leukemia

by University of HelsinkiBCL-2 family gene expression in blasts across AML types at single cell resolution. (A) UMAP plot of scRNA-seq data of blasts from AML with megakaryoblastic differentiatio

Updated on: February 18,2024

New promising targeted drug for a rare leukemia

by University of HelsinkiBCL-2 family gene expression in blasts across AML types at single cell resolution. (A) UMAP plot of scRNA-seq data of blasts from AML with megakaryoblastic differentiatio

Updated on:February 18,2024

Researchers discover connection between stress-activated signaling and immune cell evasion in melanoma

by H. Lee Moffitt Cancer Center & Research InstituteGraphical abstract. Credit:Cancer Cell(2022). DOI: 10.1016/j.ccell.2022.08.016Anti-cancer immune cells are critical to inhibiti

Updated on: February 18,2024

Researchers discover connection between stress-activated signaling and immune cell evasion in melanoma

by H. Lee Moffitt Cancer Center & Research InstituteGraphical abstract. Credit:Cancer Cell(2022). DOI: 10.1016/j.ccell.2022.08.016Anti-cancer immune cells are critical to inhibiti

Updated on:February 18,2024

Researchers identify a new biomarker for personalised treatments against cancer

by Institute for Research in Biomedicine (IRB Barcelona)Different localization of the proteins involved in apoptosis in basal (Ctrl) and upon death receptor induction with TRAIL. Credit: Saška Iv

Updated on: June 19,2024

Researchers identify a new biomarker for personalised treatments against cancer

by Institute for Research in Biomedicine (IRB Barcelona)Different localization of the proteins involved in apoptosis in basal (Ctrl) and upon death receptor induction with TRAIL. Credit: Saška Iv

Updated on:June 19,2024

Study validates clinical utility of pan-tumor predictive biomarker for checkpoint inhibitor immunotherapy benefit

by Strata OncologyDevelopment of an integrative immunotherapy response score (IRS) model to stratify PD-(L)1 therapy benefit in patients with advanced solid tumors.aReal-world treatment an

Updated on: February 03,2024

Study validates clinical utility of pan-tumor predictive biomarker for checkpoint inhibitor immunotherapy benefit

by Strata OncologyDevelopment of an integrative immunotherapy response score (IRS) model to stratify PD-(L)1 therapy benefit in patients with advanced solid tumors.aReal-world treatment an

Updated on:February 03,2024

T-cell interactions vary between tumor microenvironments

by Melissa Rohman,Northwestern UniversityShown is a p-STAT3- non-reactive astrocyte (white arrow) in close proximity to a CD3+p-STAT3- T cell (blue arrow) and a CD163+p-STAT3- macrophage (red ar

Updated on: April 01,2024

T-cell interactions vary between tumor microenvironments

by Melissa Rohman,Northwestern UniversityShown is a p-STAT3- non-reactive astrocyte (white arrow) in close proximity to a CD3+p-STAT3- T cell (blue arrow) and a CD163+p-STAT3- macrophage (red ar

Updated on:April 01,2024

Molecule Linking Cancer Driver and Cell Death Genes May Be Effective Against DLBCL

November 2023Thomas R. CollinsMolecules that link cancer driver genes and promoters of cell death genes produce potent killing of diffuse large B-cell lymphoma (DLBCL) cells, according to findings pub

Updated on: February 18,2024

Molecule Linking Cancer Driver and Cell Death Genes May Be Effective Against DLBCL

November 2023Thomas R. CollinsMolecules that link cancer driver genes and promoters of cell death genes produce potent killing of diffuse large B-cell lymphoma (DLBCL) cells, according to findings pub

Updated on:February 18,2024

ACP issues guidance statement for breast cancer screening of average-risk women

by American College of PhysiciansThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by T

Updated on: March 27,2024

ACP issues guidance statement for breast cancer screening of average-risk women

by American College of PhysiciansThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by T

Updated on:March 27,2024

How communication in the tumor microenvironment influences tumor development

by Goethe UniversityTissue section of a lung tumor showing different cells in the tumor microenvironment: macrophages (red), collagen-producing macrophages or fibrocytes (yellow), fibroblasts (green).

Updated on: January 23,2024

How communication in the tumor microenvironment influences tumor development

by Goethe UniversityTissue section of a lung tumor showing different cells in the tumor microenvironment: macrophages (red), collagen-producing macrophages or fibrocytes (yellow), fibroblasts (green).

Updated on:January 23,2024

A potential therapeutic vaccine strategy for a subset of myeloproliferative neoplasms

by Ludwig Cancer ResearchCredit: CC0 Public DomainThe cells of a subset of myeloproliferative neoplasms (MPNs), slow-growing blood cancers, have frameshift mutations in their calreticulin (CALR)

Updated on: January 29,2024

A potential therapeutic vaccine strategy for a subset of myeloproliferative neoplasms

by Ludwig Cancer ResearchCredit: CC0 Public DomainThe cells of a subset of myeloproliferative neoplasms (MPNs), slow-growing blood cancers, have frameshift mutations in their calreticulin (CALR)

Updated on:January 29,2024

Researchers find prostate cancer drug byproduct can fuel cancer cells

by Cleveland ClinicNima Sharifi, MD, Cleveland Clinic Lerner Research Institute. Credit: Cleveland ClinicA genetic anomaly in certain men with prostate cancer may impact their response to common

Updated on: June 15,2024

Researchers find prostate cancer drug byproduct can fuel cancer cells

by Cleveland ClinicNima Sharifi, MD, Cleveland Clinic Lerner Research Institute. Credit: Cleveland ClinicA genetic anomaly in certain men with prostate cancer may impact their response to common

Updated on:June 15,2024

Periostin shows promise to help fight a common form of esophageal cancer

byElsevierSchematic diagram of roles of periostin (POSTN) in the esophageal squamous cell carcinoma (ESCC) microenvironment. Direct contact with ESCC cells leads mesenchymal stem cells (MSCs) to

Updated on: April 28,2024

Periostin shows promise to help fight a common form of esophageal cancer

byElsevierSchematic diagram of roles of periostin (POSTN) in the esophageal squamous cell carcinoma (ESCC) microenvironment. Direct contact with ESCC cells leads mesenchymal stem cells (MSCs) to

Updated on:April 28,2024